Email this article GENOTYPES OF EXTENSIVELY DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS STRAINS: CLINICAL AND EPIDEMIOLOGICAL FEATURES OF PULMONARY TUBERCULOSIS
- Authors: Vasilieva N.R.1,2, Vyazovaya A.A.3, Zhuravlev V.Y.1, Solovieva N.S.1, Mokrousov I.V.3, Narvskaya O.V.1,3
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Affiliations:
- Research Institute of Phthisiopulmonology
- North-Western State Medical University named after I.I. Mechnikov
- St. Petersburg Pasteur Institute
- Issue: Vol 6, No 2 (2016)
- Pages: 179-183
- Section: SHORT COMMUNICATIONS
- URL: https://iimmun.ru/iimm/article/view/404
- DOI: https://doi.org/10.15789/2220-7619-2016-2-179-183
- ID: 404
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Abstract
Here, we present clinical and epidemiological analysis of 85 Russian cases of pulmonary tuberculosis caused by an extensively drug-resistant M. tuberculosis strains. As defined by spoligotyping, M. tuberculosis strains belonged to the following genetic families: Beijing — 81.2%, which significantly exceeds the prevalence rate of this genotype (50%) in M. tuberculosis population across Russia; LAM — 14.1% and Ural — 4.7%. Among patients infected with Beijing strains prevailed alcohol and tobacco abused males; the main source of infection were family and penitentiary contacts. This group of patients has been characterized by a variety of clinical forms of lung disease with the prevalence of fibro-cavernous tuberculosis and a significant proportion of patients with interrupted treatment. Regardless of the M. tuberculosis strain genotype, the extensively drug-resistant pulmonary tuberculosis is characterized by severe course leading to the chronic disease with the relapses and poor response to anti-tuberculosis treatment, requiring repeated hospitalizations and surgical treatments.
About the authors
N. R. Vasilieva
Research Institute of Phthisiopulmonology;North-Western State Medical University named after I.I. Mechnikov
Author for correspondence.
Email: sagievanr@gmail.com
Epidemiologist;
PhD Candidate, Epidemiology, Parasitology and Disinfectology Department,
191036, Russian Federation, St. Petersburg, Ligovsky av., 2-4
Russian FederationA. A. Vyazovaya
St. Petersburg Pasteur Institute
Email: fake@neicon.ru
PhD (Biology), Senior Researcher, Laboratory of Molecular Microbiology,
St. Petersburg
Russian FederationV. Yu. Zhuravlev
Research Institute of Phthisiopulmonology
Email: fake@neicon.ru
Head of the Department of the Laboratory Diagnostics,
St. Petersburg
Russian FederationN. S. Solovieva
Research Institute of Phthisiopulmonology
Email: fake@neicon.ru
PhD (Medicine), Head of the Bacteriological Laboratory,
St. Petersburg
Russian FederationI. V. Mokrousov
St. Petersburg Pasteur Institute
Email: fake@neicon.ru
PhD, MD (Biology), Head of the Laboratory of Molecular Microbiology,
St. Petersburg
Russian FederationO. V. Narvskaya
Research Institute of Phthisiopulmonology;St. Petersburg Pasteur Institute
Email: fake@neicon.ru
PhD, MD (Medicine), Leading Researcher, Laboratory of Molecular Microbiology,
St. Petersburg
Russian FederationReferences
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).