THE BIOTIC FACTOR OF TREMATOD OPISTHORHIS FELINEUS INVASION INFLUENCE ON HOST IMMUNE STATUS AND SOMATIC CELLS PROLIFERATIVE ACTIVITY

Cover Page


Cite item

Full Text

Abstract

The paper confirms long-time opisthorhis invasion role as a risk factor of host immune system reconstitution as well as an important factor in holangiocarcinomas development. It was shown that opisthorhosis invasion primal stage induce host immune system reconstitution. Host immune B-cells system is activated by metacercaria antigens, while the same antigens inhibits T-cells activity. Opisthorhis metabolites stimulate proliferative mithogen-induced T-cells acti vity. Chronic opisthorchis invasion leads to immune system disbalance. It means: decrease of specific and non-speci fic natural killers activity, number of high proliferative activity T-lymphocytes and the shift of regulatory T-cells subset to suppressors prevalence. At the same time specific as well as non-specific T-suppressors functional ability is very low. It was shown T-cells helper-amplifier activation. Despite of circulating B-cells decrease the antibody produced cells number is spleen increases significantly at the same time with circulating immune complexes accumulation. Even 3–6 month after dehelmintisation the immune system disbalance decreases but lefts. In addition, chronic opisthorhis invasion leads to the proliferative processes activation in ductal epithelium, liver, lymph nodes and in other organs which leads to cancer proliferation. According to the results obtained the opisthorhis infected patients needs to be immunocorrected before as well as after dehelmintisation for holangiocancerogenesis profylaxis.

About the authors

A. G. Rybka

Tyumen State University, Tyumen, Russian Federation

Author for correspondence.
Email: fond.quality.life@rambler.ru

PhD (Biology), Senior Researcher, Associate Professor, Department of Physical Geography and Ecology, Institute of Earth Sciences, Tyumen State University, Tyumen, Russian Federation.

Россия

References

  1. Адо А.Д. Общая аллергология: руководство для врачей. М.: Медицина, 1978. 464 с. [Ado A.D. Obshchaya allergologiya: rukovodstvo dlya vrachei [General allergology: a guide for physicians]. Moscow: Medicine, 1978, 464 p.]
  2. Белозеров Е.С., Шувалова Е.П. Описторхоз. М.: Медицина, 1981. 128 с. [Belozerov E.S., Shuvalova E.P. Opistorkhoz [Opisthorchiasis]. Moscow: Medicine, 1981, 128 p.]
  3. Бернет Ф. Клеточная иммунология. М.: Мир, 1971. 542 с. [Burnet F. Kletochnaya immunologiya [Cellular immunology]. Moscow: Mir, 1971, 542 p.]
  4. Гиновкер И.А. Иммуноморфологические и цитохимические изменения лимфоидных органов при экспериментальном описторхозе // Медицинская паразитология и паразитарные болезни. 1971. № 6. С. 657–663. [Ginovker I.A. Immunomorphological and cytochemical changes of lymphoid organs in experimental opisthorchiasis. Meditsinskaya parazitologiya i parazitarnye bolezni = Medical Parasitology and Parasitic Diseases, 1971, no. 6, рp. 657–663. (In Russ.)]
  5. Глумов В.Я., Урошников А.С., Чураков А.Н. Морфогенез и патогенез поражений внутрипеченочных сосудов в острой и хронической стадиях экспериментального описторхоза // Медицинская паразитология и паразитарные болезни. 1986. № 5. С. 24–29. [Glumov V.Ya., Uroshnikov A.S., Churakov A.N. The morphogenesis and pathogenesis of the intrahepatic vascular lesions in acute and chronic stages of experimental opisthorchiasis. Meditsinskaya parazitologiya i parazitarnye bolezni = Medical Parasitology and Parasitic Diseases, 1986, no. 5, pp. 24–29. (In Russ.)]
  6. Жуков Н.А., Климова С.К. Аллергический дегельминтизационный синдром при описторхозе // Терапевтический архив. 1993. № 11. С. 49–53. [Zhukov N.A., Klimova S.K. Allergic degelmintization syndrome in opisthorchiasis. Terapevticheskii arkhiv = Therapeutic archive, 1993, no. 11, pp. 49–53 (In Russ.)]
  7. Жулай Г.А., Олейник Е.К. Регуляторные Т-клетки и канцерогенез // Иммунология. 2013. Т. 34, № 1. С. 61–64. [July G.A., Oleinik E.K. Regulatory T-cells and carcinogenesis. Immunologiya = Immunology, 2013, vol. 34, no. 1. pp. 61–64. (In Russ.)]
  8. Зубов Н.А., Муканов В.Н. Паразитарные гранулемы в стенке желчных протоков при экспериментальном описторхозе // Медицинская паразитология и паразитарные болезни. 1976. Т. 45, № 3. С. 352–355. [Zubov N.A. Mukanov V.N. Parasitic granulomas in the wall of bile ducts in experimental opisthorchiasis. Meditsinskaya parazitologiya i parazitarnye bolezni = Medical Parasitology and Parasitic Diseases, 1976, vol. 45, nо. 3, pp. 352–355. (In Russ.)]
  9. Львова М.Н., Дужак Т.Г., Центалович Ю.П., Катохин А.В., Мордвинов В.А. Секретом мариты печеночного сосальщика Opisthorchis felineus // Паразитология. 2014. Т. 48, вып. 3. С. 169–184. [Lvova M.N., Duzhak T.G., Centalovih Y.P., Katohin A.V., Mordvinov V.A. Secretome of the adult liver fluke Opisthorchis felineus. Parazitologiya = Parasitology, 2014, vol. 48, no. 3, pp. 169–184. (In Russ.)]
  10. Малайцев В.В., Богданова И.М. Индуцируемая опухолевыми клетками активация системы врожденного иммунитета в популяции клеток селезенки интактных мышей in vitro // Иммунология. 2014. Т. 35, № 5. С. 247–250. [Malaycev V.V., Bogdanova I.M. Induced by tumor cells activation of the innate immune system in the population of spleen cells of intact mice in vitro. Immunologiya = Immunology, 2014, vol. 35, no. 5, pp. 247–250. (In Russ.)]
  11. Озерецковская Н.Н. Органная патология в острой стадии тканевых гельминтозов // Медицинская паразитология и паразитарные болезни. 2000. № 3. С. 3–7. [Ozeretskovskaya N.N. Organ pathology in the acute stage of tissue helminths. Meditsinskaya parazitologiya i parazitarnye bolezni = Medical Parasitology and Parasitic Diseases, 2000, no. 3, pp. 3–7 (In Russ.)]
  12. Харченко Е.П. Канцерогенез: иммунная система и иммунотерапия // Иммунология. 2011. Т. 32, № 1. С. 50–56. [Kharchenko E.P. Carcinogenesis: immune system and immunotherapy. Immunologiya = Immunology, 2011, vol. 32, no. 1, рp. 50–56. (In Russ.)]
  13. Шайн А.А., Шаназаров Н.А., Бабинов Б.Н., Федоров Н.М., Левина Е.С., Сабиров А.Х., Синяков А.Г., Шунько Е.Л., Кондратьев Н.П. Кафедра онкологии Тюменского ГМА. Сорок лет научно-исследовательской и педагогической работы // Тюменский медицинский журнал. 2010. № 2. С. 8–14. [Shayn A.A., Shanazarov N.A., Babinov B.N., Fedorov N.M., Levina E.S., Sabirov A.H., Sinyakov A.G., Shun’ko E.L., Kondratyev N.P. Department of Oncology in Tyumen State Medical Academy. Forty years of research and educational experience. Tyumenskii meditsinskii zhurnal = Tyumen Medical Journal, 2010, no. 2, рр. 8–14. (In Russ.)]
  14. Maruyama T., KonoK., Mizukami Y. Distribution of Th17 cells and FoxP3(+) regulatory T-cells in tumor-infiltrating lymphocytes, tumor-draining lymph nodes and peripheral blood lymphocytes in patients with gastric cancer. Cancer Sci., 2010, vol. 101, рр. 1947–1954. doi: 10.1111/j.1349-7006.2010.01624.x
  15. Yang Z.Z., Ansell S.M. The role of Treg cells in the cancer immunological response. Am. J. Immunol., 2009, vol. 5, no. 1, рр. 17– 28. doi: 10.4110/in.2009.9.6.209

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2016 Rybka A.G.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 64788 от 02.02.2016.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies