СHROMOSOMALLY INTEGRATED HUMAN HERPESVIRUS 6
- Authors: Nikolskiy M.A.1, Golubcova V.S.1
-
Affiliations:
- 197022, Russian Federation, St. Petersburg, L’va Tolstogo str., 6/8, Pavlov First St. Petersburg State Medical University.
- Issue: Vol 5, No 1 (2015)
- Pages: 7-14
- Section: REVIEWS
- Submitted: 21.04.2015
- Accepted: 21.04.2015
- Published: 21.04.2015
- URL: https://iimmun.ru/iimm/article/view/268
- DOI: https://doi.org/10.15789/2220-7619-2015-1-7-14
- ID: 268
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Full Text
Abstract
The review focuses on the problem of chromosomally integrated human herpesvirus 6 (CIHHV-6). The main features of CIHHV-6 are wide prevalence (near 1% of population), ability to inheritance, which leads to problems of diagnostics of acute HHV-6 infection. Also there is the opportunity of activation CIHHV-6, linked to immunodeficiency and conditions after transplantation. Potentially CIHHV-6 can be associated with the abnormalities of nervous system development, autoimmune disorders and conditions, related to damage of telomere.
About the authors
M. A. Nikolskiy
197022, Russian Federation, St. Petersburg, L’va Tolstogo str., 6/8, Pavlov First St. Petersburg State Medical University.
Author for correspondence.
Email: nicolm@inbox.ru
PhD (Medicine), Assistant Professor, Department of Pediatrics, Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation;
V. S. Golubcova
197022, Russian Federation, St. Petersburg, L’va Tolstogo str., 6/8, Pavlov First St. Petersburg State Medical University.
Email: fake@neicon.ru
Intern of the Department of Pediatrics, Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation.
References
- Никольский М.А., Соколова Е.Д., Вязовая А.А., Минченко С.И., Нарвская О.В. Внезапная экзантема у госпитализированных детей грудного и раннего возраста // Педиатрия. 2013. Т. 92, No 1. С. 27–30. [Nikolsky M.A., Sokolova E.D., Vyazovaya A.A., Minchenko S.I., Narvskaya O.V. Roseola infantum among hospitalized young children. Pediatriya = Pediatrics. 2013, vol. 92, no. 1, pp. 27–30. (In Russ.)]
- Никольский М.А., Радыш М.В. Роль вирусов герпеса человека 6-го и 7-го типов в возникновении фебрильных судорог у детей // Вопросы диагностики в педиатрии. 2012. Т. 4, No 4. С. 46–48 [Nikolsky M.A., Radysh M.V. The role of human herpes viruses, type 6 and 7, in the development of febrile seizures in children. Voprosy diagnostiki v pediatrii = The Diagnostics in Pediatrics. 2012, vol. 4, no. 4, pp. 46–48. (In Russ.)]
- Никольский М.А., Мессорош В.Г., Минченко С.И. Сероконверсия и нарастание концентрации IgG-антител при инфекции, вызванной вирусом герпеса 6-го типа у детей // Эпидемиология и инфекционные болезни. 2008. No 4. С. 22–24. [Nikolsky M.A., Messorosh V.G., Minchenko S.I. Seroconversion and rising IgG antibody concentrations in herpesvirus type 6 in children. Epidemiologiya i infektsionnye bolezni = Epidemiology and Infectious Diseases. 2008, no. 4, pp. 22–24. (In Russ.)]
- Arbuckle J.H., Medveczky P.G. The molecular biology of human herpesvirus-6 latency and telomere integration. Microbes Infect., 2011, vol. 13, no. 9, pp. 731–741.
- Bates M., Monze M., Bima H. Predominant human herpesvirus 6 variant A infant infections in an HIV-1 endemic region of SubSaharan Africa. J. Med. Virol, 2009, vol. 81, no. 5, pp. 779–789.
- Bhupesh K.P., Krohne G., Rudel T. Reactivation of chromosomally integrated human herpesvirus-6 by telomeric circle formation. PLOS Genet., 2013, vol. 9, no. 12. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868596/pdf/pgen.1004033.pdf.
- Caserta M.T., Hall C.B., Schnabel K. Diagnostic assays for active infection with human herpesvirus 6 (HHV-6). J. Clin. Virol., 2010, vol. 48, no. 1, pp. 55–57.
- Daibata M., Taguchi T., Sawada T. Chromosomal transmission of human herpesvirus 6 DNA in acute lymphoblastic leukaemia. Lancet, 1998, vol. 352, no. 9127, pp. 543–544.
- Daibata M., Taguchi T., Nemoto Y. Inheritance of chromosomally integrated human herpesvirus 6 DNA. Blood, 1999, vol. 94, no. 5, pp. 1545–1549.
- De Bolle L., Naesens L., Clercq E. Update on human herpesvirus 6 biology, clinical features, and therapy. Clin. Microbiol. Rev., 2005, vol. 18, no. 1, pp. 217–245.
- Endo A., Watanabe K., Ohye T., Suzuki K., Matsubara T., Shimizu N., Kurahashi H., Yoshikawa T., Katano H., Inoue N., Imai K., Takagi M., Morio T., Mizutani S. Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency. Clin. Infect. Dis., 2014, vol. 59 (4), pp. 545–548.
- FlamandL.,LautenschlagerI.,KruegerG.HumanherpesvirusesHHV-6A,HHV-6B,andHHV-7.Diagnosisandclinicalmanagement: 3rd ed. USA: Elsevier, 2014, 333 p.
- GodetA.N.,SoignonG.,KoubiH.,BonnafousP.,AgutH.,PoirotC.,Gautheret-DejeanA.PresenceofHHV-6genomeinspermatozoa in a context of couples with low fertility: what type of infection? Andrologia, 2014. [Epub ahead of print]
- Gravel A., Hall C.B., Flamand L. Sequence analysis of transplacentally acquired human herpesvirus 6 DNA is consistent with transmission of a chromosomally integrated reactivated virus. J. Infect. Dis., 2013, vol. 207, no. 10, pp. 1585–1589.
- Grinde B. Herpesviruses: latency and reactivation — viral strategies and host response. J. Oral. Microbiol, 2013, vol. 5. Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809354/pdf/JOM-5-22766.pdf.
- Hall C.B., Caserta M.T., Schnabel K.C. Transplacental congenital human herpesvirus 6 infection caused by maternal chromosomally integrated virus. J. Infect. Dis., 2010, vol. 15, no. 4, pp. 505–507.
- Henderson T.A. Valacyclovir treatment of chronic fatigue in adolescents. Adv. Mind. Body Med., 2014, vol. 28 (1), pp. 4–14.
- Jarrett R.F., Gledhill S., Qureshi F., Crae S.H., Madhok R., Brown I. Identification of human herpesvirus 6-specific DNA sequences in two patients with non-Hodgkin’s lymphoma. Leukemia, 1988, vol. 2, no. 8, pp. 496–502.
- JeulinH.,AgrinierN.,GueryM.,SalmonA.,ClémentL.,BordigoniP.,VenardV.Humanherpesvirus6infectionafterallogeneic stem cell transplantation: incidence, outcome, and factors associated with HHV-6 reactivation. Transplantation, 2013, vol. 95 (10), pp. 1292–1298.
- Kainth M.K., Fisher S.G., Fernandez D., Luque A., Hall C.B., Hoang A.T., Lashkari A., Peck A., Hasan L., Caserta M.T. Understanding the association between chromosomally integrated human herpesvirus 6 and HIV disease: a cross-sectional study. F1000Res., 2013, no. 9, pp. 261–269.
- LeeS.O.,BrownR.A.,RazonableR.R.Chromosomallyintegratedhumanherpesvirus-6intransplantrecipients.Transpl.Infect. Dis., 2012, vol. 14, no. 4, pp. 346–354.
- LeibovitchE.C.,BrunettoG.S.,CarusoB.Сoinfectionofhumanherpesviruses6A(HHV-6A)andHHV-6Basdemonstratedby novel digital droplet PCR assay. PLOS One, 2014, vol. 9 (3). Available at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963908/pdf/ pone.0092328.pdf.
- Ljungman P., Camara R., Cordonnier C., Einsele H., Engelhard D., Reusser P. Management of CMV, HHV-6, HHV-7 and Kaposi’s sarcoma herpesvirus (HHV-8) infections in patients with hematological malignancies and after SCT. Bone Marrow Transplant., 2008, vol. 42, no. 4, pp. 227–240.
- Luppi M., Marasca R., Barozzi P., Ferrari S., Ceccherini-Nelli L., Batoni G. Three cases of human herpesvirus-6 latent infection: integration of viral genome in peripheral blood mononuclear cell DNA. J. Med. Virol., 1993, vol. 40, no. 1, pp. 44–52.
- Montoya J.G., Neely M.N., Gupta S. Antiviral therapy of two patients with chromosomally-integrated human herpesvirus-6A presenting with cognitive dysfunction. J. Clin. Virol., 2012, vol. 55, no. 1, pp. 40–45.
- Morissette G., Flamand L. Herpesviruses and chromosomal integration. J. Virol., 2010, vol. 84, no. 23, pp. 12100–12109.
- OhyeT.,InagakiH.,IhiraM.Dualrolesforthetelomericrepeatsinchromosomallyintegratedhumanherpesvirus-6.Sci.Rep., 2014, no. 4, pp. 4550–4559.
- Oikawa J., Tanaka J., Yoshikawa T. An immunocompetent child with chromosomally integrated human herpesvirus 6B accidentally identified during the care of Mycoplasma pneumoniae infection. J. Infect. Chemother., 2014, vol. 20, no. 1, pp. 65–67.
- PantryS.N.,MedveczkyM.M.,ArbuckleJ.H.Persistenthumanherpesvirus-6infectioninpatientswithaninheritedformofthe virus. J. Med. Virol., 2013, vol. 85, no. 11, pp. 1940–1946.
- Pellett P.E., Ablashi D.V., Ambros P.F., Agut H., Caserta M.T., Descamps V., Flamand L., Gautheret-Dejean A., Hall C.B., Kamble R.T., Kuehl U., Lassner D., Lautenschlager I., Loomis K.S., Luppi M., Lusso P., Medveczky P.G., Montoya J.G., Mori Y., Ogata M., Pritchett J.C., Rogez S., Seto E., Ward K.N., Yoshikawa T., Razonable R. Chromosomally integrated human herpesvirus 6: questions and answers. Rev. Med. Virol., 2012, vol. 22, no. 3, pp. 144–155.
- Salahuddin S.Z., Ablashi D.V., Markham P.D., Josephs S.F., Sturzenegger S., Kaplan M., Halligan G., Biberfeld P., WongStaal F., Kramarsky B., Gallo R.C. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science, 1986, vol. 234, pp. 596–601.
- Singh R., Gardner R.J., Crossland K.M. Chromosomal abnormalities and epilepsy: a review for clinicians and gene hunters. Epilepsia, 2002, vol. 43, no. 2, pp. 127–140.
- StrengerV.,CaselliE.,LautenschlagerI.,SchwingerW.,AberleS.W.,LoginovR.,GentiliV.,NachevaE.,DiLucaD.,UrbanC. Detection of HHV-6-specific mRNA and antigens in PBMCs of individuals with chromosomally integrated HHV-6 (ciHHV-6). Clin. Microbiol. Infect., 2014, vol. 20 (10), pp. 1027–1032.
- ThomsonB.J.,EfstathiouS.,HonessR.W.Acquisitionofthehumanadeno-associatedvirustype-2repgenebyhumanherpesvirus type-6. Nature, 1991, vol. 351, no. 6321, pp. 78–80.
- Tohyama M., Hashimoto K., Yasukawa M. Association of human herpesvirus 6 reactivation with the flaring and severity of druginduced hypersensitivity syndrome. Br. J. Dermatol., 2007, vol. 157, no. 5, pp. 934–940.
- TorelliG.,MarascaR.,LuppiM.,SelleriL.,FerrariS.,NarniF.,MarianoM.T.,FedericoM.,Ceccherini-NelliL.,BendinelliM. Human herpesvirus-6 in human lymphomas: identification of specific sequences in Hodgkin’s lymphomas by polymerase chain reaction. Blood, 1991, vol. 77, no. 10, pp. 2251–2258.
- TrempeF.,MorissetteG.,GravelA.EnzymaticandbiologicalpropertiesofHHV-6U94/repprotein.8thInternationalConference on HHV-6 and -7. Paris, France, April 8–10, 2013, Abstract #2–1.
- Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses. Elsevier Science, 2012, 1338 p.
- WangZ.,DengZ.,LiebermanP.M.Telomeresandviruses:commonthemesofgenomemaintenance.Front.Oncol.,2012,vol.31, no. 2, pp. 201.
- WardK.N.,LeongH.N.,NachevaE.P.,HowardJ.,AtkinsonC.E.,DaviesN.W.,GriffithsP.D.,ClarkD.A.Humanherpesvirus6 chromosomal integration in immunocompetent patients results in high levels of viral DNA in blood, sera, and hair follicles. J. Clin. Microbiol., 2006, vol. 44, no. 4, pp. 1571–1574.
- Yamanishi K., Okuno T., Shiraki K., Takahashi M., Kondo T., Asano Y., Kurata T. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet, 1988, no. 1, pp. 1065–1067.