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Abstract. The immune status and the level of specific antibodies to Cytomegalovirus (121 patients) or Mycoplasma pneumoniae (129 patients) were tested in 250 patients aged 19–56 years old. This cohort was divided for three groups. Seventy eight patients with low level of CD3+CD4+ lymphocytes and normal rates of other parameters of immune status were jointed in Group 1. The second group was presented by 85 patients with low level of CD3+CD4+ and high level of CD3+CD8+ lymphocytes. Eighty seven patients with lymphopenia were distinguished in Group 3. All patients were treated with antiviral or antibacterial and immunomodulatory drugs. Three schemes of immunomodulatory therapy including imunofanum, polyoxidonium, cycloferonum, glutoxim, immunomax in different combination were used. In three weeks after treatment in 72,4% of patients no clinical symptoms as well as normalization of immune status indices and decrease of specific antibodies titers were observed. Sixty nine patients reported improvement of subjective health status, however they had high level of specific antibodies. Immunological examination of these patients after second course of immunomodulatory therapy confirmed their convalescence. It was shown that the condition of immune status determines effect of the different immunomodulators.

About the authors

A. P. Toptygina

ФБУН Московский НИИ эпидемиологии и микробиологии им. Г.Н. Габричевского, Москва

Author for correspondence.

к.м.н., ведущий научный сотрудник лаборатории цитокинов

125212, Москва, ул. Адмирала Макарова, 10

Russian Federation

G. V. Bobyleva

ФБУН Московский НИИ эпидемиологии и микробиологии им. Г.Н. Габричевского, Москва

Russian Federation

V. A. Alioshkin

ФБУН Московский НИИ эпидемиологии и микробиологии им. Г.Н. Габричевского, Москва

Russian Federation


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Copyright (c) 2014 Toptygina A.P., Bobyleva G.V., Alioshkin V.A.

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