MOLECULAR-GENETIC BASIS OF PHYSIOLOGY AND PATHOGENICITY OF COXIELLA BURNETII

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Abstract. The agent of Q-fever Coxiella burnetii is unusual intracellular pathogen which is possessed of biggest transporting and metabolic abilities in compare with microorganisms with similar parasitic strategy. It is supposed that different strains of the pathogen exist in various stages of pathological adaption and have different potential of virulence. The structure of C. burnetii genome, characteristics of metabolic routes, mechanisms of interaction with host cells and possible virulence factors are discussed in the review. The special attention is paid to Coxiella genotyping methods and possible correlations between genomic polymorphism of different strains and their virulence potential.

About the authors

Yu. A. Panpherova

ФБУН НИИ эпидемиологии и микробиологии имени Пастера, Санкт-Петербург

Author for correspondence.
Email: zoonoses@mail.ru

научный сотрудник лаборатории зооантропонозов

197101, Санкт-Петербург, ул. Мира, 14

Russian Federation

References

  1. Beare P., Samuel J., Howe D., Virtaneva K., Porcella S., Heinzen R. Genetic diversity of the Q fever agent, Coxiella burnetii, assessed by microarray-based whole-genome comparisons // J. Bacteriol. — 2006. — Vol. 188. — P. 2309–2324.
  2. Beare P., Unsworth N., Andoh M., Voth D., Omsland A., Gilk S., Williams K., Sobral B., Kupko J., Porcella S., Samuel J., Heinzen R. Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella // J. Infect. Immun. — 2009. — Vol. 77. — P. 642–656.
  3. Chen C., Banga S., Mertens K., Weber M., Gorbaslieva I., Tan Y., Luo Z., Samuel J. Large-scale identificationand translocation of type IV secretion substrates by Coxiella burnetii // Proc. Natl. Acad. Sci. USA. — 2010. — Vol. 107, N 50. — P. 21755–21760.
  4. Cirillo S., Lum J., Cirillo J. Identification of novel loci involved in entry by Legionella pneumophila // Microbiology. — 2000. — Vol. 146. — P. 1345–1359.
  5. Coleman S., Fischer E., Cockrell D., Voth D., Howe D., Mead D., Samuel J., Heinzen R. Proteome and antigen profiling of Coxiella burnetii developmental forms // J. Infect. Immun. — 2007. — Vol. 75. — P. 290–298.
  6. Colombo M., Gutierrez M., Romano P. The two face of autophagy: Coxiella and Mycobacterium // Autophagy. — 2006. — Vol. 2, N 3. — P. 162–164.
  7. Denison A., Thompson H., Massung R. IS1111insertion sequences of Coxiella burnetii: characterization and use for repetitive element PCR-based differentiation of Coxiella burnetii isolates // BMC Microbiol. — 2007. — Vol. 7. — P. 91.
  8. Domingues P., Palkovic P., Toman R. Analysis of phospholipids from Coxiella burnetii by fast atom bombardment mass spectrometry. A rapid method for differentiation of virulent phase I and low virulent phase II cells // Acta Virol. — 2002. — Vol. 46. — P. 121–124.
  9. Fehlner-Gardiner C., Roshick C., Carlson J., Hughes S., Belland R., Caldwell H., McClarty G. Molecular basis defining human Chlamydia trachomatis tissue tropism: a possible role for tryptophan synthase // J. Biol. Chem. — 2002. — Vol. 277, N 30. — P. 893–903.
  10. Feldman N., Zusman T., Hagag S., Segal G. Coevolution between nonhomologous but functionally similar proteins and their conservative patterns in the Legionella pathogenesis system // Proc. Natl. Acad. Sci USA. — 2005. — Vol. 102, N 34. — P. 12206–12211.
  11. Hacker J., Blum-Oehler G., Hochhut B., Dobrindt U. The molecular basis of infectious diseases: pathogenicity islands and other mobile genetic elements // Acta Microbiol. Immunol. Hung. — 2003. — Vol. 50. — P. 321–330.
  12. Hackstadt T., Williams J. Biochemical stratagem for obligate parasitism of eukaryotic cells by Coxiella burnetii // Proc. Natl. Acad. Sci USA. — 1981. — Vol. 78. — P. 3240–3244.
  13. Hackstadt T., Peacock M., Hitchcock P., Cole R. Lipopolysaccharide variation in Coxiella burnetti: intrastrain heterogeneity in structure and antigenicity // J. Infect. Immun. — 1985. — Vol. 48. — P. 359–365.
  14. Hackstadt T. The role of lipopolysaccharides in the virulence of Coxiella burnetii // Ann. N.Y. Acad. Sci. — 1990. — Vol. 590. — P. 27–32.
  15. Heinzen R., Hackstadt T. A developmental stage-specific histone H1 homolog of Coxiella burnetii // J. Bacteriol. — 1996. — Vol. 178. — P. 5049–5052.
  16. Heinzen R., Howe D., Mallavia L., Rockey D., Hacks tadt T. Developmentally regulated synthesis of an unusually small, basic peptide by Coxiella burnetii // J. Mol. Microbiol. — 1996. — Vol. 22. — P. 9 –19.
  17. Hendrix L., Samuel J., Mallavia L. Differentiation of Coxiella burnetii isolates by analysis of restriction-endonuclease-digested DNA separated by SDS-PAGE // J. Gen. Microbiol. — 1991. — Vol. 137. — P. 269 –276.
  18. Hoover T., Vodkin M., Williams J. A Coxiella burnetii repeated DNA element resembling a bacterial insertion sequence // J. Bacteriol. — 1992. — Vol. 174. — P. 5540–5548.
  19. Hoover T., Culp D., Vodkin M., Williams J., Thompson H. Chromosomal DNA deletions explain phenotypic characteristics of two antigenic variants, phase II and RSA 514 (Crazy), of the Coxiella burnetii Nine Mile strain // Infect Immun. — 2002. — Vol. 70. — P. 6726 – 6733.
  20. Juhas M., Crook D., Hood D. Type IV secretion systems: tools of bacterial horizontal gene transfer and virulence // J. Cell Microbiol. — 2008. — Vol. 10. — P. 2377–2386.
  21. Lautenschläger S., Willems H., Jäger C., Baljer G. Sequencing of the cryptic plasmid QpRS from Coxiella burnetii // Plasmid. — 2000. — Vol. 44. — P. 85–88.
  22. Lin Z., Mallavia L. Identification of partition region carried by the plasmid QpH1 of Coxiella burnetii // J. Molec. Microbiol. — 1994. — Vol. 13. — Р. 515–523.
  23. Lin Z., Mallavia L. The partition region of plasmid QpH1 is a member of a family of two trans-acting factors as implied by sequence analysis // J. Gene. — 1995. — Vol. 160. — P. 69–74.
  24. Lin Z., Mallavia L. Functional analysis of the active partition region of the Coxiella burnetii plasmid QpH1 // J. Bacteriol. — 1999. — Vol. 181, N 6. — P. 1947–1952.
  25. Mallavia J., Frazier M., Mallavia L. Stability of plasmid sequences in an acute Q-fever strain of Coxiella burnetii // J. Gen. Microbiol. — 1 988. — Vol. 134. — P. 1795–1805.
  26. Mallavia, L., Samuel J., Frazier M. The genetics of Coxiella burnetii: etiologic agent of Q fever and chronic endocarditis // Q fever: The biology of Coxiella burnetii. — Eds. J.C. Williams, H.A. Thompson. — Boca Raton, FL, 1991. — P. 259–284.
  27. Marrie T. Q fever — a review // Can. Vet. J. — 1990. — Vol. 31, N 8. — P. 555–563.
  28. Maurin M., Raoult D. Q fever // Clin. Microbiol. Rev. — 1999. — Vol. 12, N 4. — P. 518–553.
  29. McCaul T., Williams J. Developmental cycle of Coxiella burnetii: structure and morphogenesis of vegetative and sporogenic differentiations // J. Bacteriol. — 1981. — Vol. 147. — P. 1063–1076.
  30. Mege J., Maurin M., Capo C., Raoult D. Coxiella burnetii: the ‘query’ fever bacterium. A model of immune subversion by a strictly intracellular microorganism // FEMS Microbiol Rev. — 1997. — Vol. 19, N 4. — P. 209 –217.
  31. Minnick M., Heinzen R., Frazier M., Mallavia L. Characterization and expression of the cbbE’ gene of Coxiella burnetii // J. Gen. Microbiol. — 1990. — Vol. 136, N 6. — P. 1099–1107.
  32. Omsland A., Cockrell D., Fischer E., Heinzen R. Sustained axenic metabolic activity by the obligate intra-cellular bacterium Coxiella burnetii // J. Bacteriol. — 2008. — Vol. 190, N 9. — P. 3203–3212.
  33. Park, J., Kim K., Choi K., Grab D., Dumler J. Anaplasma phagocytophilum AnkA binds to granulocyte DNA and nuclear proteins // J. Cell. Microbiol. — 2005. — Vol. 6. — P. 743–751.
  34. Pietrokovski S. Molecular organization of inteins and C-terminal autocatalytic domain // Protein Sci. — 1988. — Vol. 7. — P. 64–71.
  35. Raghavan R, Miller L, Hicks L., Minnick M. The unusual 23S rRNA gene of Coxiella burnetii: two self-splicing group I introns flank a 34-base-pair exon, and one element lacks the canonical omegaG // J. Bacteriol. — 2007. — Vol. 189, N 18. — P. 6572–6579.
  36. Raghavan R., Hicks L, Minnick M. Toxic introns and parasitic intein in Coxiella burnetii: legacies of promiscuous past // J. Bacteriol. — 2008. — Vol. 190, N 17. — P. 5934–5943.
  37. Roman M., Crissman H., Samsonoff W., Hechemy K., Baca O. Analysis of Coxiella burnetii isolates in cell culture and the expression of parasite-specific antigens on the host membrane surface // Acta Virol. — 1991. — Vol. 35, N 6. — P. 503–510.
  38. Russell-Lodrigue K., Andoh M., Poels M., Shive H., Weeks B., Zhang G., Tersteeq C., Maseqi T., Hotta A., Yamaguchi T., Fukushi H., Hirai K., McMurray D., Samuel J. Coxiella burnetii isolates cause genogroup-specific virulence in mouse and guinea pig models of acute Q fever // J. Infect. Immun. — 2009. — Vol. 77, N 12. — P. 5640–5650.
  39. Samoilis G., Aivaliotis M., Vranakis I., Papadioti A., Tselentis Y., Tsylotis G., Psaroulaki A. Proteomic screening for possible effector molecules secreted by the obligate intracellular pathogen Coxiella burnetii // J. Proteome Res. — 2010. — Vol. 5. — P. 1619–1626.
  40. Samuel J., Frazier E., Mallavia L. Correlation of plasmid type and disease caused by Coxiella burnetii // J. Infect. Immun. — 1985. — Vol. 49. — P. 775–779.
  41. Samuel J., Frazier E., Mallavia L. Stability of plasmid sequences in an acute Q-fever strain of Coxiella burnetii // J. Gen. Microbiol. — 1988. — Vol. 134, N 7. — P. 1795–1805.
  42. Samuel J., Kiss K., Varghees S. Molecular pathogenesis of Coxiella burnetii in a genomics era // Ann. N.Y. Acad. Sci. — 2003. — Vol. 990. — P. 653–663.
  43. Segal G., Feldman M., Zusman T. The Icm/Dot type IV secretion system of Legionella pneumophila and Coxiella burnatii // FEMS Microbiol. Rev. — 2005. — Vol. 29. — P. 65–81.
  44. Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., Deboy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A., Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Complete genome sequence of the Q-fever pathogen Coxiella burnetii // Proc. Nat. Acad. Sci. USA. — 2003. — Vol. 100, N 9. — P. 5455–5460.
  45. Sexton J., Vogel J. Type IVB secretion by intracellular pathogens // Traffic. — 2002. — Vol. 3. — P. 178–185.
  46. Spyridaki I., Psaroulaki A., Aransay A., Scoulica E., Tselentis Y. Diagnosis of quinolone-resistant Coxiella burnetii strains by PCR-RFLP // J. Clin. Lab. Anal. — 2000. — Vol. 14. — P. 59–63.
  47. Stein A., Saunders N., Taylor A., Raoult D. Phylogenic homogeneity of Coxiella burnetii strains as determinated by 16S ribosomal RNA sequencing // FEMS Microbiol Lett. — 1993. — Vol. 113. — P. 339–344.
  48. Stein A., Kruszewska D., Gouvernet J., Raoult D. Study of the 16S-23S ribosomal DNA internal spacer of Coxiella burnetii // Eur. J. Epidemiol. — 1997. — Vol. 13. — P. 471–475.
  49. Stone B., Kwaik Y. Natural competence for DNA transformation by Legionella pneumophila and its association with expression of type IV pili // J. Bacteriol. — 1999. — Vol. 181. — P. 1395–1402.
  50. Suhan M., Chen S., Thompson H. Transformation of Coxiella burnetii to ampicillin resistance // J. Bacteriol. — 1996. — Vol. 178. — P. 2701–2708.
  51. Svraka S., Toman R., Skultety L., Slaba K., Homan W. Establishment of a genotyping scheme for Coxiella burnetii // FEMS Microbiol. Lett. — 2006. — Vol. 254. — P. 268–274.
  52. Vodkin M., Williams J. A heat shock operon in Coxiella burnetii produces a major antigen homologous to a protein in both mycobacteria and Esherichia coli // J. Bacteriol. — 1988. — Vol. 170. — P. 1227–1234.
  53. Voth D.E., Beare P.A., Howe D., Sharma U.M., Samoilis G., Cockrell D.C., Omsland A., Heinzen R.A. The Coxiella burnetii cryptic plasmid is enriched in genes encoding type IV secretion systems substrate // J. Bacteriol. — 2011. — Vol. 193, N 7. — P. 1493-1503.
  54. Weisburg W.G., Dobson M.E., Samuel J.E., Dasch G.A., Mallavia L.P., Baca O., Mandelco L., Sechrest J.E., Weiss E., Woese C.R. Phylogenetic diversity of the Rickettsiae // J. Bacteriol. — 1989. — Vol. 171. — P. 4202–4206.
  55. Willems H., Ritter M., Thiele D. Plasmid-homologous sequences in the chromosome of plasmidless Coxiella burnetii Scurry Q217 // J. Bacteriol. — 1997. — Vol. 179. — P. 329–337.
  56. Woldehiwet Z. Q fever (coxiellosis): epidemiology and pathogenesis // J. Res. Vet. Sci. — 2004. — Vol. 77. — P. 93–100.
  57. Young D. Prospects for molecular epidemiology of leprosy // J. Lepr. Rev. — 2003. — Vol. 74. — P. 11–17.

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