THE INCIDENCE OF BK VIRUS INFECTION IN PATIENTS WITH DYSFUNCTION OF KIDNEY TRANSPLANT



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Abstract

BK virus-induced nephropathy is an important cause of renal dysfunction, leading to the loss of transplanted kidneys in up to 50% of cases. This study aimed to appraise the incidence of BKV infection among patients who have received kidney transplantation in Iran.

 In this retrospective cross-sectional study, recipients of kidney transplants in Mashhad Montaserieh Hospital with a rise of 25% or higher in serum creatinine after at least one month of transplantation were evaluated. Those with evidence of BKV infection, including positive serum or urine polymerase chain reaction (PCR) were included.

 Overall, of 471 patients, 135 cases (28.7%) were diagnosed with kidney transplant dysfunction. BKV infection was diagnosed based on positive PCR in 30 patients (22.2%) and BKV nephropathy was present in 11 patients (8.1%). The most common cause of ESRD (End Stage Renal Disease) was hypertension (33.3%) and the most common dialysis method was hemodialysis (90%). 10 patients had hematuria or pyuria. In 11 patients with pathological results, the most common finding was interstitial inflammation with tubular cytopathic changes (4 patients, 36.4%). Blood levels of cyclosporine were significantly correlated with the time from transplantation to diagnosis, and tacrolimus level was significantly correlated with creatinine level at diagnosis (P<0.05). Positive U/A was significantly associated with the time from transplantation to the diagnosis of kidney dysfunction in the regression analysis (95%CI: -0.30 to -23.45,P = 0.045).

The most important predictor of the occurrence of this disorder in kidney transplant patients was the presence of hematuria and pyuria in urine tests. Moreover,The frequency of BK infection was significantly higher in men than in women, while no significant difference was observed between men and women in the control group.

About the authors

K. Samadi

Sabzevar University of Medical Sciences, Sabzevar, Iran.

Email: jalambadaniz@mums.ac.ir

Assistant Professor of Nephrology, Department of Internal Medicine, Faculty of Medicine,

Иран

Azhdary Y. Moghaddam

Mashhad university of medical sciences, Mashhad Iran
Zahedan University of Medical Sciences, Zahedan, Iran

Email: jalambadaniz@medsab.ac.ir

Student Research committee, Faculty of Medicine; 

Faculty Member

Иран, Мешхедский университет медицинских наук, Мешхед, Иран. Захеданский университет медицинских наук, Захедан, Иран

Ab. a. Zeraati

Mashhad university of medical sciences, Mashhad Iran.

Email: jalambadaniz@yahoo.com

Kidney Transplantation Complications research center

Иран

A. ak. Khatibi

Mashhad university of medical sciences, Mashhad Iran.

Email: jalambadaniz@nums.ac.ir

Student Research committee, Faculty of Medicine

Иран

T. Zeraati

Mashhad university of medical sciences, Mashhad Iran.

Email: jhg@gmaail.com

Y. Ravanshad

Islamic Azad university of medical sciences, Mashhad, Iran

Email: lhhg@gmail.com

Department of Community Medicine, Mashhad Branch

Z. Jalambadani

Sabzevar University of Medical Sciences, Sabzevar, Iran

Author for correspondence.
Email: jalambadaniz@gmail.com

Assistant Professor of Health Education and Promotion,  Non-Communicable Diseases Research Center, Faculty of Medicine

Department of Community Medicine, Faculty of Medicine

Иран

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