THE INTERDEPENDENCE OF THE CYTOKINE STATUS AND THE SEVERITY OF INTOXICATION SYNDROME IN INFLUENZA

Cover Page

Cite item

Abstract

Abstract. The goal of study was to evaluate cytokines level in blood of 60 patients with uncomplicated influenza and its relations with severity of intoxication symptoms. High level of TNFα, IL-10, IL-1Rа and low level of IFNγ was measured in serum of patients with severe intoxication syndrome during acute phase of disease. The duration of intoxication syndrome of influenza had a direct correlation with the concentration of TNFα, IL-6, IL-8, IL-1Rа, IL-10 and the opposite of IL-1β.

About the authors

L. V. Voloschcuk

Ministry of Health of the Russian Federation Research Institute of Influenza, Saint Petersburg

Author for correspondence.
Email: 7970747@mail.ru

PhD (Medicine), Senior Research Associate, Division of Viral Respiratory Infections in Adults

197022, Russian Federation, St. Petersburg, Professor Popov str., 15/17

 

Russian Federation

E. G. Golovacheva

Ministry of Health of the Russian Federation Research Institute of Influenza, Saint Petersburg

Email: 7970747@mail.ru
PhD (Medicine), Senior Research Associate, Division of Viral Respiratory Infections in Children Russian Federation

A. L. Mushkatina

Ministry of Health of the Russian Federation Research Institute of Influenza, Saint Petersburg

Email: 7970747@mail.ru
Research Associate, Division of Viral Respiratory Infections in Adults Russian Federation

L. V. Osidak

Ministry of Health of the Russian Federation Research Institute of Influenza, Saint Petersburg

Email: 7970747@mail.ru
PhD, MD (Medicine), Professor, Leading Research Associate, Division of Viral Respiratory Infections in Children Russian Federation

P. V. Zarishnuk

Ministry of Health of the Russian Federation Research Institute of Influenza, Saint Petersburg

Email: 7970747@mail.ru
Senior Research Associate, Division of Viral Respiratory Infections in Adults Russian Federation

A. A. Go

Ministry of Health of the Russian Federation Research Institute of Influenza, Saint Petersburg

Email: 7970747@mail.ru
Chief, Division of Viral Respiratory Infections in Adults Russian Federation

References

  1. Ершов Ф.И. Система интерферона в норме и при патологии. — М.: Медицина, 1996. — 240 с. Ershov F.I. Sistema interferona v norme i pri patologii [The interferon system in norm and pathology]. Мoscow, Meditsina, 1996. 240 p.
  2. Инфекционная заболеваемость за январь–декабрь 2008 г. в Российской Федерации // Детские инфекции. — 2009. — Т. 8. — С. 1–3. Infektsionnaya zabolevaemost` za yanvar`-dekabr` 2008 g. v Rossiyskoy Federatsii [Infection diseases morbidity in January-December, 2008 in the Russian Federation]. Detskie infektsii — Children Infections, 2009, vol. 8, pp. 1–3.
  3. Кетлинский С.А. Роль интерферонов I типа в регуляции иммунного ответа // Вопросы общей вирусологии: учебное пособие; под ред. О.И. Киселева. — СПб.: СПбГМА им. И.И. Мечникова. — 2007. — С. 130–140. Ketlinskiy S.A. Rol` interferonov I tipa v regulyatsii immunnogo otveta [The role of interferon 1 type in the immune response regulations]. Voprosy obshchey virusologii (Pod red. O.I. Kiseleva) [The problems of general virology (Ed. by O.I. Kiselev)]. St. Petersburg, SPbGMA im. I.I. Mechnikova Publ., 2007, pp. 130–140.
  4. Кетлинский С.А., Симбирцев А.С. Цитокины. — СПб.: ООО «Издательство Фолиант», 2008. — 552 с. Ketlinskiy S.A., Simbirtsev A.S. Tsitokiny [Citokines]. St. Petersburg, Foliant, 2008. 552 p.
  5. Медицинская вирусология / Под ред. Д.К. Львова. — М.: МИА, 2008. — 655 с. Meditsinskaya virusologiya (Pod red. D.K. L`vova) [Medical virology (Ed. by D.K. Lvov)]. Moscow, MIA Publ., 2008. 655 p.
  6. Пинегин Б.В. Принципы применения иммуномодуляторов в комплексном лечении инфекционных процессов // Лечащий врач. — 2000. — № 8. — С. 34–38. Pinegin B.V. Printsipy primeneniya immunomodulyatorov v kompleksnom lechenii infektsionnykh protsessov [The principles of immunomodulator using in complex treatment of infectious processes]. Lechashchiy vrach — Doctor in Charge, 2000, no. 8, pp. 34–38.
  7. Сенников С.В., Силков А.Н. Методы определения цитокинов // Цитокины и воспаление. — 2005. — Т. 4, № 1. — С. 22–27. Sennikov S.V., Silkov A.N. Metody opredeleniya tsitokinov [Methods of cytokines detection]. Tsitokiny i vospalenie — Citokines and Inflammation, 2005, vol. 4, no. 1, pp. 22–27.
  8. Aydin M., Ozkok E., Ozturk O., Agachan B., Yilmaz H., Yaylim I., Kebabcioglu S., Ispir T. Relationship between interleukin-8 and the oxidant-antioxidant system in end-stage renal failure patients. Exp. Clin. Transplant., 2007, vol. 5 (1), pp. 610–613.
  9. Flory E., Kunz M., Scheller C., Jassoy C., Stauber R., Rapp U.R., Ludwig S. Influenza virus-induced NF-κB-dependent gene expression is mediated by overexpression of viral proteins and involves oxidative radicals and activation of IκB kinase. J. Biol. Chem., 2000, vol. 275, pp. 8307–8314.
  10. Foey A.D., Parry S.L., Williams L.M., Feldmann M., Foxwell B.M., Brennan F.M. Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNFalpha: role of the p38 and p42/44 mitogenactivated protein kinases. J. Immunol., 1998, vol. 160 (2), pp. 920–928.
  11. Jenkins J.K., Malyak M., Arend W.P. The effects of interleukin-10 [IL-10] on interleukin-1 receptor antagonist and interleukin-1 beta production in human monocytes and neutrophils. Lymphokine Cytokine Res., 1994, vol. 13, pp. 47–49.
  12. Longini I.M. Jr, Halloran M.E., Nizam A., Yang Y. Containing pandemic influenza with antiviral agents. Am. J. Epidemiol., 2004, vol. 159, pp. 623–633.
  13. Wang Y., Xu W., Sun X. Fever of recombinant human interferon-alpha is mediated by opioid domain interaction with opioid receptor inducing prostaglandin E2. J. Neuroimmunol., 2004, vol. 156 (1–2), pp. 107–112.

Copyright (c) 2014 Voloschcuk L.V., Golovacheva E.G., Mushkatina A.L., Osidak L.V., Zarishnuk P.V., Go A.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies