THE STUDY OF VIRUSES REPRODUCTION IN CELL CULTURES BY THE METHOD OF MATHEMATICAL MODELING

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Abstract. In the study the mathematical analysis of viruses reproduction in cell culture using the Marchuk’ mathematical model to predict  reproduction of virus in one or another cell cultures has been conducted. The obtained theoretical results are corresponded to the experimental data on reproduction of rubella virus in cell cultures RK-13 and BHK-21. The sum of theoretical and experimental results can be used to select the optimal cell cultures for virus cumulation.

About the authors

N. A. Kontarov

Research Institute of Vaccines and Sera of I.I. Mechnikov RAMS, Moscow

Author for correspondence.
Email: kontarov@mail.ru

PhD (Biology), Senior Researcher, Laboratory of the Children’s Viral Infections, Department of Virology

127549, Russian Federation, Moscow, Muranovskaya str., 6, 218

Россия

S. A. Grishunina

Lomonosov Moscow State University, Moscow

Email: kontarov@mail.ru
4th year student, Faculty of Mechanics and Mathematics Россия

N. V. Balaev

Research Institute of Vaccines and Sera of I.I. Mechnikov RAMS, Moscow

Email: kontarov@mail.ru
PhD (Biology), Researcher, Laboratory of childhood viral infections, Department of Virology Россия

N. V. Yuminova

Research Institute of Vaccines and Sera of I.I. Mechnikov RAMS, Moscow

Email: kontarov@mail.ru
PhD, MD (Biology), Deputy Director of Research Россия

V. V. Zverev

Research Institute of Vaccines and Sera of I.I. Mechnikov RAMS, Moscow

Email: kontarov@mail.ru
PhD, MD (Biology), Professor, Full Member of the Russian Academy of Medical Sciences, Director Россия

References

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  2. Геронтология in silico: становление новой дисциплины: сб. науч. тр. / Под ред. Г.И. Марчука, В.Н. Анисимова, А.А. Романюхи, А.И. Яшина. — М.: БИНОМ, 2007. — 506 с. Gerontologiya in silico: stanovlenie novoy distsipliny: sb. nauch. tr. (Pod red. G.I. Marchuka, V.N. Anisimova, A.A. Romanyukhi, A.I. Yashina) [Gerontology in silico: formation of a new discipline: collection of scientific. Work of inst. (Ed. by G.I. Marchuk, V.N. Anisimov, A.A. Romanuycha, A.I. Yashin)]. Moscow, BINOM, 2007. 506 p.
  3. Контаров Н.А., Балаев Н.В., Контарова Е.О., Юминова Н.В., Зверев В.В. Оценка эффективности вакцинопрофилактики краснухи с помощью математического моделирования // Журнал инфектологии. — 2011. — Т. 3, № 3.– С. 29–30. Kontarov N.A., Balaev N.V., Kontarova E.O., Yuminova N.V., Zverev V.V. Otsenka effektivnosti vaktsinoprofilaktiki krasnukhi s pomoshch`yu matematicheskogo modelirovaniya [Evaluation of the effectiveness of vaccine prevention of rubella by mathematical modeling]. Zhurnal infektologii — Journal of Infectology, 2011, vol. 3, no. 3, pp. 29–30.
  4. Марчук Г.И. Математические модели в иммунологии. — М.: Наука, 1991. — 299 с. Marchuk G.I. Matematicheskie modeli v immunologii [Mathematical models in immunology]. Moscow, Nauka, 1991. 299 p.
  5. Мейхи Б. Вирусология. Методы. — М.: Мир, 1988. — 338 с. Meykhi B. Virusologiya. Metody [Virology. A practical approach]. Moscow, Mir, 1988. 338 p.

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Copyright (c) 2014 Kontarov N.A., Grishunina S.A., Balaev N.V., Yuminova N.V., Zverev V.V.

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