Vol 1, No 2 (2011)

LEADING ARTICLE

IS IT NECESSARY TO VACCINATE CHILDREN AGAINST HEPATITIS A ROUTINELY IN PRESENT TIME? THE EVALUATION OF RESULTS OF SUCH STRATEGY OF HEPATITIS A VACCINE PROPHYLAXIS IN SELECTED REGIONS OF THE RUSSIAN FEDERATION

Shakhgildian I.V., Mikhailov M.I., Ershova O.N., Khukhlovitch P.A., Khasanova V.A., Lytkina I.N., Shulakova N.I., Romanenko V.V., Jurovskih A.I., Yasinskiy A.A.

Abstract

Abstract. Data about efficacy of conducting of routine vaccination of children against Hepatitis A are presented in the article. The results of realization such strategy of vaccine prevention of Hepatitis A in selected regions of Russian Federation are evaluated. The perspectives of using this experience in other regions of the country is discussed.

Russian Journal of Infection and Immunity. 2011;1(2):103-106
pages 103-106 views

LECTURES

ETHICAL AND LEGAL ASPECTS OF INFECTOLOGY AND VACCINE PROPHYLAXIS. Part 1. Bioethics and social justice in infectious pathology

Kubar O.I.

Abstract

Abstract. The serial materials on the history of establishment and the modern concepts of bioethics in the field of infectious pathology is planned to present in several articles. In the current report problems of forming and compliance of social responsibility are considered. It is demonstrated the universal importance of ethic principles and specificity of their realization in the different stages of combating with infectious diseases. 

Russian Journal of Infection and Immunity. 2011;1(2):107-112
pages 107-112 views

REVIEW ARTICLES

OPPORTUNITIES OF FLOW CYTOMETRY IN DIAGNOSTICS OF INFECTIOUS DISEASES. Part 2

Khaidukov S.V., Zurochka A.V.

Abstract

Abstract. Flow cytometry allows estimating quantitative and qualitative structure of populations and subpopulations of immune system cells by using various methodical approaches and a wide spectrum of reagents. For diagnostics the Acquired Immune Deficiency Syndrome (AIDS) caused by a Human Immunodeficiency Virus (HIV) the flow cytometry became irreplaceable. Traditionally, immunologists examine standard model of an estimation of immune dysfunction on the basis of classical markers of Т-cells (CD3, CD4, CD8) at the HIV-infection. But researchers pay less attention to other populations and subpopulations of lymphocytes, such as γδ-, αβ- and CD38+ Т-cells. The quantitative estimation of these parameters from a HIV and AIDS patients enables to see pathogenesis a HIV infection and the prediction of its development from another side.

 

Russian Journal of Infection and Immunity. 2011;1(2):113-120
pages 113-120 views

THE MODERN CONCEPTIONS ABOUT IMMUNOPATHOGENESIS OF INFECTION CAUSED BY THE EPSTEIN–BARR VIRUS

Goreiko T.V., Kalinina N.M., Drygina L.V.

Abstract

Abstract. The current review summarizes modern data about structural and functional organization of the Epstein–Barr virus (EBV) and stages of its reproduction. The information concerning immune pathogenesis and clinical features of infection caused by EBV and EBV-associated diseases is presented in the article.

Russian Journal of Infection and Immunity. 2011;1(2):121-130
pages 121-130 views

RUBELLA VIRUS AND ITS TERATOGENIC ACTION. PATHOGENESIS, CLINICAL COURSE, DIAGNOSTICS AND PREVENTION OF CONGENITAL RUBELLA SYNDROME. Part 2. Congenital rubella syndrome

Antipova A.J.

Abstract

Abstract. The second part of the review deals with teratogenic action of the Rubella virus and description of congenital
rubella syndrome (CRS). The review contains updates concerning clinical signs of congenital rubella. The frequency
of CRS in modern period of time is discussed.

Russian Journal of Infection and Immunity. 2011;1(2):131-134
pages 131-134 views

ORIGINAL ARTICLES

EPIDEMIOLOGICAL CHARACTERISTICS OF HEPATITIS A INFECTION IN THE PRE-VACCINATION AND VACCINATION PERIODS

Loshkareva V.N., Semerikov V.V.

Abstract

Abstract. The hepatitis A has important social and economic significance in the Russian Federation now. The analysis of multiyear dynamics of hepatitis A incidence in the regional center — Perm city has been carried out. It was established that vaccination of children against hepatitis A within the different institutions influenced on the intensity of epidemic process. The hepatitis A incidence rates significantly decreased in the vaccinated groups and in the whole population. The typical seasonal distribution of cases and their clustering became less manifested.

Russian Journal of Infection and Immunity. 2011;1(2):135-142
pages 135-142 views

EPIDEMIOLOGICAL CHARACTERISTIC OF VIRAL HEPATITIS B AND C IN THE HEMODIALYSIS UNITS IN SAINT-PETERSBURG IN MODERN TIME. Part 1. Registration of hemo-contact viral hepatitis and serological markers of HBV and HCV infections in patients of hemodialysis unit

Mukomolov S.L., Levakova I.A., Sinaiskaya E.V., Suliagina L.G., Kisliy P.N., Timakhovskaya G.J., Ivanova N.V., Staroselskiy K.G., Ryasnianskiy V.J.

Abstract

Abstract. Hemo-contact viral hepatitis B and C is significant public health problem in hospitals and particularly in hemodialisys units. To define modern situation of the problem the retrospective study of viral hepatitis B and C registration in hemodialysis units in Saint-Petersburg in 1997–2007 as well as testing of 295 patients from four units for serological markers of hepatitis B and C (HBsAg, anti-HBs, anti-HBc, anti-HCV) have been conducted. It was determined that registration of hepatitis B in the study period was 5,2 cases per 1000 patients/per year, hepatitis C — 8,2 cases per 1000 patients/per year. These rates were significantly higher than in the total city population. The serological markers of ongoing or past HBV/HCV infection were revealed in 78,3 per 100 patients. Obtained results confirm intensive viral circulation in hemodialysis units. Additional study of transmission routes using molecular epidemiology techniques is required.

Russian Journal of Infection and Immunity. 2011;1(2):143-150
pages 143-150 views

CLINICAL AND VIROLOGICAL CHARACTERISTICS OF DISEASES ASSOCIATED WITH THE KAPOSI SARCOMA VIRUS

Gurtsevich V.E., Yakovleva L.S., Galetskiy S.A., Afanasieva T.A., Senjuta N.B., Stepina V.N., Kadyrova E.L., Shirokov D.A., Anokhina M.M., Kondratieva T.T., Tupitsin N.N., Zhessan A.

Abstract

Abstract. The paper presents literature data and results of own studies on the Kaposi's sarcoma herpesvirus (KSHV) and its association with Kaposi's sarcoma (KS), the primary effusion lymphoma (PEL) and multicentric Kastleman disease (MCD). The obtained data show that all 3 main clinical forms of KS, diagnosed in Russia, are significantly associated with KSHV, though not always in 100% of cases. Distinct groups of persons with high prevalence of virus infection have been detected among patients with other forms of cancer and non-cancer diseases that may represent a risk factor for development of KS. It was found that the prostate, especially in patients with carcinoma of the prostate and KS could be an important localization of virus and intimate contact with these patients should be limited. For the first time in Russia HIV-negative case of PEL associated with KSHV had been diagnosed and studied in details. It was also demonstrated that isolates of KSHV, circulating in the country, belong to the two major genetic subgroups of the virus (A and C), a widely represented in the European countries and in the United States, which indicates a common origin of the virus in these countries. The current methodologies of KS’ treatment are also presented.

Russian Journal of Infection and Immunity. 2011;1(2):151-160
pages 151-160 views

STUDY OF IMMUNITY TO POLIOVIRUSES ON CERTAIN "SILENT" TERRITORIES OF RUSSIA

Romanenkova N.I., Bichurina M.A., Rozaeva N.R., Shishko L.A.

Abstract

Abstract. The degree of immunity to polioviruses of three serotypes among children of different ages was analysed on certain "controlled" and "silent" territories of Russia in different periods of Polio Eradication Initiative. It was shown that the levels of immunity of children’s population to polioviruses on "controlled" and "silent" territories had no significant difference. It was stated that on the phase which preceded the certification for the absence of circulation of wild polioviruses, when the National Immunisation Days were conducted in the country, the percentage of eronegative children to polioviruses of different serotypes was low on all the territories of Russia. After Russia as a part of the WHO European region was certified as a polio free country and mass immunisation was stopped thepercentage of seronegative children increased, especially to poliovirus of serotype 3, both on the "controlled" and on the "silent" territories.

Russian Journal of Infection and Immunity. 2011;1(2):161-166
pages 161-166 views

ROLE OF POLYMERASE CHAIN REACTION IN THE COMPLEX DIAGNOSTICS OF UROGENITAL INFECTIONS

Gorelova E.V., Boitsov A.G., Domakova T.V., Sheglov V.S.

Abstract

Abstract. The present day there is no universally accepted algorithm for the application of PCR for the diagnostics of urogenital infections and interpretation of results. At the same time, the application of PCR for diagnostics of infection by opportunistic such pathogens as M. hominis, U. parvum can make the antibiotictherapy to be unnecessary.

Russian Journal of Infection and Immunity. 2011;1(2):167-170
pages 167-170 views

SHORT COMMUNICATIONS

THE PERSPECTIVES OF DEVELOPMENT OF NEW PEPTIDE PREPARATIONS FOR CLINICAL USE WHICH HAVE ANTI-INFECTION AND IMMUNE-MODULATING ACTIVITY

Andreeva L.A., Mezentseva M.V., Narovlianskiy A.N., Nagaev I.J., Shapoval I.M., Scherbenko V.E., Russu L.I., Miasoedov N.F.

Abstract

Abstract. The aim of current work is to study influence of peptides in vitro and in vivo on cytokines synthesis (IFNα, IFNγ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-18, TNFα) on the level of their transcription and production. The study of synthesized peptides has shown that all of them had antiviral activity related to tested pathogens (HSV, influenza H3N2, VEMC) with different grade. It could be explained by induction of cytokine response under the action of peptides in norm and in case of viral infections in vitro. However, data obtained in vivo, more adequately characterized antiviral activity of synthesized peptides. The results of study have shown that minimal fragments which had antiviral characteristics are dual peptides Thr-Lys and Gly-Pro; more active as antiviral was peptide Gly-Pro. Thus, our conception about possibility of minimal fragment’s selection from Selank peptide sequence having antiviral activity has been confirmed. This make possible directional construction of new peptides for clinical use which will be helpful in combating with social related diseases as influenza, herpes viral infection etc.

Russian Journal of Infection and Immunity. 2011;1(2):171-176
pages 171-176 views

CHARACTERISTIC OF SENSITIVITY OF STAPHYLOCOCCUS AUREUS AND CANDIDA ALBICANS TO ANTIBACTERIAL PREPARATIONS AND COLLOIDAL SILVER

Afonina I.A., Kraeva L.A., Tseneva G.Y.

Abstract

Abstract. Constant use of antibiotics leads to reliable increasing of resistance among microorganisms. Using non-toxic concentrations of colloidal silver in combination with antimicrobial agents can reduce using concentrations of antibiotics, kept necessary antimicrobial effect. In case of Staphylococcus aureus bactericidal activity of the complex of colloidal silver with unit concentration of neomycin is bigger than the bactericidal effect of double concentration of the antibiotic. Fungicidal effect of combination of antifungal agents with a solution of the colloidal silver on Candida albicans is equal to fungicidal effect of double concentration of antifungal drugs.

Russian Journal of Infection and Immunity. 2011;1(2):177-180
pages 177-180 views

OPPORTUNICTIC ENTEROBACTERIACAE AS THE CAUSE OF THE ACUTE DIARRHEA AND GUT DISBIOSIS

Egorova S.A., Makarova M.A., Kaftyreva L.A.

Abstract

Abstract. Strains of Klebsiella pneumonia isolated from faces were studied to detect virulence factors of “classical” enteric pathogens causing acute diarrhea (Shigella, Salmonella, diarreagenic Escherichia coli). We haven’t detect in Klebsiella the genes encode different virulence factors: the abilities to adherence (sfa, afa, aaf/1, eae), invasion (ipaH, ial), production of heat-lable toxins (elt, LT II), heat-stable toxins (st1, st2) and Shiga toxins (stx1, stx2). Klebsiella spp. is well-known pathogen of the opportunistic infections of urinary tract, blood, wound, respiratory tract. But this bacteria hasn’t virulence factors of diarreagenic Enterobacteriaceae and can’t cause acute diarrhea and other gut pathology.

Russian Journal of Infection and Immunity. 2011;1(2):181-184
pages 181-184 views

SIGNIFICANCE OF UROGENITAL INFECTIONS IN PATHOLOGY OF PREGNANCY AND DELIVERY IN EXPERIMENTS

Arshba I.M., Dzhikidze E.K.

Abstract

Abstract. Development of adequate models in laboratory animals is highly important to detect etiological links between urogenital tract pathology and chlamydia, mycoplasma and ureaplasma bacteria. These model systems can be very useful to find solutions in combating with urogenital tract diseases. One of the obligatory conditions to use monkeys in development of experimental models of infectious and somatic human diseases is knowledge of spontaneous pathology in primates. The present study has shown high frequency of urogenital infections bacteria in the urogenital tract of healthy and sick monkeys.

Russian Journal of Infection and Immunity. 2011;1(2):185-188
pages 185-188 views

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