ОСОБЕННОСТИ СОСТАВА МИКРОБИОТЫ ТОЛСТОЙ КИШКИ ПАЦИЕНТОВ С ИНФАРКТОМ МИОКАРДА 1 ТИПА С ПОДЪЕМОМ СЕГМЕНТА ST



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Abstract

Abstract

The relationship between the colonic biocenosis and the cardiovascular system is a relevant issue that has been thoroughly studied over the past 20 years. Nowadays, it has been proven that the intestinal microflora is able to regulate many host mechanisms, and its quantitative and qualitative changes trigger a cascade of pathological reactions. The main points of application through which the pathological effect is enabled are stimulation of systemic inflammation and lipid metabolism. Type 1 myocardial infarction with ST-segment elevation (STEMI) is the most dangerous form of coronary heart disease, often leading to death and disability. The aim of the study was to identify the features that determine the intraluminal colonic microbiota in patients with type 1 STEMI and estimate blood serum CRP level. The study enrolled 43 patients with type 1 STEMI aged 37 to 59 years. The first portion of feces was collected from and analyzed in patients with STEMI from the onset of clinical manifestations of the cardiovascular event. The control group consisted of age-matched conditionally healthy individuals (n=41) without a history of ACS. Patients with STEMI are characterized by a reduced number of Bifidobacterium spp., Enterococcus spp. and typical E. coli strains. In main group, non-motile strain of E. coli, Staphylococcus spp. and opportunistic bacteria, especially representatives of the genera Citrobacter and Kluyvera, were more common. In addition, 76% of patients in main group had leukocytosis and absolute monocytosis, and 100% of cases had elevated CRP levels. Thus, the clinical study presents data reflecting the taxonomic characteristics of colonic microbiota in patients with type 1 STEMI and their inflammatory profile. Dynamic observation of such patients seems promising for the long-term assessing interplay between intestinal microbiocenosis, cardiovascular continuum, and human immune system.

About the authors

Maksim Sergeevich Stepanov

E. A. Vagner Perm State Medical University;
State budgetary institution of Perm Krai "Clinical cardiology dispensary"

Email: maximpractice@gmail.com
ORCID iD: 0000-0002-3994-5461
SPIN-code: 4051-3732
Scopus Author ID: 57286845200

Postgraduate student and assistant of hospital
therapy and cardiology department; cardiologist

Россия, Petropavlovskaya street, 26, Perm, Russia 614990;

Natalia Sergeevna Karpunina

E. A. Vagner Perm State Medical University

Email: karpuninapsma@mail.ru
ORCID iD: 0000-0003-3127-1797
SPIN-code: 6562-9930
Scopus Author ID: 55943730200

Professor of the department of hospital therapy and cardiology of Perm State Medical University named after Academician E. A. Wagner, MD;

Россия, Petropavlovskaya street, 26, Perm, Russia

Anatoliy Petrovich Godovalov

E. A. Vagner Perm State Medical University;
Federal State Institution of Health Care "Medical Unit of the Ministry of Internal Affairs of Russia for Perm Krai"

Email: agodovalov@gmail.com
ORCID iD: 0000-0002-5112-2003
SPIN-code: 4482-4378
Scopus Author ID: 57204065570

Assistant professor of the department of hospital therapy and cardiology of Perm State Medical University named after Academician E. A. Wagner, PhD

Россия, Petropavlovskaya street, 26, Perm, Russia

Nadezhda Vasilevna Ipatova

E. A. Vagner Perm State Medical University

Author for correspondence.
Email: ipatova.nadya@bk.ru
ORCID iD: 0009-0005-9837-2949

6 year student

Petropavlovskaya street, 26, Perm, Russia

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Copyright (c) Stepanov M.S., Godovalov A.P., Karpunina N.S., Ipatova N.V.

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