Russian Journal of Infection and ImmunityRussian Journal of Infection and Immunity2220-76192313-7398SPb RAACI15010.15789/2220-7619-2013-4-376-378THE STUDY OF VIRUSES REPRODUCTION IN CELL CULTURES BY THE METHOD OF MATHEMATICAL MODELINGKontarovN. A.<p>PhD (Biology), Senior Researcher, Laboratory of the Children’s Viral Infections, Department of Virology</p><p>127549, Russian Federation, Moscow, Muranovskaya str., 6, 218</p>kontarov@mail.ruGrishuninaS. A.4th year student, Faculty of Mechanics and Mathematicskontarov@mail.ruBalaevN. V.PhD (Biology), Researcher, Laboratory of childhood viral infections, Department of Virologykontarov@mail.ruYuminovaN. V.PhD, MD (Biology), Deputy Director of Researchkontarov@mail.ruZverevV. V.PhD, MD (Biology), Professor, Full Member of the Russian Academy of Medical Sciences, Directorkontarov@mail.ruResearch Institute of Vaccines and Sera of I.I. Mechnikov RAMS, MoscowLomonosov Moscow State University, Moscow08072013343763780907201409072014Copyright © 2014, Kontarov N.A., Grishunina S.A., Balaev N.V., Yuminova N.V., Zverev V.V.2014<p><strong>Abstract.</strong> In the study the mathematical analysis of viruses reproduction in cell culture using the Marchuk’ mathematical model to predict reproduction of virus in one or another cell cultures has been conducted. The obtained theoretical results are corresponded to the experimental data on reproduction of rubella virus in cell cultures RK-13 and BHK-21. The sum of theoretical and experimental results can be used to select the optimal cell cultures for virus cumulation.</p>multiplication of the viruscell culturemathematical model Marchuka stable nodeразмножение вирусакультура клетокматематическая модель Марчукаустойчивый узел[1. Балаев Н.В. Оценка эффективности вакцинопрофилактики краснухи на территории РФ. — Дис. ... канд. биол. наук. — М., 2013. — 107 с. Balaev N.V. Otsenka effektivnosti vaktsinoprofilaktiki krasnukhi na territorii RF. Diss. ... cand. biol. nauk [Evaluation of the effectiveness of vaccine prevention of rubella in the territory of the Russian Federation. Autoref. Сand. biol. sci. diss]. Moscow, 2013. 107 p.][2. Геронтология in silico: становление новой дисциплины: сб. науч. тр. / Под ред. Г.И. Марчука, В.Н. Анисимова, А.А. Романюхи, А.И. Яшина. — М.: БИНОМ, 2007. — 506 с. Gerontologiya in silico: stanovlenie novoy distsipliny: sb. nauch. tr. (Pod red. G.I. Marchuka, V.N. Anisimova, A.A. Romanyukhi, A.I. Yashina) [Gerontology in silico: formation of a new discipline: collection of scientific. Work of inst. (Ed. by G.I. Marchuk, V.N. Anisimov, A.A. Romanuycha, A.I. Yashin)]. Moscow, BINOM, 2007. 506 p.][3. Контаров Н.А., Балаев Н.В., Контарова Е.О., Юминова Н.В., Зверев В.В. Оценка эффективности вакцинопрофилактики краснухи с помощью математического моделирования // Журнал инфектологии. — 2011. — Т. 3, № 3.– С. 29–30. Kontarov N.A., Balaev N.V., Kontarova E.O., Yuminova N.V., Zverev V.V. Otsenka effektivnosti vaktsinoprofilaktiki krasnukhi s pomoshch`yu matematicheskogo modelirovaniya [Evaluation of the effectiveness of vaccine prevention of rubella by mathematical modeling]. Zhurnal infektologii — Journal of Infectology, 2011, vol. 3, no. 3, pp. 29–30.][4. Марчук Г.И. Математические модели в иммунологии. — М.: Наука, 1991. — 299 с. Marchuk G.I. Matematicheskie modeli v immunologii [Mathematical models in immunology]. Moscow, Nauka, 1991. 299 p.][5. Мейхи Б. Вирусология. Методы. — М.: Мир, 1988. — 338 с. Meykhi B. Virusologiya. Metody [Virology. A practical approach]. Moscow, Mir, 1988. 338 p.]