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The peculiarities of clinical signs, immune and interferon status in 180 patients with laboratory confirmed infection of varying severity, caused by herpes simplex virus (VSHI) have been studied. It was determined that frequency of bacterial infections is increased in patients with more severe clinical forms of VSHI. In patients with mild course furunculosis was more often detected than in other groups. In patients with moderate course of VSHI vaginal candidiasis was more common. In patients with severe VSHI course the combination of labial and genital herpes as well as infection caused by the human papilloma virus were more prevalent. In case of severe infection occurred an increased frequency of dysbiosis, fatigue, low grade temperature, iron deficiency anemia and malignancies. The highest frequency of allergic reactions is observed in patients with moderate course of VSHI. The autoimmune syndrome manifestations were not depend on the severity of VSHI. The degree of reduction of cell immunity and disorders in the system of interferon were closely related to severity of VSHI course.

About the authors

T. M. Lyuboshenko

Omsk State Medical Academy, Russian Ministry of Health, Omsk, Russian Federation 644009, Russian Federation, Omsk, Maslennikova str., 150. Phone: +7 (3812) 36-36-83 (office)

Author for correspondence.

PhD (Medicine), Аssociate Professor, Аssociate Professor of Anatomy, Physiology, Sports Medicine and Hygiene Siberian State University of Physical Culture and Sports, Omsk, Russian Federation

Russian Federation

T. I. Dolgikh

Clinical Diagnostic Centre, Omsk, Russian Federation


PhD, MD (Medicine), Professor, Head of the Laboratory of Clinical Diagnostic Center, Omsk, Russian Federation

Russian Federation


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Copyright (c) 2015 Lyuboshenko T.M., Dolgikh T.I.

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