Russian Journal of Infection and ImmunityRussian Journal of Infection and ImmunityИнфекция и иммунитет2220-76192313-7398SPb RAACI26810.15789/2220-7619-2015-1-7-14REVIEWSОБЗОРЫСHROMOSOMALLY INTEGRATED HUMAN HERPESVIRUS 6ХРОМОСОМНО-ИНТЕГРИРОВАННЫЙ ВИРУС ГЕРПЕСА ЧЕЛОВЕКА 6 ТИПАNikolskiyM. A.НикольскийМ. А.
Russian Federation

PhD (Medicine), Assistant Professor, Department of Pediatrics, Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation;

к.м.н., ассистент кафедры педиатрии ПСПбГМУ им. акад. И.П. Павлова, Санкт-Петербург, Россия; 

nicolm@inbox.ruGolubcovaV. S.ГолубцоваВ. С.
Russian Federation

Intern of the Department of Pediatrics, Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation.

интерн кафедры педиатрии ПСПбГМУ им. акад. И.П. Павлова, Санкт-Петербург, Россия. 

197022, Russian Federation, St. Petersburg, L’va Tolstogo str., 6/8, Pavlov First St. Petersburg State Medical University.197022, Россия, Санкт-Петербург, ул. Льва Толстого, 6/8, ПСПбГМУ им. акад. И.П. Павлова.21042015517142104201521042015Copyright ©; 2015, Nikolskiy M.A., Golubcova V.S.Copyright ©; 2015, Никольский М.А., Голубцова В.С.2015Nikolskiy M.A., Golubcova V.S.Никольский М.А., Голубцова В.С.https://creativecommons.org/licenses/by/4.0https://iimmun.ru/iimm/article/view/268

The review focuses on the problem of chromosomally integrated human herpesvirus 6 (CIHHV-6). The main features of CIHHV-6 are wide prevalence (near 1% of population), ability to inheritance, which leads to problems of diagnostics of acute HHV-6 infection. Also there is the opportunity of activation CIHHV-6, linked to immunodeficiency and conditions after transplantation. Potentially CIHHV-6 can be associated with the abnormalities of nervous system development, autoimmune disorders and conditions, related to damage of telomere. 

Обзор посвящен хромосомно-интегрированной форме вируса герпеса человека 6 типа (хиВГЧ-6). Особенностью хиВГЧ-6 является его широкое распространение (до 1% населения), возможность передачи по наследству, проблемы диагностики, в том числе вопросы дифференциального диагноза с острой формой ВГЧ-6 инфекции, что, в свою очередь, приводит к сложности решения вопроса о необходимости терапии. С другой стороны, возможна активация хиВГЧ-6, особенно у пациентов после трансплантации костного мозга (ТКМ), с появлением клиники острой инфекции и необходимостью противовирусной терапии. В литературе обсуждается возможность наличия фенотипических особенностей у людей с хиВГЧ-6, в том числе особенностей развития нервной системы, риска возникновения аутоиммунных заболеваний и синдромов, связанных с нарушением нормальной структуры теломер. 

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