THE INTERDEPENDENCE OF THE CYTOKINE STATUS AND THE SEVERITY OF INTOXICATION SYNDROME IN INFLUENZA

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Abstract

Abstract. The goal of study was to evaluate cytokines level in blood of 60 patients with uncomplicated influenza and its relations with severity of intoxication symptoms. High level of TNFα, IL-10, IL-1Rа and low level of IFNγ was measured in serum of patients with severe intoxication syndrome during acute phase of disease. The duration of intoxication syndrome of influenza had a direct correlation with the concentration of TNFα, IL-6, IL-8, IL-1Rа, IL-10 and the opposite of IL-1β.

About the authors

L. V. Voloschcuk

Ministry of Health of the Russian Federation Research Institute of Influenza, Saint Petersburg

Author for correspondence.
Email: 7970747@mail.ru

PhD (Medicine), Senior Research Associate, Division of Viral Respiratory Infections in Adults

197022, Russian Federation, St. Petersburg, Professor Popov str., 15/17

 

Россия

E. G. Golovacheva

Ministry of Health of the Russian Federation Research Institute of Influenza, Saint Petersburg

Email: 7970747@mail.ru
PhD (Medicine), Senior Research Associate, Division of Viral Respiratory Infections in Children Россия

A. L. Mushkatina

Ministry of Health of the Russian Federation Research Institute of Influenza, Saint Petersburg

Email: 7970747@mail.ru
Research Associate, Division of Viral Respiratory Infections in Adults Россия

L. V. Osidak

Ministry of Health of the Russian Federation Research Institute of Influenza, Saint Petersburg

Email: 7970747@mail.ru
PhD, MD (Medicine), Professor, Leading Research Associate, Division of Viral Respiratory Infections in Children Россия

P. V. Zarishnuk

Ministry of Health of the Russian Federation Research Institute of Influenza, Saint Petersburg

Email: 7970747@mail.ru
Senior Research Associate, Division of Viral Respiratory Infections in Adults Россия

A. A. Go

Ministry of Health of the Russian Federation Research Institute of Influenza, Saint Petersburg

Email: 7970747@mail.ru
Chief, Division of Viral Respiratory Infections in Adults Россия

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Copyright (c) 2014 Voloschcuk L.V., Golovacheva E.G., Mushkatina A.L., Osidak L.V., Zarishnuk P.V., Go A.A.

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