GENOTYPES OF EXTENSIVELY DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS STRAINS: CLINICAL AND EPIDEMIOLOGICAL FEATURES OF PULMONARY TUBERCULOSIS

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Abstract

Here, we present clinical and epidemiological analysis of 85 Russian cases of pulmonary tuberculosis caused by an extensively drug-resistant M. tuberculosis strains. As defined by spoligotyping, M. tuberculosis strains belonged to the following genetic families: Beijing — 81.2%, which significantly exceeds the prevalence rate of this genotype (50%) in M. tuberculosis population across Russia; LAM — 14.1% and Ural — 4.7%. Among patients infected with Beijing strains prevailed alcohol and tobacco abused males; the main source of infection were family and penitentiary contacts. This group of patients has been characterized by a variety of clinical forms of lung disease with the prevalence of fibro-cavernous tuberculosis and a significant proportion of patients with interrupted treatment. Regardless of the M. tuberculosis strain genotype, the extensively drug-resistant pulmonary tuberculosis is characterized by severe course leading to the chronic disease with the relapses and poor response to anti-tuberculosis treatment, requiring repeated hospitalizations and surgical treatments.

About the authors

N. R. Vasilieva

Research Institute of Phthisiopulmonology;
North-Western State Medical University named after I.I. Mechnikov

Author for correspondence.
Email: sagievanr@gmail.com

Epidemiologist;

PhD Candidate, Epidemiology, Parasitology and Disinfectology Department,

191036, Russian Federation, St. Petersburg, Ligovsky av., 2-4

Россия

A. A. Vyazovaya

St. Petersburg Pasteur Institute

Email: fake@neicon.ru

PhD (Biology), Senior Researcher, Laboratory of Molecular Microbiology,

St. Petersburg

Россия

V. Yu. Zhuravlev

Research Institute of Phthisiopulmonology

Email: fake@neicon.ru

Head of the Department of the Laboratory Diagnostics,

St. Petersburg

Россия

N. S. Solovieva

Research Institute of Phthisiopulmonology

Email: fake@neicon.ru

PhD (Medicine), Head of the Bacteriological Laboratory,

St. Petersburg

Россия

I. V. Mokrousov

St. Petersburg Pasteur Institute

Email: fake@neicon.ru

PhD, MD (Biology), Head of the Laboratory of Molecular Microbiology,

St. Petersburg

Россия

O. V. Narvskaya

Research Institute of Phthisiopulmonology;
St. Petersburg Pasteur Institute

Email: fake@neicon.ru

PhD, MD (Medicine), Leading Researcher, Laboratory of Molecular Microbiology,

St. Petersburg

Россия

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Copyright (c) 2016 Vasilieva N.R., Vyazovaya A.A., Zhuravlev V.Y., Solovieva N.S., Mokrousov I.V., Narvskaya O.V.

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