СТРАТЕГИИ ПРОГРАММИРОВАННОЙ КЛЕТОЧНОЙ ГИБЕЛИ У ПРОКАРИОТ

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Аннотация

Программированная гибель клеток (ПГК) была впервые изучена в эукариотических организмах. Эта система также функционирует в процессе развития прокариот. Система ПГК у микроорганизмов активируется широким спектром сигналов в ответ на стрессы, связанные с неблагоприятными условиями окружающей среды или воздействием антибактериальных средств. Результаты многочисленных исследований, проведенных в последнее десятилетие, позволяют рассматривать систему ПГК у прокариот как средство эволюционного сохранения вида. Эти результаты существенно расширили представления о роли ПГК у микроорганизмов и открыли ряд важных направлений исследований, морфологических и молекулярно-генетических подходов к изучению стратегий смерти ради выживания у бактериальных популяций. Цель обзора: обобщение сведений о морфологических и молекулярно-генетических признаках ПГК у прокариот, являющихся реальными проявлениями механизмов этого феномена. 

Об авторах

Б. Г. Андрюков

690087, Россия, г. Владивосток, ул. Сельская, 1, ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН.

Автор, ответственный за переписку.
Email: andrukov_bg@mail.ru

д.м.н., ведущий научный сотрудник лаборатории молекулярной эпидемиологии и микробиологии ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН, г. Владивосток, Россия;

Россия

Л. М. Сомова

690087, Россия, г. Владивосток, ул. Сельская, 1, ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН.

Email: fake@neicon.ru

д.м.н., профессор, директор ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН, г. Владивосток, Россия; 

Россия

Н. Ф. Тимченко

690087, Россия, г. Владивосток, ул. Сельская, 1, ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН.

Email: fake@neicon.ru

д.м.н., профессор, ведущий научный сотрудник лаборатории молекулярной эпидемиологии
и микробиологии ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН, г. Владивосток, Россия. 

Россия

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