Email this article RELATIONSHIP BETWEEN THE INNATE AND ADAPTIVE IMMUNITY IN INFECTIONS (REVISION OF CLASSIC DOGMA)
- Authors: Freidlin I.S.1
-
Affiliations:
- НИИ экспериментальной медицины СЗО РАМН, Санкт-Петербург
- Issue: Vol 1, No 3 (2011)
- Pages: 199-206
- Section: LECTURES
- Submitted: 30.06.2014
- Accepted: 30.06.2014
- Published: 30.06.2014
- URL: https://iimmun.ru/iimm/article/view/47
- DOI: https://doi.org/10.15789/2220-7619-2011-3-199-206
- ID: 47
Cite item
Full Text
Abstract
Abstract. The mechanisms of the immune system responding to an infection depend on a complex interrelation between the elements of innate and adaptive immunity. The current understanding of how signaling from innate immunity receptors shapes the adaptive immune response against pathogens and how it looks like the adaptive control of innate immunity are discussed in the article. One of the main problem needed to be highlighted is if adaptive immune cells suppress or activate innate immunity? Several studies yield new light to the question how the adaptive immunity can compensate, suppress and activate innate immunity. The role of inflammatory signals of dendritic cells activation in induction and modulation of adaptive immunity is described. Innate immunity receptors instruct the adaptive immune system on when and how to best respond to a concrete infection.
Keywords
About the authors
I. S. Freidlin
НИИ экспериментальной медицины СЗО РАМН, Санкт-Петербург
Author for correspondence.
Email: irinaf-n@yandex.ru
член-корреспондент РАМН, профессор, руководитель отдела иммунологии
197376, Санкт-Петербург, ул. Акад. Павлова, 12
РоссияReferences
- Ярилин А.А. Иммунология: учебник. — М.: ГЭОТАР-Медиа, 2010. — 752 с.
- Joffre O., Nolte M., Sporri R., Reis e Sousa C. Inflammatory signals in dendritic cell activation and induction of adaptive immunity // Immun. Rev. — 2009. — Vol. 227. — P. 234–247.
- Manicassamy S., Pulendran B. Modulation of adaptive immunity with Toll-like receptors // Semin. Immunol. — 2009. — Vol. 21. — P. 185–193.
- McFall-Ngai M. Care for the community // Nature. — 2007. — Vol. 445, N 7124. — P. 153.
- Palm N., Medzhitov R. Pattern recognition receptors and control of adaptive immunity // Immun. Rev. — 2009. — Vol. 227. — P. 221–233.
- Paust S., Gill H., Wang B., Flynn M., Moseman E., Senman B., Szczepanik M., Telenti A., Askenase Ph., Compans R., Andrian U. von. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses // Nat. Immun. — 2010. — Vol. 11. — P. 1127–1135.
- Shanker A. Adaptive control of innate immunity // Immunol. lett. — 2010. — Vol. 131. — P. 107–112.
- Trinchieri G., Sher A. Cooperation of Toll-like receptor signals in innate immune defence // Immunol. — 2007. — Vol. 7. — P. 179–190.
- Wood P. Understanding immunology / 2nd ed. — United Kingdom: Pearson Education Ltd, 2006. — 300 p.
- Zhao J., Yang X., Auh S., Kim K., Tang H., Fu Y. Do adaptive immune cells suppress or activate innate immunity? // Trends Immunol. — 2008. — Vol. 30, N 1. — P. 8–12.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).