Russian Journal of Infection and ImmunityRussian Journal of Infection and ImmunityИнфекция и иммунитет2220-76192313-7398SPb RAACI26910.15789/2220-7619-2015-1-15-26REVIEWSОБЗОРЫSTRATEGY OF PROGRAMMED CELL DEATH IN PROKARYOTESСТРАТЕГИИ ПРОГРАММИРОВАННОЙ КЛЕТОЧНОЙ ГИБЕЛИ У ПРОКАРИОТAndrukovB. G.АндрюковБ. Г.
Russian Federation

PhD, MD (Medicine), Leading Researcher, Laboratory of Molecular Epidemiology and Microbiology, Somov Research Institute of Epidemiology and Microbiology, Siberian Branch of RAMS, Vladivostok, Russian Federation;

д.м.н., ведущий научный сотрудник лаборатории молекулярной эпидемиологии и микробиологии ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН, г. Владивосток, Россия;

andrukov_bg@mail.ruSomovaL. M.СомоваЛ. М.
Russian Federation

PhD, MD (Medicine), Professor, Director of Somov Research Institute of Epidemiology and Microbiology, Siberian Branch of RAMS, Vladivostok, Russian Federation;

д.м.н., профессор, директор ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН, г. Владивосток, Россия; 

TimchenkoN. F.ТимченкоН. Ф.
Russian Federation

PhD, MD (Medicine), Professor, Leading Researcher, Laboratory of Molecular Epidemiology and Microbiology, Somov Research Institute of Epidemiology and Microbiology, Siberian Branch of RAMS, Vladivostok, Russian Federation.

д.м.н., профессор, ведущий научный сотрудник лаборатории молекулярной эпидемиологии и микробиологии ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН, г. Владивосток, Россия. 

690087, Russian Federation, Vladivostok, Selskaya str., 1, Somov Research Institute of Epidemiology and Microbiology, Siberian Branch of RAMS.690087, Россия, г. Владивосток, ул. Сельская, 1, ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН.210420155115262104201521042015Copyright ©; 2015, Andrukov B.G., Somova L.M., Timchenko N.F.Copyright ©; 2015, Андрюков Б.Г., Сомова Л.М., Тимченко Н.Ф.2015Andrukov B.G., Somova L.M., Timchenko N.F.Андрюков Б.Г., Сомова Л.М., Тимченко Н.Ф.https://creativecommons.org/licenses/by/4.0https://iimmun.ru/iimm/article/view/269

Programmed cell death (PCD) was first studied in eukaryotic organisms. This system also operates in the development life cycle of prokaryotes. The system PCD in microorganisms is activated a wide range of signals in response to the stresses associated with adverse environmental conditions or exposure to antibacterial agents. The results of numerous studies in the past decade allow considering the system PCD in prokaryotes as an evolutionary conservation of the species. These results significantly expanded understanding of the role of PCD in microorganisms and opened a number of important areas of research of the morphological and molecular genetic approaches to the study of death strategies for the survival in bacterial populations. The purpose of the review is to summarize the morphological and molecular genetic characteristics of PCD in prokaryotes which are real manifestations of the mechanisms of this phenomenon. 

Программированная гибель клеток (ПГК) была впервые изучена в эукариотических организмах. Эта система также функционирует в процессе развития прокариот. Система ПГК у микроорганизмов активируется широким спектром сигналов в ответ на стрессы, связанные с неблагоприятными условиями окружающей среды или воздействием антибактериальных средств. Результаты многочисленных исследований, проведенных в последнее десятилетие, позволяют рассматривать систему ПГК у прокариот как средство эволюционного сохранения вида. Эти результаты существенно расширили представления о роли ПГК у микроорганизмов и открыли ряд важных направлений исследований, морфологических и молекулярно-генетических подходов к изучению стратегий смерти ради выживания у бактериальных популяций. Цель обзора: обобщение сведений о морфологических и молекулярно-генетических признаках ПГК у прокариот, являющихся реальными проявлениями механизмов этого феномена. 

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