Chemokine receptor expression on peripheral blood T-helper cells in Helicobacter pylori-associated diseases: chronic gastroduodenitis and peptic ulcer disease

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Abstract

Helicobacter pylori represents a pathogen causing chronic infection in around a half of the global human population, which manifestations vary from asymptomatic infection to developing gastritis and peptic ulcer. The data accumulated suggest that overt clinical types of this infection are associated with lost immunoregulation and increased pro-inflammatory cell-mediated immune response triggered by H. pylori-specific T helper cells. Here, we examined the degree of peripheral blood CD4+ T cell maturity and related expression of chemokine receptors involved in migration to gastrointestinal tract (CCR9 and CCR6), as well as Тand B-cell zones of lymphoid organs (CCR7 and CXCR5). It was shown that overt H. pylori-infection was coupled to changes in expression pattern of chemokine receptors on T helper cells. In particular, percentage of mature CD4+CD45RO+ T cells bearing CCR9 and immature CD4+CD45RO– Т cells expressing CXCR5 was increased in peripheral blood of patients with chronic gastroduodenitis. However, increased amount of activated mature CD4+CD45RO+ICOS+ T cells was observed in patients with chronic gastroduodenitis comorbid with peptic ulcer that was also associated with elevated amount of mature CCR6+ T helpers (mainly CD4+CD45RO+CCR7– CCR6+ cells) and follicular T helper cells as well as emerging minor CD4+CD45RO+CXCR5+CCR6+.T cell subset, not affecting CD4+CCR9+ Т cells. Thus, the data obtained evidence that tissue-specific T-helper cell migration is controlled separately in of H. pylori-associated diseases. 

About the authors

V. Yu. Talayev

I.N. Blokhina Nizhny Novgorod Scientific and Research Institute of Epidemiology and Microbiology

Author for correspondence.
Email: talaev@inbox.ru

PhD, MD (Medicine), Professor, Head of the Laboratory of Cellular Immunology 

Contacts: Vladimir Yu. Talayev 603950, Russian Federation, Nizhny Novgorod, Malaya Yamskaya str., 71, I.N. Blokhina Nizhny Novgorod Research Institute of Epidemiology and Microbiology. Phone: +7 (831) 469-79-48

Russian Federation

M. V. Talaeyva

I.N. Blokhina Nizhny Novgorod Scientific and Research Institute of Epidemiology and Microbiology

Email: marya.talaeva@yandex.ru
PhD (Biology), Senior Researcher, Laboratory of Cellular Immunology Russian Federation

E. V. Voronina

I.N. Blokhina Nizhny Novgorod Scientific and Research Institute of Epidemiology and Microbiology

Email: el2v@mail.ru
Junior Researcher, Laboratory of Cellular Immunology Russian Federation

I. Ye. Zaichenko

I.N. Blokhina Nizhny Novgorod Scientific and Research Institute of Epidemiology and Microbiology

Email: imm.irina@mail.ru
PhD (Biology), Leading Researcher, Laboratory of Cellular Immunology Russian Federation

N. V. Neumoina

I.N. Blokhina Nizhny Novgorod Scientific and Research Institute of Epidemiology and Microbiology

Email: tak1510@yandex.ru
PhD (Medicine), Head Physician, Infectious Diseases Clinic Russian Federation

K. M. Perfilova

I.N. Blokhina Nizhny Novgorod Scientific and Research Institute of Epidemiology and Microbiology

Email: tak1510@yandex.ru
PhD (Medicine), Deputy Head Physician, Infectious Diseases Clinic Russian Federation

O. N. Babaykina

I.N. Blokhina Nizhny Novgorod Scientific and Research Institute of Epidemiology and Microbiology

Email: olga_babaykina@inbox.ru
PhD (Medicine), Senior Researcher, Laboratory of Cellular Immunology Russian Federation

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Copyright (c) 2019 Talayev V.Y., Talaeyva M.V., Voronina E.V., Zaichenko I.Y., Neumoina N.V., Perfilova K.M., Babaykina O.N.

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