Email this article SEVERITY-RELATED DIFFERENCES ON RESPONSE OF ANTIOXIDANT DEFENSE SYSTEM IN COVID-19 PATIENTS
- Authors: Shohrati M.1, Jafari M.1, Sadrzadeh M.1, Ebrahiminezhad H.1, Ghanei M.1
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Affiliations:
- Baqiyatallah University of Medical Sciences, Tehran, Iran
- Section: ORIGINAL ARTICLES
- Submitted: 19.11.2024
- Accepted: 29.07.2025
- URL: https://iimmun.ru/iimm/article/view/17819
- DOI: https://doi.org/10.15789/2220-7619-SRD-17819
- ID: 17819
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Abstract
Abstract
Background. COVID 19 is a major human infectious disease with devastating economic and public health impacts globally. Oxidative stress plays a pivotal role in the pathogenesis and progression of various viral infections. The aim of the present study was to evaluate oxidative stress biomarkers in COVID-19 patients with different severity to healthy participants.
Materials and methods. This case-control study was conducted on 60 patients with COVID‐19 infection (30 moderate and 30 severe) and 30 matched healthy controls referred to Baqiyatallah Hospital, Tehran from March until July 2020. Serum levels of total antioxidant capacity (TAC) and oxidative stress biomarkers such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) activities and levels of glutathione (GSH) and malondialdehyde (MDA) were measured using biochemical methods.
Results. In terms of gender, the healthy control group consisted of 17 males and 13 females, and the group of moderate patients included 20 males and 10 females and severe COVID-19 patients included 14 males and 16 females, which were not statistically significant (P=0.295). Also, the mean age in severe COVID-19 patients (46.6±12.8) was not significantly different from the healthy control (43.8±12; P=0.683) and moderate (45.60±13.30; P=0.953) groups. The results showed that SOD and CAT activities and MDA level in moderate and severe of COVID-19 patients were higher than the healthy individuals, while GPx and GR activities and GSH and TAC levels were significantly lower. SOD and GPx activities and MDA level in severe of COVID-19 patients were significantly different from moderate patients. However, CAT and GR activities and TAC level in severe cases was not significantly different from moderate patients.
Conclusion. Oxidative stress plays an important role in the pathogenesis of COVID 19 infection as indicated by the enhancement of lipid peroxidation, depletion of GSH and alteration in antioxidant enzymes. The systemic oxidative stress is directly related to the severity of the pathogenesis. Therefore, substances with antioxidant properties may be a potential choice for the treatment of COVID 19 infection.
About the authors
Majid Shohrati
Baqiyatallah University of Medical Sciences, Tehran, Iran
Email: majidshohrati@yahoo.com
PhD, Professor of PharmacologyDepartment of Clinical Pharmacy, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
ИранMahvash Jafari
Baqiyatallah University of Medical Sciences, Tehran, Iran
Email: m.jafari145@gmail.com
Ph.D., Professor of Biochemistry
Department of Biochemistry, Faculty of Medicine, Baqiyatallah University of Medical Sciences,Tehran - Iran
ИранMasoud Sadrzadeh
Baqiyatallah University of Medical Sciences, Tehran, Iran
Email: masoudsadr5468@gmail.com
Dr in Pharmacology Department of Clinical Pharmacy, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
ИранHamidreza Ebrahiminezhad
Baqiyatallah University of Medical Sciences, Tehran, Iran
Email: hamidrezaebi@yahoo.com
Dr in PharmacologyDepartment of Clinical Pharmacy, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
ИранMostafa Ghanei
Baqiyatallah University of Medical Sciences, Tehran, Iran
Author for correspondence.
Email: mghaneister@gmail.com
MD, Professor, PulmonologistChemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
ИранReferences
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).