PECULIARITIES OF SPECIFIC HUMORAL MESLES IMMUNE RESPONSE

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Abstract. The aim of study was to investigate peculiarities of specific immune responses in vaccinated and unvaccinated measles convalescents. Twelve infants with natural measles infection at 5–7th day after onset of rash (Group 1), 14 adults with natural measles infection at 5–7th day (Group 2), 13 adults with measles at 12–15th day after onset of rash (Group 3), and 15 measles patients previously vaccinated against measles (Group 4) were examined. Fifteen healthy adults had twodose measles vaccination at 1 year and 6 years old (Group 5), and 17 healthy adults had measles many years ago (Group 6) were included in the study as a control groups. Specific IgM, IgA, IgG antibodies in serum, and their subclasses and avidity were tested by ELISA. High level of specific IgM and IgA-antibodies, and increasing of low-avidity IgG-antibodies, predominantly IgG3 subclass were typical for the humoral immune response in unvaccinated patients. On the contrary, lower level of IgM and the highest level of specific IgA and high-avidity IgG, predominantly IgG1 subclass characterized the group of previously vaccinated measles patients. The humoral immune response in vaccinated volunteers was characterized by lower level of specific IgA, IgG and avidity than in adults had measles in their childhood (group 6). The laboratory plays a critical role in case classification when rash and fever develop in persons who have possibly been exposed to measles. Waning of measles antibody, however, does not necessarily equate to waning immunity, because B-memory cells responses can increase of the antibody synthesis. 

About the authors

A. P. Toptygina

G.N. Gabrichevsky research institut for epidemiology and microbilogy, Moscow

Author for correspondence.
Email: toptyginaanna@rambler.ru

PhD (Medicine), Leading Research Associate, Laboratory of Cytokine

25212, Russian Federation, Moscow, Admiral Makarov str., 10

 

Russian Federation

T. A. Mamaeva

G.N. Gabrichevsky research institut for epidemiology and microbilogy, Moscow

Email: toptyginaanna@rambler.ru
PhD (Medicine), Leading Research Associate, Laboratory of immunochemistry Russian Federation

V. A. Alioshkin

G.N. Gabrichevsky research institut for epidemiology and microbilogy, Moscow

Email: toptyginaanna@rambler.ru
PhD, MD (Biology), Director Russian Federation

References

  1. Мамаева Т.А., Липская Г.Ю., Наумова М.А., Шульга С.В., Mulders M., Featherstone D.A., Завьялова Л.А., Чернышова Е.В., Замятина Е.П., Кузнецова Н.Н. Особенности лабораторной диагностики кори у больных с разным прививочным анамнезом // Вопр. вирусол. — 2012. — № 5. — С. 21–26. Mamaeva T.A., Lipskaya G.Yu., Naumova M.A., Shul`ga S.V., Mulders M., Featherstone D.A., Zav`yalova L.A., Chernyshova E.V., Zamyatina E.P., Kuznetsova N.N. Osobennosti laboratornoy diagnostiki kori u bol`nykh s raznym privivochnym anamnezom [Characteristics of measles laboratory diagnostics in patients with different vaccination history]. Voprosy virusologii — Problems of Virology, 2012, no. 5, pp. 21–26.
  2. Топтыгина А.П., Пухальский А.Л., Мамаева Т.А., Алешкин В.А. Спектр субклассов противокоревых иммуноглобулинов G у лиц, перенесших корь. // Бюл. эксперим. биологии. — 2004. — Т. 137, № 3. — С. 293–295. Toptygina A.P., Pukhal`skiy A.L., Mamaeva T.A., Aleshkin V.A. Spektr subklassov protivokorevykh immunoglobulinov G u lits, perenesshikh kor` [The spectrum of subclasses of measles immunoglobulin G in persons recovered from measles]. Byulleten` eksperimental`noy biologii — Bulletin of Experimental Biology, 2004, vol. 137, no. 3, pp. 293–295.
  3. Ярилин А.А. Иммунология. — М.: «ГЭОТАР-Медиа», 2010. — С. 752. Yarilin A.A. Immunologiya [Immunology]. Moscow, GEOTAR-Media, 2010. 752 p.
  4. Anis E., Grotto I., Moerman L., Warshavsky B., Slater P.E., Lev B., Israeli A. Measles in a highly vaccinated society: the 2007–08 outbreak in Israel. J. Infect., 2009, vol. 59, pp. 252–258.
  5. Bätzing-Feigenbaum J., Pruckner U., Beyer A., Sinn G., Dinter A., Mankertz A., Siedler A., Schubert A., Suckau M. Spotlight on measles 2010: preliminary report of an ongoing measles outbreak in a subpopulation with low vaccination coverage in Berlin, Germany, January-March 2010. Euro Surveill., 2010, vol. 15, pp. 19527.
  6. Chen R.T., Markowitz L.E., Albrecht P., Stewart J.A., Mofenson L.M., Preblud S.R. Orenstein W.A. Measles antibody: reevaluation of protective titers. J. Infect. Dis., 1990, vol. 162, pp. 1036–1042.
  7. Centers for Disease Control and Prevention. Multistate measles outbreak associated with an international youth sporting event — Pennsylvania, Michigan and Texas. MMWR Morb. Mortal. Wkly. Rep., 2008, vol. 57, pp. 169–173.
  8. Eaton L. Measles cases in England and Wales rise sharply in 2008. BMJ, 2009, vol. 338, pp. b533.
  9. Erdman D., Heath J.L., Watson J.C., Markowitz L.E., Bellini W. Immunoglobulin M antibody response to measles virus following primary and secondary vaccination and natural virus infection. J. Med. Virol., 1993, vol. 41, pp. 44–48.
  10. Hickman C.J., Hyde T.B., Sowers S.B., Mercader S., McGrew M., Williams N.J., Beeler J.A., Audet S., Kiehl B., Nandy R., Tamin A., Bellini W.J. Laboratory characterization of measles virus infection in previously vaccinated and unvaccinated individuals. J. Infect. Dis., 2011, vol. 204, suppl. 1, pp. 549–558.
  11. Kasper S., Holzmann H., Aberle S.W., Wassermann-Neuhold M., Gschiel H., Feenstra O. Allerberger F., Schmid D. Measles outbreak in Styria, Austria, March-May 2009. Euro Surveill., 2009, vol. 14, pp. 19347.
  12. Orenstein W.A., Strebel P.M., Papania M., Sutter R.W., Bellini W.J., Cochi S.L. Measles eradication: is it in our future? Am. L. Public Health., 2000, vol. 90, pp. 1521–1525.
  13. Ovsyannikova I.G., Jacobson R.M., Vierkant R.A., Pankratz V.S., Poland G.A. HLA supertypes and immune responses to measles-mumps-rubella viral vaccine: findings and implications for vaccine design. Vaccine, 2007, vol. 25, pp. 3090–3100.
  14. Parent du Châtelet I., Floret D., Antona D., Lévy-Bruhl D. Measles resurgence in France in 2008, a preliminary report. Euro Surveill., 2009, vol. 14, pp. 19118.
  15. Strebel P.M., Henao-Restrepo A.M., Hoekstra E., Olive J.M., Papania M.J., Cochi S.L. Global measles elimination efforts: the significance of measles elimination in the United States. J. Infect. Dis., 2004, vol. 189 [suppl. 1], pp. 251–257.
  16. Sugerman D.E., Barskey A.E., Delea M.G., Ortega-Sanchez I.R., Bi D., Ralston K.J., Rota P.A., Waters-Montijo K., Lebaron C.W. Measles outbreak in a highly vaccinated population, San Diego, 2008: role of the internationally undervaccinated. Pediatrics, 2010, vol. 125, pp. 747–755.

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