Email this article CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH HERPES INFECTIONS OF VARYING SEVERITY
- Authors: Lyuboshenko T.M.1, Dolgikh T.I.2
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Affiliations:
- Omsk State Medical Academy, Russian Ministry of Health, Omsk, Russian Federation 644009, Russian Federation, Omsk, Maslennikova str., 150. Phone: +7 (3812) 36-36-83 (office)
- Clinical Diagnostic Centre, Omsk, Russian Federation
- Issue: Vol 4, No 4 (2014)
- Pages: 359-364
- Section: ORIGINAL ARTICLES
- Submitted: 03.02.2015
- Accepted: 03.02.2015
- Published: 03.12.2014
- URL: https://iimmun.ru/iimm/article/view/247
- DOI: https://doi.org/10.15789/2220-7619-2014-4-359-364
- ID: 247
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Abstract
The peculiarities of clinical signs, immune and interferon status in 180 patients with laboratory confirmed infection of varying severity, caused by herpes simplex virus (VSHI) have been studied. It was determined that frequency of bacterial infections is increased in patients with more severe clinical forms of VSHI. In patients with mild course furunculosis was more often detected than in other groups. In patients with moderate course of VSHI vaginal candidiasis was more common. In patients with severe VSHI course the combination of labial and genital herpes as well as infection caused by the human papilloma virus were more prevalent. In case of severe infection occurred an increased frequency of dysbiosis, fatigue, low grade temperature, iron deficiency anemia and malignancies. The highest frequency of allergic reactions is observed in patients with moderate course of VSHI. The autoimmune syndrome manifestations were not depend on the severity of VSHI. The degree of reduction of cell immunity and disorders in the system of interferon were closely related to severity of VSHI course.
About the authors
T. M. Lyuboshenko
Omsk State Medical Academy, Russian Ministry of Health, Omsk, Russian Federation 644009, Russian Federation, Omsk, Maslennikova str., 150. Phone: +7 (3812) 36-36-83 (office)
Author for correspondence.
Email: luboshenkotm@mail.ru
PhD (Medicine), Аssociate Professor, Аssociate Professor of Anatomy, Physiology, Sports Medicine and Hygiene Siberian State University of Physical Culture and Sports, Omsk, Russian Federation
РоссияT. I. Dolgikh
Clinical Diagnostic Centre, Omsk, Russian Federation
Email: fake@neicon.ru
PhD, MD (Medicine), Professor, Head of the Laboratory of Clinical Diagnostic Center, Omsk, Russian Federation
РоссияReferences
- Булиева Н.Б. Эпидемиология оппортунистических инфекций при гемобластозах (обзор) 1. // Медицинский альманах. 2011. № 5 (18). С. 132–137. [Bulieva N.B. Epidemiology of opportunistic infections in hematological malignancies (review). Meditsinskii al’manakh = Medical Almanac, 2011, vol. 18, no. 5, pp. 132–137. (In Russ.)]
- Долгих Т.И., Соколова Т.Ф., Минакова Е.Ю. Изучение иммунофенотипа лимфоцитов у пациентов с микст-инфекцией, вызванной вирусами семейства Herpesviridae // Медицинская иммунология. 2010. Т. 12, № 4–5. С. 433–436. [Dolgikh T.I., Sokolova T.F., Minakova E.Yu. The immunophenotype of lymphocytes in patients with mixed infection caused by viruses of the family Herpesviridae. Meditsinskaya immunologiya = Medical Immunology, 2010, vol. 12, no. 4–5, pp. 433–436. (In Russ.)]
- Исаков В.А., Архипова Е.И., Исаков Д.В. Герпесвирусные инфекции человека: руководство для врачей. СПб.: СпецЛит, 2006. 303 с. [Isakov V.A., Arkhipov E.I., Isakov D.V. Herpesvirus infections in man: a guide for physicians. St. Petersburg: SpetsLit, 2006. 303 р.]
- Нагоев Б.С., Камбачокова З.А. Состояние клеточного иммунитета у больных герпесвирусными инфекциями // Вестник новых медицинских технологий. 2011. № 3 (18). С. 325–327. [Nagoev B.S., Kambachokova Z.A. State of cellular immunity in patients with herpes virus infection. Vestnik novykh meditsinskikh tekhnologii = Herald of New Medical Technologies, 2011, vol. 18, no. 3, pp. 325–327. (In Russ.)]
- Новикова И.А., Злотникова М.В. Субпопуляционный состав лимфоцитов у больных герпетической инфекцией тяжелого течения // Медицинская иммунология. 2010. Т. 12, № 4–5. С. 331–336. [Novikova I.A., Zlotnikova M.V. Subpopulations of lymphocytes in patients with herpes infection heavy flow. Meditsinskaya immunologiya = Medical Immunology, 2010, vol. 12, no. 4–5, pp. 331–336. (In Russ.)]
- Пронькина Н.С., Булыгин Г.В., Камзалакова Н.И., Тихонова Ю.С. Характеристика параметров иммунного статуса у больных хронической герпетической инфекцией с формированием синдрома хронической усталости и иммунной дисфункции // Фундаментальные исследования. 2013. № 5. С. 124–128. [Pronkina N.S., Buligin G.V., Kamzalakova N.I. Tikhonov Yu.S. Characteristic parameters of the immune status of patients with chronic herpes infection with the formation of chronic fatigue syndrome and immune dysfunction. Fundamental’nye issledovaniya = Fundamental Research, 2013, no. 5, pp. 124–128. (In Russ.)]
- Черевко Н.А., Попова И.С., Климов В.В. Особенности изменения популяционного иммунитета населения на фоне герпес-инфицирования // Российский аллергологический журнал. 2010. № 1 (1). С. 207–208. [Tcherevko N.A., Popov I.S., Klimov V.V. Features changing herd immunity of the population against the backdrop of a herpes infection. Rossiiskii allergologicheskii zhurnal = Russian Journal of Allergy, 2010, vol. 1, no. 1, pp. 207–208. (In Russ.)]
- Чигвинцева Е.А., Герасимова Н.М. Современные проблемы эпидемиологии, диагностики и лечения герпесвирусных заболеваний // Современные проблемы дерматовенерологии, иммунологии и врачебной косметологии. 2009. № 3. С. 89–94. [Chigvintseva E.A., Gerasimova N.M. Modern problems of epidemiology, diagnosis and treatment of herpesvirus diseases. Sovremennye problemy dermatovenerologii, immunologii i vrachebnoi kosmetologii = Modern Problems of Dermatology and Venereology, Immunology and Medical Cosmetology, 2009, no. 3, pp. 89–94. (In Russ.)]
- Jones C.A. Vertical transmission of genital herpes: prevention and treatment options. Drugs, 2009, vol. 69, no. 4, pp. 421–434.
- Ljungman P. Viral infections: current diagnosis and treatment. Hematology J., 2011, no. 5, pp. 63–68.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).