CLINICAL SIGNIFICANCE OF CYTOKINES SERUM LEVELS IN CHILDREN WITH CHICKEN POX

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Abstract

The serum levels of cytokines IL-1β, IL-8, IL-6, IFNα, IFNγ, IL-4, IL-10 were tested in ELISA in 74 children with different courses of chicken pox. Moderate severity course of chicken pox was accompanied by significant increase of IL-1β, IL-8, IFNα, IFNγ, IL-10 levels, but severe course of infection was associated with cytokine response reduction. Manifestation of varicella-zoster virus encephalitis was accompanied by the rise of IL-1β, IL-6, IFNγ and IL-10 levels during the second week of disease. 

About the authors

G. F. Zheleznikova

195267, Russian Federation, St. Petersburg, Acad. Konstantinov str., 12/80. Science Research Institute of Children’s Infections

Author for correspondence.
Email: zheleznikova.galina@gmail.com

PhD, MD (Medicine), Professor, Senior Research Associate, Department of Clinical Laboratory Diagnostic, Institute of Children’s Infections, St. Petersburg, Russian Federation; 

Russian Federation

Y. V. Lobzin

195267, Russian Federation, St. Petersburg, Acad. Konstantinov str., 12/80. Science Research Institute of Children’s Infections

Email: fake@neicon.ru

PhD, MD (Medicine), Professor, Full Member of the Russian Academy of Sciences, Director of Institute of Children’s Infections, St. Petersburg, Russian Federation; 

Russian Federation

N. V. Skripchenko

195267, Russian Federation, St. Petersburg, Acad. Konstantinov str., 12/80. Science Research Institute of Children’s Infections
St. Petersburg State Pediatric Medical University, St. Petersburg, Russia

Email: fake@neicon.ru

PhD, MD (Medicine), Professor, Deputy Director for Scientific Work, Institute of Children’s Infections; Head of the Department of Children’s Infectious Diseases, St. Petersburg State Pediatric Medical University of Public Health Ministry of Russia, St. Petersburg, Russian Federation;

Russian Federation

G. P. Ivanova

195267, Russian Federation, St. Petersburg, Acad. Konstantinov str., 12/80. Science Research Institute of Children’s Infections
St. Petersburg State Pediatric Medical University, St. Petersburg, Russia

Email: fake@neicon.ru

PhD, MD (Medicine), Leading Researcher, Head of the Department of Intensive Therapy in Urgent Cases, Institute
of Children’s Infections; Assistant Professor of the Department of Children’s Infectious Diseases, St. Petersburg State Pediatric Medical University of Public Health Ministry of Russia, St. Petersburg, Russian Federation;

Russian Federation

E. Y. Skripchenko

St. Petersburg State Pediatric Medical University, St. Petersburg, Russia
City Clinical Hospital No. 31, St. Petersburg, Russia

Email: fake@neicon.ru

PhD (Medicine), Assistant Professor of the Department of Psychoneurology, St. Petersburg State Pediatric Medical University of Public Health Ministry of Russia; neurologist of City Centre of Multiple Sclerosis, City Clinical Hospital No. 31, St. Petersburg, Russian Federation;

Russian Federation

N. E. Monakhova

195267, Russian Federation, St. Petersburg, Acad. Konstantinov str., 12/80. Science Research Institute of Children’s Infections

Email: fake@neicon.ru

Senior Research Associate, Department of Clinical Laboratory Diagnostic, Institute of Children’s Infections, St. Petersburg, Russian Federation. 

Russian Federation

References

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Copyright (c) 2015 Zheleznikova G.F., Lobzin Y.V., Skripchenko N.V., Ivanova G.P., Skripchenko E.Y., Monakhova N.E.

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