EPIDEMIOLOGY AND CLINICAL CHARACTERISTICS OF METAPNEUMOVIRUS INFECTION IN HOSPITALIZED CHILDREN IN NOVOSIBIRSK IN 2019-2024



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Abstract

Abstract

Introduction. Metapneumovirus frequently causes respiratory tract infections in children worldwide, with clinical manifestations ranging from mild upper respiratory tract disease to severe bronchiolitis and pneumonia. However, not all countries conduct regular metapneumovirus infection monitoring that complicates its infection trend analysis. The aim of the work was to analyze the etiological pattern of acute respiratory diseases by assessing proportion of metapneumovirus infection, as well as comparatively assess clinical characteristics of the main acute respiratory viral infections in children in Novosibirsk. Materials and Methods. Between November 2019 and May 2024, from children aged 0 - 17 years, admitted with symptoms of acute respiratory diseases there were collected and analyzed 6468 samples for metapneumovirus and other respiratory viruses using real-time polymerase chain reaction. Results. Viral etiology of acute respiratory diseases in hospitalized children was confirmed in 63.0% (4077/6468) of cases. The etiological ARVI pattern differed significantly in various epidemic seasons. Thus, in 2019 - 2020, influenza virus (27.8%) and respiratory syncytial virus (21.1%) dominated in the etiology of acute respiratory viral infections, while metapneumovirus was detected only in as few as 1.6% of children. In contrast, in 2020 - 2021, we observed a sharp increase in the detection rate of metapneumovirus (28%) paralleled with the absence of influenza virus and RSV. At the same time, in the following season (2021 - 2022) we did not detect any cases of metapneumovirus infection. In the following two seasons, the detection rate of metapneumovirus was about 5%: in children aged 3 - 6 years it was significantly higher than in infants and children aged 7 - 17 years. Clinical signs of metapneumovirus infection included fever, cough, dyspnoea, hypoxia and were similar to the manifestations of respiratory syncytial virus infection. At the same time, fever above 39°C and malaise were significantly more frequent in patients with influenza. Conclusion. Understanding the epidemiology of specific respiratory infections, compared with global trends, can help to develop targeted prevention and control measures.

About the authors

O. G. Kurskaya

Federal Research Center for Fundamental and Translational Medicine (FRC FTM), Novosibirsk, Russia

Email: kurskaya_og@mail.ru
ORCID iD: 0000-0002-1931-2026

M.Sc., Head of the Laboratory of Respiratory Viral Infections, S.Sc., Laboratory of Molecular Epidemiology and Virus Biodiversity

 

 

Россия, 630117, Novosibirsk, Timakov str., 2

Alina Nokhova

Federal Research Center for Fundamental and Translational Medicine (FRC FTM), Novosibirsk, Russia

Email: alina-nohova@mail.ru
ORCID iD: 0000-0002-7891-5847

Researcher at the Laboratory of Respiratory Viral Infections

Россия, 630117, г. Новосибирск, ул. Тимакова, 2

Tereza Saroyan

Federal Research Center for Fundamental and Translational Medicine (FRC FTM), Novosibirsk, Russia

Email: 111.st.13@rambler.ru
ORCID iD: 0000-0001-8071-5425

Researcher at the Laboratory of Respiratory Viral Infections

Россия

Maria V. Solomatina

Federal Research Center for Fundamental and Translational Medicine (FRC FTM), Novosibirsk, Russia

Email: mvsolomatina@frcftm.ru

senior researcher of the Laboratory of Molecular Epidemiology and Biodiversity of Viruses, PhD.

Eugenia A. Kazachkova

Federal Research Center for Fundamental and Translational Medicine (FRC FTM), Novosibirsk, Russia

Email: kazachkova.evgeniya@gmail.com

 Researcher of the Laboratory of Experimental Biology of Pathogenic Microorganisms.

Россия

Tatyana A. Gutova

Federal Research Center for Fundamental and Translational Medicine (FRC FTM), Novosibirsk, Russia

Email: theshirskiucot@gmail.com

laboratory assistant at the Laboratory of Respiratory Viral Infections.

Россия

Anjelika V. Anoshina

State Budgetary Healthcare Institution of NSO «Children's City Clinical Hospital No. 6»

Email: anzhelika.anoshina2010@yandex.ru

 Head of the Infectious Diseases Department GBUZ NSO «DGKB No. 6».

Россия

Olga A. Simkina

State Budgetary Healthcare Institution of NSO «Children's City Clinical Hospital No. 6»

Email: olgasimkina83@yandex.ru

 epidemiologist GBUZ NSO «DGKB No. 3».

Россия

K. A. Sharshov

Federal Research Center for Fundamental and Translational Medicine (FRC FTM), Novosibirsk, Russia

Email: sharshov@yandex.ru
ORCID iD: 0000-0002-3946-9872

Head of the Laboratory of Molecular Epidemiology and Biodiversity of Viruses, PhD.

Россия

A. M. Shestopalov

Federal Research Center for Fundamental and Translational Medicine (FRC FTM), Novosibirsk, Russia

Author for correspondence.
Email: shestopalov2@mail.ru

Director of the Research Institute of Virology, FIC MTF, Doctor of Biological Sciences, Professor

Россия, Novosibirsk

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Copyright (c) Kurskaya O.G., Nokhova A., Saroyan T., Solomatina M., Kazachkova E., Gutova T., Anoshina A., Simkina O., Sharshov K.A., Shestopalov A.M.

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