INDICES OF IMMUNE RESPONSE IN PATIENTS OF FALCIPARUM MALARIA IN REPUBLIC OF GUINEA

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Abstract

Malaria in the Republic of Guinea is the main cause of morbidity and lethality. It takes the first place in number of all visits in medical service (30–40%) and is the main cause of hospital death. One records annually more than 8 millions malaria cases, and about 60 000 children deaths. Results of study of immune response changing on different disease phases in treatment of autochthon population and immune status of Europeans are presented. It was shown that immunity status (cellular and humoral) in population of Guinea (an endemic country on falciparum malaria) differs from one in Europeans living in tropics. During light forms of malaria one records an increase of T-lymphocyte and IgG number, whereas in grave cases one observed the acute decrease of these indices. The essential increase of B-lymphocyte number does not depends from gravity of disease and from malaria treatment. It was established that appearance of LSA1-41 antibodies was in a more degree in adult patients than in children. The positive correlation between IgM and IgG was established in adult patients as in children.

About the authors

M. Y. Boiro

Pasteur Institute of Guinea

Email: fake@neicon.ru

PhD (Biology), Professor, General Director,

Kindia

Гвинея

S. Boumbali

Pasteur Institute of Guinea

Email: fake@neicon.ru

PhD (Biology), Professor, Director of Doctor’s School,

Kindia

Гвинея

O. K. Konstantinov

Pasteur Institute of Guinea

Author for correspondence.
Email: olegkonst@mail.ru

PhD (Biology), Researcher,

Kindia, ВР146

Гвинея

S. Kalivogui

Pasteur Institute of Guinea

Email: fake@neicon.ru

PhD (Biology), Vice-Director,

Kindia

Гвинея

M. Koulibali

International Research Center of Tropical Infections

Email: fake@neicon.ru

PhD (Biology), Director,

Nzerekore

Гвинея

A. S. Bah

Pasteur Institute of Guinea

Email: fake@neicon.ru

Researcher,

Kindia

Гвинея

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Copyright (c) 2016 Boiro M.Y., Boumbali S., Konstantinov O.K., Kalivogui S., Koulibali M., Bah A.S.

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