Results of implementation of viral hepatitis B elimination program in the North-West Russia

Cover Page


Cite item

Full Text

Abstract

Introduction. Vaccination contributed to reduce the incidence of acute hepatitis B in the territories of the North-West Russia. The urgency of this problem remains due to the high incidence of chronic hepatitis B. This accounted for the need to develop a hepatitis B elimination program in the district discussed that was approved in 2013 by the head of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing. Objective is to characterize the results of the program for the elimination of acute hepatitis B virus implemented in the North-Western Federal District. Materials and methods. The 2010–2020 incidence rate of acute and chronic hepatitis B virus (HBV) infection in the regions of the North-West Russia was carried out. To determine HBV genotypes and subgenotypes, 160 blood plasma samples from patients with acute hepatitis B were studied using molecular genetic methods (PCR, sequencing). The prevalence of latent hepatitis B in various population groups was assessed. The 2016–2020 hepatitis B vaccination coverage and relevant serological monitoring in adults was carried out. Results. While implementing the program, it was found that the incidence rate of acute hepatitis B in the district decreased by 4.5-fold, revealing in 2020 no cases of the disease in 5 regions, with incidence rate in the 6 subfederal units being lower than 1.0 per 100,000 population. Moreover, the incidence rate for chronic hepatitis B decreased by 2.6 times. The 2020 vaccination coverage of children under 17 and adults in all territories comprised more than 95% and 90%, respectively. In addition, it was shown the circulation of genotypes D and A of hepatitis B virus is dominated by genotype D (91.8%), subgenotype D2 (47.8%). The prevalence of latent hepatitis B among migrants was 6.5%, pregnant women — 4.9%, hemodialysis patients — 1.7%. Conclusion. Implementation of the program on elimination of acute viral hepatitis B in the territory of the North-West Russia contributed to raise in the vaccination coverage in adult population and lowered incidence rate of acute and chronic HBV infection.

About the authors

L. V. Lyalina

St. Petersburg Pasteur Institute; North-Western State Medical University named after I.I. Mechnikov

Author for correspondence.
Email: lyalinas@pasteurorg.ru
ORCID iD: 0000-0001-9921-3505

Lyudmila V. Lyalina,  PhD, MD (Medicine), Professor, Head of the Laboratory of Epidemiology of Infectious and Non-infectious Diseases; Professor of Department of Epidemiology, Parasitology and Desinfectology

197101, St. Petersburg, Mira str., 14

Phone: +7 921 584-63-85 (mobile) 

Россия

E. V. Esaulenko

St. Petersburg Pasteur Institute; St. Petersburg State Pediatric Medical University

Email: eve-gpmu@mail.ru
ORCID iD: 0000-0003-3669-1993

PhD, MD (Medicine), Professor, Head of the Viral Hepatitis Laboratory; Head of the Department of Adult Infectious Diseases and Epidemiology

St. Petersburg

Россия

E. V. Khorkova

Leningrad Regional Center for the Prevention and Control of AIDS and Infectious Diseases

Email: Khorkovae@yandex.ru
ORCID iD: 0000-0002-6550-1872

Head Physician Deputy 

St. Petersburg

Россия

K. E. Novak

St. Petersburg State Pediatric Medical University

Email: kseniya.novak@mail.ru
ORCID iD: 0000-0001-9633-4328

PhD (Medicine), Associate Professor, Department of Adult Infectious Diseases and Epidemiology 

St. Petersburg

Россия

Y. V. Ostankova

St. Petersburg Pasteur Institute

Email: shenna1@yandex.ru
ORCID iD: 0000-0003-2270-8897

PhD (Biology), Senior Researcher, Laboratory of Molecular Immunology 

St. Petersburg

Россия

E. N. Serikova

St. Petersburg Pasteur Institute

Email: elena.donetsk.serikova@mail.ru
ORCID iD: 0000-0002-0547-3945

Researcher, Laboratory of Virology and Immunology of HIV Infection 

St. Petersburg

Россия

D. V. Vasilyev

Polyclinic No. 48

Email: justgreen@mail.ru

Epidemiologist 

St. Petersburg

Россия

E. S. Gorziy

St. Petersburg Pasteur Institute; North-Western State Medical University named after I.I. Mechnikov

Email: egorziy@yandex.ru
ORCID iD: 0000-0003-4195-679X

Investigator, Laboratory of Epidemiology of Infectious and Non-infectious Diseases 

St. Petersburg

Россия

M. J. Butskaya

St. Petersburg Pasteur Institute; St. Petersburg State Pediatric Medical University

Email: butskaya.masha@yandex.ru

PhD Student, Department of Infectious Diseases of Adults and Epidemiology; Junior Researcher, Viral Hepatitis Laboratory 

St. Petersburg

Россия

I. V. Kritskaya

Rospotrebnadzor Office for St. Petersburg

Email: kritskaya.i.v@gmail.com
ORCID iD: 0000-0002-6103-7013

Deputy Head of the Epidemiological Surveillance Department 

St. Petersburg

Россия

L. V. Buts

Rospotrebnadzor Office for Leningrad Region

Email: lidabuts@mail.ru
ORCID iD: 0000-0002-2631-0256

Head of the Epidemiological Surveillance Department 

St. Petersburg

Россия

E. V. Grebenkina

Rospotrebnadzor Office for Novgorod Region

Email: homochk@mail.ru

Deputy Head of the Epidemiological Surveillance Department 

Velikiy Novgorod

Россия

E. V. Baydakova

Rospotrebnadzor Office for Arkhangelsk Region; Northern State Medical University of the Ministry of Health of Russian Federation

Email: elenabaydakova@yandex.ru

Chief Special Expert, Epidemiological Surveillance Department; Assistant Professor, Hygiene and Medicine Ecology Department 

Arkhangelsk

Россия

N. A. Smirnova

Rospotrebnadzor Office for Vologda Region

Email: sirnnik78@mail.ru

Deputy Head of the Epidemiological Surveillance Department 

Vologda

Россия

M. A. Krasnopyorova

Rospotrebnadzor Office for Kaliningrad Region

Email: epidotdel@39.rospotrebnadzor.ru

Chief Special Expert, Department of Epidemiological Surveillance and Sanitary Protection 

Kaliningrad

Россия

N. S. Koltsov

Rospotrebnadzor Office for Murmansk Region

Email: kolcov_ns@murmanpotrebnadzor.ru

Head of the Epidemiological Surveillance Department 

Murmansk

Россия

L. M. Kotovich

Rospotrebnadzor Office for the Republic of Karelia

Email: glavepid@yandex.ru

Acting Head  

Petrozavodsk

Россия

E. L. Kalinina

Rospotrebnadzor Office for Pskov Region

Email: epid@60.rospotrebnadzor.ru

Head of the Epidemiological Surveillance Department 

Pskov

Россия

R. R. Galimov

Rospotrebnadzor Office for Komi Republic

Email: galimov@gsenkomi.ru

Head of the Epidemiological Surveillance Department 

Syktyvkar

Россия

N. V. Kirkhar

Rospotrebnadzor Office for Nenets Autonomous Okrug

Email: turpnnao@mail.ru

Head 

Naryan-Mar

Россия

E. A. Cherepanova

Federal Center of Hygiene and Epidemiology

Email: cherepanovaea@fcgic.ru

Deputy Head of the Epidemiological Surveillance Department 

Moscow

Россия

Areg A. Totolian

St. Petersburg Pasteur Institute

Email: totolian@spbraaci.ru
ORCID iD: 0000-0003-4571-8799

RAS Full Member, PhD, MD (Medicine), Professor, Head of the Laboratory of Molecular Immunology; Director 

St. Petersburg

Россия

References

  1. Азовцева О.В., Пантелеев А.М., Карпов А.В., Архипов Г.С., Вебер В.Р., Беляков Н.А., Архипова Е.И. Анализ медикосоциальных факторов, влияющих на формирование и течение коинфекции ВИЧ, туберкулеза и вирусного гепатита // Инфекция и иммунитет. 2019. Т. 9, № 5–6. С. 787–799. [Azovtseva O.V., Panteleev A.M., Karpov A.V., Arkhipov G.S., Weber V.R., Belyakov N.A., Arkhipova E.I. Analysis of medical and social factors affecting the formation and course of co-infection HIV, tuberculosis and viral hepatitis. Infektsiya i immunitet = Russian Journal of Infection and Immunity, 2019, vol. 9, no. 5–6, pp. 787–799. (In Russ.)] doi: 10.15789/2220-7619-2019-5-6-787-799
  2. Акимкин В.Г., Семененко Т.А. Эпидемиологическая и иммунологическая эффективность вакцинации медицинских работников против гепатита В // Эпидемиология и вакцинопрофилактика. 2017. Т. 16, № 4. С. 52–57. [Akimkin V.G., Semenenko T.A. epidemiological and immunological efficacy of health workers vaccination against Hepatitis B. Epidemiologiya i vaktsinoprofilaktika = Epidemiology and Vaccinal Prevention, 2017, vol. 16, no. 4, pр. 52–57. (In Russ.)] doi: 10.31631/2073-3046-2017-16-4-52-57
  3. ВОЗ. Глобальная стратегия сектора здравоохранения по вирусному гепатиту на 2016–2021 гг.: на пути к ликвидации вирусного гепатита. Женева: ВОЗ, 2016. 56 с. [WHO. Global health sector strategy on viral hepatitis 2016–2021: towards ending viral hepatitis. Geneva: WHO, 2016. 56 p. (In Russ.)]
  4. Гасич Е.Л., Еремин В.Ф., Немира А.С. Молекулярная эпидемиология генотипов вируса гепатита В, изолированных в Республике Беларусь // ВИЧ-инфекция и иммуносупрессия. 2016. Т. 8, № 4. С. 43–54. [Gasich E.L., Eremin V.F., Nemira A.S. Molecular epidemiology of hepatitis B virus genotypes isolated in Belarus. VICh-infektsiya i immunosupressia = HIVinfection and Immunosupression, 2016, vol. 8, no. 4, pp. 43–54. (In Russ.)] doi: 10.22328/2077-9828-2016-8-4-43-54
  5. Елпаева Е.А., Порецкова Е.А., Писарева М.А., Ковеленов А.Ю., Аликян И.С., Гальбрайх Р.Б., Грудинин М.П., Эсауленко Е.В. Генотипическая характеристика вируса гепатита В у хронически инфицированных больных // Дальневосточный журнал инфекционной патологии. 2009. Т. 15, № 15. С. 55–58. [Elpaeva E.A., Poretskova E.A., Pisareva M.A., Kovelenov A.Yu., Alikyan A.U., Galbreikh R.B., Grudinin M.P., Yesaulenko E.V. Genotypic characteristics of hepatitis B virus in chronically infected patients. Dal’nevostochnyy zhurnal infektsionnoy patologii = Far Eastern Journal of Infectious Pathology, 2009, vol. 15, no. 15, pp. 55–58. (In Russ.)]
  6. Жебрун А.Б., Мукомолов С.Л., Лялина Л.В., Тотолян А.А. Программа элиминации острого вирусного гепатита В на территории Северо-Западного федерального округа Российской Федерации. СПб.: ФБУН НИИЭМ имени Пастера, 2016. 20 с. [Zhebrun A.B., Mukomolov S.L., Lyalina L.V., Totolian A.A. Program for the elimination of acute viral hepatitis in the Northwestern Federal District of the Russian Federation. St. Petersburg Pasteur Institute, 2016. 20 p. (In Russ.)]
  7. Михайлов М.И., Кюрегян К.К., Малинникова Е.Ю., Исаева О.В., Карлсен А.А., Потемкин И.А., Кичатова В.С., Аль-Шараби Шукри А.С., Догадов Д.И., Корзая Л.И., Игнатьева М.Е., Поляков А.Д. Вирусные гепатиты: прогнозы и проблемы // Эпидемиология и инфекционные болезни. Актуальные вопросы. 2019. Т. 9, № 1. С. 71–80. [Mikhailov M.I., Kyuregyan K.K., Malinnikova E.Yu., Isaeva O.V., Karlsen A.A., Potemkin I.A., Kichatova V.S., Al-Sharabi Shukri A.S., Dogadov D.I., Korzaya L.I., Ignat’eva M.E., Poliakov A.D. Viral hepatitis: prognosis and problems. Epidemiologia i infektsionnye bolezni. Aktual’nye voprosy = Epidemiology and Infectious Diseases. Current Issues, 2019, vol. 9, no. 1, pp. 71–80. (In Russ.)]
  8. Нечаев В.В., Иванов А.К., Сакра А.А., Романова Е.С., Лялина Л.В., Пожидаева Л.Н. Хронические вирусные гепатиты, туберкулез и ВИЧ-инфекция как сочетанные заболевания: от теории к практике // Журнал инфектологии. 2017. Т. 9, № 4. С. 126–132. [Nechaev V.V., Ivanov A.K., Sakra A.A., Romanova E.S., Lyalina L.V., Pozhidaeva L.N. Chronic viral hepatitis, tuberculosis and HIV infection as co-infections: from theory to practice. Zhurnal infektologii = Journal Infectology, 2017, vol. 9, no. 4, pp. 126–132. (In Russ.)] doi: 10.22625/2072-6732-2017-9-4-126-132
  9. Останкова Ю.В., Семенов А.В., Зуева Е.Б., Тотолян Арег А. Выявление и молекулярно-генетическая характеристика вируса гепатита В среди ВИЧ-инфицированных пациентов в Архангельске // Вопросы вирусологии. 2019. Т. 64, № 3. С. 105–111. [Ostankova Yu.V, Semenov A.V., Zueva E.B., Totolian Areg A. Identification and molecular-genetic characteristics of the hepatitis B virus among HIV-infected patients in Arkhangelsk. Voprosy virusologii = Problems of Virology, 2019, vol. 64, no. 3, pp. 105–111. (In Russ.)] doi: 10.18821/0507-4088-2019-64-3-105-111
  10. Останкова Ю.В., Семенов А.В., Тотолян Арег А. Выявление вируса гепатита В в плазме крови при низкой вирусной нагрузке // Клиническая лабораторная диагностика. 2019. Т. 64, № 10. С. 635–640. [Ostankova Yu.V., Semenov A.V., Totolian Areg A. Detection of hepatitis B virus in blood plasma at low viral load. Klinicheskaya laboratornaya diagnostika = Russian Clinical Laboratory Diagnostics, 2019, vol. 64, no. 10, pp. 635–640. (In Russ.)] doi: 10.18821/0869-2084-2019-64-10-635-640
  11. Шулакова Н.И., Лыткина И.Н., Акимкин В.Г., Ершова О.Н., Шахгильдян И.В., Кистенева Л.Б., Кузина Л.Е., Чернявская О.П. Иммунологическая эффективность массовой вакцинопрофилактики против гепатита В в рамках реализации приоритетного Национального проекта “Здоровье” в отдельных регионах Российской Федерации // Эпидемиология и инфекционные болезни. 2015. Т. 20, № 4. C. 4–7. [Shulakova N.I., Lytkina I.N., Akimkin V.G., Ershova O.N., Shahgildyan I.V., Kisteneva L.B., Kuzina L.E., Chernyavskaya O.P. Immunological effectiveness of mass vaccine prophylaxis against hepatitis B within the framework of the National Priority Project “Health” in some regions of the Russian Federation. Epidemiologiya i infektsionnye bolezni = Epidemiology and Infectious Diseases, 2015, vol. 20, no. 4, pp. 4–7. (In Russ.)] doi: 10.17816/EID40845
  12. Эсауленко Е.В., Цинзерлинг В.А., Карев В.Е., Шибаева Е.О. Оккультный хронический гепатит В: клинико-морфологические сопоставления // Вестник Новгородского государственного университета. 2016. Т. 97, № 6. С. 80–84. [Esaulenko E.V., Zinserling V.A., Karev V.E., Shibaeva E.O. Occult chronic hepatitis B: clinical and morphological comparisons. Vestnik Novgorodskogo gosudarstvennogo universiteta = Herald of Novgorod State University, 2016, vol. 97, no. 6, pp. 80–84. (In Russ.)]
  13. Baclig M.O., Reyes K.G., Liles V.R., Gopez-Cervantes J. Association of hepatitis B genotypes with clinical profile of patients with chronic hepatitis B. Int. J. Mol. Epidemiol. Genet., 2020, vol. 11, no. 2, pp. 26–30.
  14. Hu J., Cheng J., Tang L., Hu Z., Luo Y., Li Y., Zhou T., Chang J., Guo J.T. Virological basis for the cure of chronic Hepatitis B. ACS Infect. Dis., 2019, vol. 5, no. 5, pp. 659–674. doi: 10.1021/acsinfecdis.8b00081
  15. Jefferies M., Rauff B., Rashid H., Lam T., Rafiq S. Update on global epidemiology of viral hepatitis and preventive strategies. World J. Clin. Cases, 2018, vol. 6, no. 3, pp. 589–599. doi: 10.12998/wjcc.v6.i13.589
  16. Nayagam S., Thursz M., Sicuri E., Conteh L., Wiktor S., Low-Beer D., Hallett T. Requirements for global elimination of hepatitis B: a modelling study. Lancet Infect. Dis., 2016, vol. 16, no. 12, pp. 1399–1408. doi: 10.1016/S1473-3099(16)30204-3
  17. Nelson N.P., Easterbrook P.J., McMahon B.J. Epidemiology of hepatitis B virus infection and impact of vaccination on disease. Clin. Liver Dis., 2016, vol. 20, no. 4, pp. 607–628. doi: 10.1016/j.cld.2016.06.006
  18. Ringelhan M., McKeating J.A., Protzer U. Viral hepatitis and liver cancer. Philos Trans. R. Soc. Lond. B Biol. Sci., 2017, vol. 372, no. 1732: 20160274. doi: 10.1098/rstb.2016.0274
  19. Seto W.K., Lo Y.R., Pawlotsky J.M., Yuen M.F. Chronic hepatitis B virus infection. Lancet, 2018, vol. 392, no. 10161, pp. 2313– 2324. doi: 10.1016/S0140-6736(18)31865-8
  20. Wang H., Tian C.W., Wang W.M., Luo X.M. Time-series analysis of tuberculosis from 2005 to 2017 in China. Epidemiol. Infect., 2018, vol. 146, no. 8, pp. 935–939. doi: 10.1017/S0950268818001115

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2021 Lyalina L.V., Esaulenko E.V., Khorkova E.V., Novak K.E., Ostankova Y.V., Serikova E.N., Vasilyev D.V., Gorziy E.S., Butskaya M.J., Kritskaya I.V., Buts L.V., Grebenkina E.V., Baydakova E.V., Smirnova N.A., Krasnopyorova M.A., Koltsov N.S., Kotovich L.M., Kalinina E.L., Galimov R.R., Kirkhar N.V., Cherepanova E.A., Totolian A.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 64788 от 02.02.2016.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies