THE STUDY OF VIRUSES REPRODUCTION IN CELL CULTURES BY THE METHOD OF MATHEMATICAL MODELING
- Authors: Kontarov N.A.1, Grishunina S.A.2, Balaev N.V.1, Yuminova N.V.1, Zverev V.V.1
- 
							Affiliations: 
							- Research Institute of Vaccines and Sera of I.I. Mechnikov RAMS, Moscow
- Lomonosov Moscow State University, Moscow
 
- Issue: Vol 3, No 4 (2013)
- Pages: 376-378
- Section: SHORT COMMUNICATIONS
- Submitted: 09.07.2014
- Accepted: 09.07.2014
- Published: 09.07.2014
- URL: https://iimmun.ru/iimm/article/view/150
- DOI: https://doi.org/10.15789/2220-7619-2013-4-376-378
- ID: 150
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Abstract
Abstract. In the study the mathematical analysis of viruses reproduction in cell culture using the Marchuk’ mathematical model to predict reproduction of virus in one or another cell cultures has been conducted. The obtained theoretical results are corresponded to the experimental data on reproduction of rubella virus in cell cultures RK-13 and BHK-21. The sum of theoretical and experimental results can be used to select the optimal cell cultures for virus cumulation.
About the authors
N. A. Kontarov
Research Institute of Vaccines and Sera of I.I. Mechnikov RAMS, Moscow
							Author for correspondence.
							Email: kontarov@mail.ru
				                					                																			                								
PhD (Biology), Senior Researcher, Laboratory of the Children’s Viral Infections, Department of Virology
127549, Russian Federation, Moscow, Muranovskaya str., 6, 218
РоссияS. A. Grishunina
Lomonosov Moscow State University, Moscow
														Email: kontarov@mail.ru
				                					                																			                								4th year student, Faculty of Mechanics and Mathematics				                	Россия													
N. V. Balaev
Research Institute of Vaccines and Sera of I.I. Mechnikov RAMS, Moscow
														Email: kontarov@mail.ru
				                					                																			                								PhD (Biology), Researcher, Laboratory of childhood viral infections, Department of Virology				                	Россия													
N. V. Yuminova
Research Institute of Vaccines and Sera of I.I. Mechnikov RAMS, Moscow
														Email: kontarov@mail.ru
				                					                																			                								PhD, MD (Biology), Deputy Director of Research				                	Россия													
V. V. Zverev
Research Institute of Vaccines and Sera of I.I. Mechnikov RAMS, Moscow
														Email: kontarov@mail.ru
				                					                																			                								PhD, MD (Biology), Professor, Full Member of the Russian Academy of Medical Sciences, Director				                	Россия													
References
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- Геронтология in silico: становление новой дисциплины: сб. науч. тр. / Под ред. Г.И. Марчука, В.Н. Анисимова, А.А. Романюхи, А.И. Яшина. — М.: БИНОМ, 2007. — 506 с. Gerontologiya in silico: stanovlenie novoy distsipliny: sb. nauch. tr. (Pod red. G.I. Marchuka, V.N. Anisimova, A.A. Romanyukhi, A.I. Yashina) [Gerontology in silico: formation of a new discipline: collection of scientific. Work of inst. (Ed. by G.I. Marchuk, V.N. Anisimov, A.A. Romanuycha, A.I. Yashin)]. Moscow, BINOM, 2007. 506 p.
- Контаров Н.А., Балаев Н.В., Контарова Е.О., Юминова Н.В., Зверев В.В. Оценка эффективности вакцинопрофилактики краснухи с помощью математического моделирования // Журнал инфектологии. — 2011. — Т. 3, № 3.– С. 29–30. Kontarov N.A., Balaev N.V., Kontarova E.O., Yuminova N.V., Zverev V.V. Otsenka effektivnosti vaktsinoprofilaktiki krasnukhi s pomoshch`yu matematicheskogo modelirovaniya [Evaluation of the effectiveness of vaccine prevention of rubella by mathematical modeling]. Zhurnal infektologii — Journal of Infectology, 2011, vol. 3, no. 3, pp. 29–30.
- Марчук Г.И. Математические модели в иммунологии. — М.: Наука, 1991. — 299 с. Marchuk G.I. Matematicheskie modeli v immunologii [Mathematical models in immunology]. Moscow, Nauka, 1991. 299 p.
- Мейхи Б. Вирусология. Методы. — М.: Мир, 1988. — 338 с. Meykhi B. Virusologiya. Metody [Virology. A practical approach]. Moscow, Mir, 1988. 338 p.
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