OPPORTUNITIES OF FLOW CYTOMETRY IN DIAGNOSTICS OF INFECTIOUS DISEASES. Part 2

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  • Authors: Khaidukov S.V.1, Zurochka A.V.2
  • Affiliations:
    1. Институт биоорганической химии им. акад. М.М. Шемякина и Ю.А. Овчинникова РАН, Москва ФГУ Федеральный Научно-Клинический Центр детской гематологии, онкологии и иммунологии РОСЗДРАВА, Москва
    2. Институт иммунологии и физиологии УрО РАН, г. Екатеринбург
  • Issue: Vol 1, No 2 (2011)
  • Pages: 113-120
  • Section: REVIEWS
  • Submitted: 26.06.2014
  • Accepted: 26.06.2014
  • Published: 26.06.2014
  • URL: https://iimmun.ru/iimm/article/view/35
  • DOI: https://doi.org/10.15789/2220-7619-2011-2-113-120
  • ID: 35


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Abstract

Abstract. Flow cytometry allows estimating quantitative and qualitative structure of populations and subpopulations of immune system cells by using various methodical approaches and a wide spectrum of reagents. For diagnostics the Acquired Immune Deficiency Syndrome (AIDS) caused by a Human Immunodeficiency Virus (HIV) the flow cytometry became irreplaceable. Traditionally, immunologists examine standard model of an estimation of immune dysfunction on the basis of classical markers of Т-cells (CD3, CD4, CD8) at the HIV-infection. But researchers pay less attention to other populations and subpopulations of lymphocytes, such as γδ-, αβ- and CD38+ Т-cells. The quantitative estimation of these parameters from a HIV and AIDS patients enables to see pathogenesis a HIV infection and the prediction of its development from another side.

 

About the authors

S. V. Khaidukov

Институт биоорганической химии им. акад. М.М. Шемякина и Ю.А. Овчинникова РАН, Москва

ФГУ Федеральный Научно-Клинический Центр детской гематологии, онкологии и иммунологии РОСЗДРАВА, Москва

Author for correspondence.
Email: khsv@mail.ibch.ru

д.б.н., зав. лабораторией физиологии и патологии иммунной системы

117997, Москва, ул. Миклухо-Маклая, 16/10

Россия

A. V. Zurochka

Институт иммунологии и физиологии УрО РАН, г. Екатеринбург

Email: khsv@mail.ibch.ru
Россия

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