LISTERIA MONOCYTOGENES: SPREADING AND MECHANISMS OF IMMUNE RESPONSE

Cover Page

Cite item

Abstract

Abstract. Gram-positive bacteria Listeria monocytogenes (LM) the causative agent of listeriosis is one of the pathogens entering to the human organism by food products. The listeriosis is one of the oldest experimental infection and LM is the classic object for study of cell immunity mechanisms. It was established that virulent bacteria L. monocytogenes induce infected immune cells to avoid own protective response. The authors conducted experiments to study changes in immune response indicators in mice in the different stages of infection (during 3–5 days) caused by L. monocytogenes EGDe (wt) strain and bacteria of isogeneic strains with mutations in genes controlled production of PAMPs (d28, i28). Analysis of published data and obtained results of this study allows to make a conclusion that immune response in listeriosis plays an important role and it depends on pathogen strain, bacteria doses and another condition of infection. Conducted study can be useful in case of choosing of treatment tactic of disease caused by Listeria monocytogenes, and, probable another diseases, caused by intracellular bacteria.

About the authors

I. F. Antoshina

ФГБУ НИИЭМ имени Н.Ф. Гамалеи Минздравсоцразвития России, Москва

Email: marmez@mail.ru
Russian Federation

M. V. Mezentseva

ФГБУ НИИ вирусологии имени Д.И. Ивановского Минздравсоцразвития России, Москва

Author for correspondence.
Email: marmez@mail.ru

д.б.н., старший научный сотрудник лаборатории культур тканей

123098, Москва, ул. Гамалеи, 16

Russian Federation

References

  1. Воробьев А.А., Середа А.Д., Бакулов И.А., Котляров В.М. Иммунитет при листериозе // ЖМЭИ. — 2000. — № 5. — С. 98–102.
  2. Зайцева Е.А., Ермолаева С.А., Сомов Г.П. Гены, кодирующие факторы инвазии у штаммов Listeria monocytogenes, изолированных в Европейской части и Дальневосточном регионе России // ЖМЭИ. — 2006. — № 4. — С. 42–45.
  3. Тартаковский И.С., Малеев В.В., Ермолаева С.А. Листерии: роль в инфекционной патологии человека и лабораторная диагностика. — М.: Медицина для всех, 2002. — 200 с.
  4. Beutler B., Tkagenko V., Milsark I., Krochin M., Cerami A. Effect of y interferon on cachectin expression by mononuclear phagocytes, reversal of the lpsd (endotoxin resistance) phenotype // J. Exp. Med. — 1986. — Vol. 164. — Р. 1791–1796.
  5. Brinkmann V., Reichard U., Goosmann C., Fauler B., Uhlemann Y., Weiss D.S., Weinrauch Y., Zychlinsky A. Neutrophil extracellular traps kill bacteria // Science. — 2004. — Vol. 303. — P. 1532–1535.
  6. Brzoza K.L., Rockel A.B., Hiltbold E.M. Cytoplasmic entry of Listeria monocytogenes enhances dendritic cell maturation and T cell differentiation and function // J. Immunol. — 2004. — Vol. 173. — P. 2641–2651.
  7. Carrero J.A., Calderon B., Unanue E.R. Lymphocytes are detrimental during the early innate immune response against Listeria monocytogenes // J. Exp. Med. — 2006. — Vol. 203. — P. 933–940.
  8. Conlan J.W. Early pathogenesis of Listeria monocytogenes infection in the mouse spleen // J. Med. Microbiol. — 1996. — Vol. 44. — P. 295–302.
  9. Czuprynski C.J., Brown J.F., Wagner R.D., Steinberg H. Administration of antigranulocyte monoclonal antibody RB6-8C5 prevents expression of acquired resistance to Listeria monocytogenes infection in previously immunized mice // Infect. Immun. — 1994. — Vol. 62. — P. 5161–5163.
  10. Daugelat S., Ladel C.H., Schoel B., Kaufmann S.H. Antigen-specific Tcell responses during primary and secondary Listeria monocytogenes infection // Infect. Immun. — 1994. — Vol. 62. — P. 1881–1888.
  11. Edelson B.T., Unanue E.R. Intracellular antibody neutralizes Listeria growth // Immunity. — 2001. — Vol. 14. — P. 503–512.
  12. Guleria I., Pollard J.W. Aberrant macrophage and neutrophil population dynamics and impaired Th1 response to Listeria monocytogenes in colony-stimulating factor 1-deficient mice // Infect. Immun. — 2001. — Vol. 69. — P. 1795–1807.
  13. Harty J.T., Bevan M.J. Specific immunity to Listeria monocytogenes in the absence of IFN gamma // Immunity. — 1995. — Vol. 3. — P. 109–117.
  14. Havel E.A., Moldawer L.L., Helfgott D., Kilian P.L., Shegal P.B. Type-1 IL-1 receptor blockade exacerbates murine listeriosis // J. Immunol. — 1992. — Vol. 148. — P. 1486 –1490.
  15. Hiromatsu K., Yoshikai Y., Matsuzaki G., Ohga S., Muramori K., Matsumoto K., Bluestone J.A., Nomoto K. A protective role of gamma/delta T cells in primary infection with Listeria monocytogenes in mice // J. Exp. Med. — 1992. — Vol. 175. — P. 49–56.
  16. Igarashi K.I., Mitsuyama M., Muramori K., Tsukada H., Nomoto K. Interleukin-1-induced promotion of T-cell differentiation in mice immunized with killed Listeria monocytogenes // Infect. Immun. — 1990. — Vol. 58. — P. 3973–3979.
  17. Jung S., Unutmaz D., Wong P., Sano G., De los Santos K., Sparwasser T., Wu S., Vuthoori S., Ko K., Zavala F., Pamer E.G., Littman D.R., Lang R.A. In vivo depletion of CD11 dendritic cells abrogates priming of CD8 T cells by exogenous cell-associated antigens // Immunity. — 2002. — Vol. 17. — P. 211–220.
  18. Koerner T.J., Adams D.O., Hamilton T.A. Regulation of tumor necrosis factor (TNF) expression: interferon-γ enhances the accumulation of inRNA for TNF induced by lipopolysaccharide in murine peritoneal macrophages // Cell. Immunol. — 1987. — Vol. 109. — P. 437–443.
  19. Kuhn M., Goebel W. Induction of cytokines in phagocytic mammalian cells infected with virulent and avirulent Listena strains // Infect. Immun. — 1994. — Vol. 62. — P. 348–356.
  20. Kurtz R.S., Young K.M., Czuprynski C.J. Separate and combined effects of recombinant interleukin-lot and gamma interferon on antibacterial resistance // Infect. Immun. — 1989. — Vol. 57. — P. 553–558.
  21. Mackaness G.B. Cellular resistance to infection // J. Exp. Med. — 1962. — Vol. 116. — P. 381–406.
  22. Mandel T.E., Cheers C. Resistance and susceptibility of mice to bacterial infection: histopathology of listeriosis in resistant and susceptible strains // Infect. Immun. — 1980. — Vol. 30. — P. 851–861.
  23. McCaffrey R.L., Fawcett P., O’Riordan M., Lee K.D., Havell E.A., Brown P.O., Portnoy D.A. A specific gene expression program triggered by Gram-positive bacteria in the cytosol // Proc. Natl. Acad. Sci. USA. — 2004. — Vol. 101. — P. 11386–11391.
  24. Medzhitov R. Toll-like receptors and innate immunity // Nat. Rev. Immunol. — 2001. — Vol. 1. — P. 135–145.
  25. Mitsuyama M., Igarashi K., Kawamura I., Ohmori T., Nomoto K. Difference in the induction of macrophage interleukin-1 production between viable and killed cells of Listeria monocytogenes // Infect. Immun. — 1990. — Vol. 58. — P. 1254–1260.
  26. Nakane A., Numata A., Minagawa T. Endogenous tumor necrosis factor, interleukin-6, and gamma interferon levels during Listeria monocytogenes infection in mice // Infect. Immun. — 1992. — Vol. 60. — P. 523–528.
  27. Ochsenbein A.F., Fehr T., Lutz C., Suter M., Brombacher F., Hengartner H., Zinkernagel R.M. Control of early viral and bacterial distribution and disease by natural antibodies // Science. — 1999. — Vol. 286. — P. 2156 –2159.
  28. O’Riordan M., Yi C.H., Gonzales R., Lee K.D., Portnoy D.A. Innate recognition of bacteria by a macrophage cytosolic surveillance pathway // Proc. Natl. Acad. Sci. USA. — 2002. — Vol. 99. — P. 13861–13866.
  29. Pizarro-Cerda J., Cossart P. Bacterial adhesion and entry into host cells // Cell. — 2006. — Vol. 124. — P. 715 –727.
  30. Pizarro-Cerda J., Payrastre B. Wang Y.J., Veiga E., Yin H.L., Cossart P. Type II phosphatidylinositol 4-kinases promote Listeria monocytogenes entry into target cells // Cell. Microbiol. — 2007. — Vol. 9. — P. 2381–2390.
  31. Queiroz M.L., Bincoletto C., Valadares M.C., Dantas D.C., Santos L.M. Effects of Chlorella vulgaris extract on cytokines production in Listeria monocytogenes infection // Immunopharmacol. Immunotoxicol. — 2002. — Vol. 24. — P. 483–496.
  32. Rayamajhi M., Humann J., Penheiter K., Andreasen K., Lenz L.L. Induction of IFNαβ enables Listeria monocytogenes to suppress macrophage activation by IFNγ // J. Exp. Med. Vol. — Vol. 207, N 2. — P. 327–337.
  33. Rogers H.W., Unanue E.R. Neutrophils are involved in acute, nonspecific resistance to Listeria monocytogenes in mice // Infect. Immun. — 1993. — Vol. 61. — P. 5090–5096.
  34. Roll J.T., Young K.M., Kurtz R.S., Czuprynski C.J. Human rTNFcx augments anti-bacterial resistance in mice: potentiation of its effects by recombinant human IL-1lo // Immunology. — 1990. — Vol. 69. — P. 316 –322.
  35. Segal A.W. How neutrophils kill microbes // Annu. Rev. Immunol. — 2005. — Vol. 23. — P. 197–223.
  36. Serbina N.V., Kuziel W., Flavell R., Akira S., Rollins B., Pamer E.G. Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection // Immunity. — 2003. — Vol. 19, N 6. — P. 891–901.
  37. Shen H., Whitmire J.K., Fan X., Shedlock D.J., Kaech S.M., Ahmed R. A specific role for B cells in the generation of CD8 T cell memory by recombinant Listeria monocytogenes // J. Immunol. — 2003. — Vol. 170. — P. 1443–1451.
  38. Stoiber D., Stockinger S., Steinlein P., Kovarik J., Decker T. Listeria monocytogenes Modulates Macrophage Cytokine Responses Through STAT Serine Phosphorylation and the Induction of Suppressor of Cytokine Signaling // J. Immunology. — 2001. — Vol. 166, N 1. — P. 466–472.
  39. Tham T.N., Gouin E., Rubinstein E., Boucheix C., Cossart P., Pizarro-Cerda J. Tetraspanin CD81 is required for Listeria monocytogenes invasion // Infect. Immun. — 2010. — Vol. 78, N 1. — P. 204–209.
  40. Tripp C.S., Wolf S.F., Unanue E.R. Interleukin 12 and tumor necrosis factor alpha are costimulators of interferon gamma production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist // Proc. Natl. Acad. Sci. USA. — 1993. — Vol. 90. — P. 3725–3729.
  41. Xiong H., Kawaura I., Nishibori T., Matsuyama M. Cytokine gene expression in mice at an early stage of infection with various strains of Listeria spp. differing in virulence // Infect. Immun. — 1994. — Vol. 62, N 9. — P. 3649–3654.
  42. Zenewicz L.A., Shen H. Innate and adaptive immune responses to Listeria monocytogenes: a short overview // Microbes Infect. — 2007. — Vol. 9. — P. 1208–1215.

Copyright (c) 2014 Antoshina I.F., Mezentseva M.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 64788 от 02.02.2016.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies