PECULIARITIES OF SPECIFIC HUMORAL MESLES IMMUNE RESPONSE

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Abstract. The aim of study was to investigate peculiarities of specific immune responses in vaccinated and unvaccinated measles convalescents. Twelve infants with natural measles infection at 5–7th day after onset of rash (Group 1), 14 adults with natural measles infection at 5–7th day (Group 2), 13 adults with measles at 12–15th day after onset of rash (Group 3), and 15 measles patients previously vaccinated against measles (Group 4) were examined. Fifteen healthy adults had twodose measles vaccination at 1 year and 6 years old (Group 5), and 17 healthy adults had measles many years ago (Group 6) were included in the study as a control groups. Specific IgM, IgA, IgG antibodies in serum, and their subclasses and avidity were tested by ELISA. High level of specific IgM and IgA-antibodies, and increasing of low-avidity IgG-antibodies, predominantly IgG3 subclass were typical for the humoral immune response in unvaccinated patients. On the contrary, lower level of IgM and the highest level of specific IgA and high-avidity IgG, predominantly IgG1 subclass characterized the group of previously vaccinated measles patients. The humoral immune response in vaccinated volunteers was characterized by lower level of specific IgA, IgG and avidity than in adults had measles in their childhood (group 6). The laboratory plays a critical role in case classification when rash and fever develop in persons who have possibly been exposed to measles. Waning of measles antibody, however, does not necessarily equate to waning immunity, because B-memory cells responses can increase of the antibody synthesis. 

About the authors

A. P. Toptygina

G.N. Gabrichevsky research institut for epidemiology and microbilogy, Moscow

Author for correspondence.
Email: toptyginaanna@rambler.ru

PhD (Medicine), Leading Research Associate, Laboratory of Cytokine

25212, Russian Federation, Moscow, Admiral Makarov str., 10

 

Россия

T. A. Mamaeva

G.N. Gabrichevsky research institut for epidemiology and microbilogy, Moscow

Email: toptyginaanna@rambler.ru
PhD (Medicine), Leading Research Associate, Laboratory of immunochemistry Россия

V. A. Alioshkin

G.N. Gabrichevsky research institut for epidemiology and microbilogy, Moscow

Email: toptyginaanna@rambler.ru
PhD, MD (Biology), Director Россия

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