INFLUENCE OF EXCESSIVE PRO-INFLAMMATORY IMMUNE RESPONSE ON IMMUNOLOGICAL PARAMETERS IN WOMEN WITH EARLY MISCARRIAGES



Cite item

Full Text

Abstract

Abstract

The study results showed that in the early pregnancy (up to 12 weeks) in women with a full-term pregnancy, but suffering from genital infections, changes occur in cellular immune arm. Such alterations affect both innate and adaptive immunity due to activated inflammatory reactions. At the same time, despite detected infection, pregnancy in such women may progression without serious disturbances. However, studies have shown that much more prominent changes in immune system are observed in women with former miscarriages, if they also suffer from genital infections.

In women with miscarriages paralleled with genital infections, changes in the immune system are more pronounced that may be accounted for by ongoing immune response hyperreactivity. The latter is referred to an excessive reaction of the immune system to ongoing infection that results in higher inflammation. Such excessive inflammatory processes can cause a disrupted normal mechanisms of pregnancy maintenance, which in turn contributes to increased risk of pregnancy termination, as is observed in miscarriages.

In addition, a more pronounced imbalance between pro-inflammatory and anti-inflammatory interleukins is observed in women with miscarriage. Pro-inflammatory interleukins (such as IL-6, IL-1β) potentiate inflammation and may increase the risk of complications during pregnancy, including miscarriage. Anti-inflammatory interleukins, on the other hand, should maintain balance in immune system and counter inflammation, but in case of women with former miscarriage, their activity is insufficient to counteract infection-related inflammatory processes.

Thus, the presence of genital infections in women with former miscarriage often leads to excessive immune system activity, which contributes to increased inflammation and disrupted physiological processes that support pregnancy. In such cases, immune response is inadequate and exuberant that may contribute to pregnancy loss.

About the authors

Vladimir Alekseevich Aleynik

Andijan State Medical Institute, Andijan, Republic of Uzbekistan;
Andijan Branch of the Institute of Human Immunology and Genomics, Andijan, Republic of Uzbekistan

Email: aleynik.vladimir@mail.ru

Doctor of Medicine, Professor, Department of Normal Physiology, Andijan State Medical Institute, Andijan, Republic of Uzbekistan;

Director of the Andijan Branch of the Institute of Immunology and Human Genomics, Academy of Sciences of the Republic of Uzbekistan, Andijan

Узбекистан, 1 Atabekov Street

Mokhigul Zhuraeva

Andijan State Medical Institute, Andijan, Republic of Uzbekistan

Email: mohigul_azimovna@mail.ru
ORCID iD: 0000-0002-8338-1122

Doctor of Medicine, Professor, Department of Training of Family Doctors, Andijan State Medical Institute, Andijan, Republic of Uzbekistan

Узбекистан, улица Атабекова 1

Kamola Oybekovna Muxitdinova

Andijan State Medical Institute, Andijan, Republic of Uzbekistan

Email: kamosha.muxitdinov@mail.ru

Ph.D., Assistant, Department of Obstetrics and Gynecology No. 2, Andijan State Medical Institute, Andijan, Republic of Uzbekistan

Узбекистан, Atabekov strire 1

Svetlana Mixaylovna Babich

Andijan State Medical Institute, Andijan, Republic of Uzbekistan

Email: mohigul_azimovna@mail.ru

PhD, Associate Professor, Head of the Department of Social Hygiene and Health Management, Andijan, Republic of Uzbekistan

Узбекистан, Atabekov strite 1

Xabiba Nabievna Negmatshayeva

Andijan State Medical Institute, Andijan, Republic of Uzbekistan

Author for correspondence.
Email: mohigul_azimovna@mail.ru

Candidate of Medical Sciences, Associate Professor, Head of the Department of Obstetrics and Gynecology No. 2, Andijan, Republic of Uzbekistan

Узбекистан, Atabekov 1 strite

References

  1. Areia A. L., Mota-Pinto A. Inflammation and preterm birth: a systematic review //Reproductive Medicine. – 2022. – Т. 3. – №. 2. – С. 101-111 Areia A. L., Mota-Pinto A. Inflammation and preterm birth: a systematic review //Reproductive Medicine. – 2022. – Т. 3. – №. 2. – С. 101-111 doi.org/10.3390/reprodmed3020009
  2. Daskalakis, G., Psarris, A., Koutras, A., Fasoulakis, Z., Prokopakis, I., Varthaliti, A., ... &Papapanagiotou, A. Maternal infection and preterm birth: from molecular basis to clinical implications //Children. – 2023. – Т. 10. – №. 5. – С. 907. Daskalakis, G., Psarris, A., Koutras, A., Fasoulakis, Z., Prokopakis, I., Varthaliti, A., ... &Papapanagiotou, A. Maternal infection and preterm birth: from molecular basis to clinical implications //Children. – 2023. – Т. 10. – №. 5. – С. 907. doi.org/10.3390/children10050907
  3. Equils, O., Kellogg, C., McGregor, J., Gravett, M., Neal-Perry, G., &Gabay, C. The role of the IL-1 system in pregnancy and the use of IL-1 system markers to identify women at risk for pregnancy complications //Biology of reproduction. – 2020. – Т. 103. – №. 4. – С. 684-694. Equils, O., Kellogg, C., McGregor, J., Gravett, M., Neal-Perry, G., &Gabay, C. The role of the IL-1 system in pregnancy and the use of IL-1 system markers to identify women at risk for pregnancy complications //Biology of reproduction. – 2020. – Т. 103. – №. 4. – С. 684-694. doi.org/10.1093/biolre/ioaa102
  4. Huang, Q., Li, P., Zheng, Z., Sha, X., Wang, L., Lin, B., ... & Liu, H. The synergistic effects of prostaglandin and IL-1β on myometrial and cervical stromal cells at the onset of labor //Cytokine. – 2025. – Т. 190. – С. 156927. Huang, Q., Li, P., Zheng, Z., Sha, X., Wang, L., Lin, B., ... & Liu, H. The synergistic effects of prostaglandin and IL-1β on myometrial and cervical stromal cells at the onset of labor //Cytokine. – 2025. – Т. 190. – С. 156927 doi.org/10.1016/j.cyto.2025.156927
  5. Kumar M., Saadaoui M., Al Khodor S. Infections and pregnancy: effects on maternal and child health //Frontiers in Cellular and Infection Microbiology. – 2022. – Т. 12. – С.873253. Kumar M., Saadaoui M., Al Khodor S. Infections and pregnancy: effects on maternal and child health //Frontiers in Cellular and Infection Microbiology. – 2022. – Т. 12. – С.873253. doi.org/10.3389/fcimb.2022.873253
  6. Nedeva C. Inflammation and cell death of the innate and adaptive immune system during sepsis //Biomolecules. – 2021. – Т. 11. – №. 7. – С. 1011. Nedeva C. Inflammation and cell death of the innate and adaptive immune system during sepsis //Biomolecules. – 2021. – Т. 11. – №. 7. – С. 1011. doi.org/10.3390/biom11071011
  7. Socha, M. W., Flis, W., Pietrus, M., Wartęga, M., &Stankiewicz, M. Signaling pathways regulating human cervical ripening in preterm and term delivery //Cells. – 2022. – Т. 11. – №. 22. – С. 3690. Socha, M. W., Flis, W., Pietrus, M., Wartęga, M., &Stankiewicz, M. Signaling pathways regulating human cervical ripening in preterm and term delivery //Cells. – 2022. – Т. 11. – №. 22. – С. 3690. doi.org/10.3390/cells11223690
  8. Zeng, F., Li, Y., Zhang, X., Shen, L., Zhao, X., Beta, T., ... & Huang, W. Immune regulation and inflammation inhibition of Arctiumlappa L. polysaccharides by TLR4/NF-κB signaling pathway in cells //International Journal of Biological Macromolecules. – 2024. – Т. 254. – С. 127700. Zeng, F., Li, Y., Zhang, X., Shen, L., Zhao, X., Beta, T., ... & Huang, W. Immune regulation and inflammation inhibition of Arctiumlappa L. polysaccharides by TLR4/NF-κB signaling pathway in cells //International Journal of Biological Macromolecules. – 2024. – Т. 254. – С. 127700. doi.org/10.1016/j.ijbiomac.2023.127700
  9. Equils, O., Kellogg, C., McGregor, J., Gravett, M., Neal-Perry, G., &Gabay, C. The role of the IL-1 system in pregnancy and the use of IL-1 system markers to identify women at risk for pregnancy complications //Biology of reproduction. – 2020. – Т. 103. – №. 4. – С. 684-694. Equils, O., Kellogg, C., McGregor, J., Gravett, M., Neal-Perry, G., &Gabay, C. The role of the IL-1 system in pregnancy and the use of IL-1 system markers to identify women at risk for pregnancy complications //Biology of reproduction. – 2020. – Т. 103. – №. 4. – С. 684-694. doi.org/10.1093/biolre/ioaa102

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) Aleynik V.A., Aleynik V.A., Zhuraeva M., Muxitdinova K.O., Muxitdinova K.O., Babich S.M., Babich S.M., Nigmatshayeva X.N., Nigmatshayeva X.N.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 64788 от 02.02.2016.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies