Email this article THE STATE OF HUMORAL IMMUNITY TO MEASLES, RUBELLA AND MUMPS IN HEALTHY PEOPLE AND PATIENTS WITH MEASLES
- Authors: Zherdeva P.E.1, Toptygina A.P.1,2, Nozdracheva A.V.3, Mamaeva T.A.1, Novikova L.I.1, Smerdova M.A.4, Iаrmolskaia M.S.5, Dementeva N.G.5, Gotvyanskay T.P.3, Semenenko A.V.3
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Affiliations:
- G.N.Gabrichevsky Research Institute for Epidemiology and Microbiology, Moscow, Russia
- Lomonosov Moscow State University
- Gamaleya National Research Center of Epidemiology and Microbiology, of the Ministry of Health of the Russian Federation
- JSC Vector-Best-Europe, Russia
- FGUZ Center for Hygiene and Epidemiology in Moscow
- Section: ORIGINAL ARTICLES
- Submitted: 15.03.2025
- Accepted: 08.06.2025
- URL: https://iimmun.ru/iimm/article/view/17893
- DOI: https://doi.org/10.15789/2220-7619-TSO-17893
- ID: 17893
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Abstract
Abstract
Measles, rubella and mumps are viral infections that can be prevented with highly effective vaccines. Recently, the incidence of measles and mumps has increased in many countries, involving highly immunized populations. The aim of the study was to assess measles, rubella and mumps humoral immunity in healthy people of different ages and compare these data with measles incidence in same area during the same time period. The serum samples from 713 conditionally healthy residents of different ages from Moscow and the Moscow region with an unknown vaccination history and from 700 patients with measles collected on the 4th-5th day after onset of rash were examined. Humoral immunity was determined by ELISA using the kits from AO Vector-Best, Russian Federation and Euroimmun, Germany. It was found that in the group of 1–5-year-old subjects, the seropositivity rate was below 60%. Seroprevalence in groups over 6-year-old subjects against rubella fluctuates at the level of 87-94%, mumps - 72-83%. The most unstable situation was observed in humoral immunity against measles virus. In the group of 6-13-year-old subjects, seroprevalence increased to 79% followed by decline to 49.5% in group of 18-30-year-old subjects. The subsequent increase in seropositivity to 88.12% in the group over 51-year-old subjects was significantly lower than the calculated population immunity level (95%). Among measles patients in 2024, children and adolescents accounted for 54.32%. Comparison of measles incidence with the measles seronegative level in the same age groups revealed a clear pattern: the more seronegative were subjects, the higher measles incidence was in this group. In a similar study on measles incidence in 2013, all children and adolescents responded to the infection with a primary immune response, and among adult patients, a secondary immune response was detected in 12-18%. In 2024, among children and adolescents with measles, 9-12% responded with a secondary immune response, and in adult groups, the proportion of secondary response reached 44%, indicating that individuals vaccinated in childhood but who lost measles antibodies during life actively contribute to measles cases. Vaccination of seronegative grades 10-11 adolescents is necessary.
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About the authors
Polina E. Zherdeva
G.N.Gabrichevsky Research Institute for Epidemiology and Microbiology, Moscow, Russia
Email: polya-zherdeva@mail.ru
SPIN-code: 1675-7056
Researcher of applied immunochemistry laboratory
Россия, 125212, Moscow, Admiral Makarov str., 10Anna P. Toptygina
G.N.Gabrichevsky Research Institute for Epidemiology and Microbiology, Moscow, Russia;Lomonosov Moscow State University
Email: toptyginaanna@rambler.ru
ORCID iD: 0000-0002-9981-4762
Scopus Author ID: 6602424818
ResearcherId: В-6725-2019
DSc (Medicine), Head Researcher, Head of the Laboratory of Cytokines, Professor, Department of Faculty of Biology
Россия, 125212, Moscow, Admiral Makarov str., 10; 119991 Moscow, Leninskiye Gory, 1Anna V. Nozdracheva
Gamaleya National Research Center of Epidemiology and Microbiology, of the Ministry of Health of the Russian Federation
Email: nozdracheva@gamaleya.org
SPIN-code: 3631-8083
PhD (Medicine), Head of Laboratory of nonspecific prophylaxis of infection diseases
Россия, 18, Gamaieya str. 123098 Moscow, RussiaTamara A. Mamaeva
G.N.Gabrichevsky Research Institute for Epidemiology and Microbiology, Moscow, Russia
Email: 4522826@bk.ru
SPIN-code: 2037-1553
PhD (Biology), Leading Research of applied immunochemistry laboratory
Россия, 125212, Moscow, Admiral Makarov str., 10Lidia I. Novikova
G.N.Gabrichevsky Research Institute for Epidemiology and Microbiology, Moscow, Russia
Email: novikovalida414@gmail.com
SPIN-code: 9507-7419
PhD (Medicine), Head of the Laboratory of immunobiological preparations
Россия, 125212, Moscow, Admiral Makarov str., 10Marina A. Smerdova
JSC Vector-Best-Europe, Russia
Email: biologsmerdova@yandex.ru
SPIN-code: 3070-7065
PhD (Biology), Leading Product Specialist
Россия, Moscow, Sosenskoye settlement, Nikolo-Khovanskoye village, house 1011BMaria S. Iаrmolskaia
FGUZ Center for Hygiene and Epidemiology in Moscow
Email: poliolab@yandex.ru
Head of the Virology Department of the Microbiological Laboratory
Россия, 129626, Moscow, Grafsky lane, 4 bldg. 2,3,4Natalia G. Dementeva
FGUZ Center for Hygiene and Epidemiology in Moscow
Email: poliolab@yandex.ru
Virologist, Department of Virology, Microbiological Laboratory
Россия, 129626, Moscow, Grafsky lane, 4 bldg. 2,3,4Tat'yana P. Gotvyanskay
Gamaleya National Research Center of Epidemiology and Microbiology, of the Ministry of Health of the Russian Federation
Email: gotvin@gamaleya.org
ORCID iD: 0000-0002-0814-2666
SPIN-code: 9288-2300
PhD (Biology), Senior Researcher, Laboratory of nonspecific prophylaxis of infection diseases, Department of Epidemiology
Россия, 18, Gamaieya str. 123098 Moscow, RussiaAnatoliy V. Semenenko
Gamaleya National Research Center of Epidemiology and Microbiology, of the Ministry of Health of the Russian Federation
Author for correspondence.
Email: centronix@gmail.com
SPIN-code: 2944-0376
PhD (Engineering), Senior Researcher, Laboratory of nonspecific prophylaxis of infection diseases, Department of Epidemiology
Россия, 18, Gamaieya str. 123098 Moscow, RussiaReferences
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