Etiology of influenza-like illnesses in the population of Novosibirsk city in the 2018–2019 epidemic season

Cover Page

Cite item

Abstract

Influenza and other acute respiratory viral infections lead to a substantial incidence of severe cases and hospitalizations and so remain a global health problem. Within the frame of the Global Influenza Hospital Surveillance Network (GIHSN), we assessed the contribution of influenza and other respiratory viruses to severe cases of influenzalike diseases in patients hospitalized to the Novosibirsk infectious hospitals in the years 2018–2019. We analyzed 484 nasopharyngeal swabs collected from patients admitted to the hospitals with acute respiratory infections (ARI) using real-time polymerase chain reaction commercial kits. We confirmed viral etiology of ARI in 69.8% cases. Influenza viruses were detected in 47.1% cases, wherein concomitant circulation of influenza A(H1N1)pdm09 and A(H3N2) viruses was observed in 20.7% and 26% of patients, respectively, whereas influenza B virus was detected only in one sample. All analyzed influenza A viruses were antigenically similar to vaccine strains. Genetically, the Novosibirsk strains were closely related to influenza A viruses distributed in Russia and worldwide. Influenza A(H1N1)pdm09 virus was detected in all patients aged 0 to 14 years and required intensive care. Other respiratory viruses were detected in 36.4% of children and 5.8% of adults, and 8.3% of children had viral coinfection, whereas no cases of coinfection were detected in adults. The most common viruses in children were metapneumovirus — 12.8%, rhinovirus — 9.3% and respiratory syncytial virus — 8.0%. In adults, metapneumovirus, adenovirus, parainfluenza virus and rhinovirus were detected with a detection rate no exceeding 2%. In this study, we found no differences in the detection rate of the influenza virus due to concomitant chronic diseases, pregnancy, or smoking habits. At the same time, the detection rate of other respiratory viruses in non-smokers vs. smokers was significantly lower than in smokers and former smokers (26.15%, 66.67% and 62.50%, respectively). In addition, the level of detection of respiratory viruses in children with vs. without chronic pathology was significantly higher (55.3% and 38.7%, respectively). Thus, our and similar studies are important for monitoring and control of the infection.

About the authors

O. G. Kurskaya

Federal Research Center of Fundamental and Translational Medicine

Author for correspondence.
Email: kurskaya_og@mail.ru
ORCID iD: 0000-0002-1931-2026

Olga G. Kurskaya,  PhD (Medicine), Senior Researcher, Department of Experimental Modelling and Pathogenesis of Infectious Diseases 

630117, Novosibirsk, Timakov str., 2

Phone: +7 913 741-23-46 (mobile) 

Russian Federation

A. V. Anoshina

Novosibirsk Children’s Municipal Clinical Hospital No. 6

Email: anzhelika.anoshina2010@yandex.ru

PhD (Medicine), Head of the Department of Infectious Diseases

Novosibirsk 

Russian Federation

N. V. Leonova

Novosibirsk Children’s Municipal Clinical Hospital No. 6

Email: mbuz_dgb6@mail.ru

Head Physician

Novosibirsk 

Russian Federation

O. A. Simkina

Novosibirsk Children’s Municipal Clinical Hospital No. 3

Email: olgasimkina83@yandex.ru

Epidemiologist

Novosibirsk 

Russian Federation

T. V. Komissarova

Novosibirsk Children’s Municipal Clinical Hospital No. 3

Email: dgkb3@nso.ru

PhD (Medicine), Head Physician

Novosibirsk 

Russian Federation

E. Yu. Esikova

Novosibirsk Municipal Infectious Clinical Hospital No. 1

Email: elenaesikov@yandex.ru

Infectologist

Novosibirsk 

Russian Federation

L. L. Pozdnyakova

Novosibirsk Municipal Infectious Clinical Hospital No. 1

Email: gikb1@nso.ru

PhD (Medicine), Honored Physician of the Russian Federation, Head Physician

Novosibirsk 

Russian Federation

I. A. Sobolev

Federal Research Center of Fundamental and Translational Medicine 

Email: sobolev_i@hotmail.com
ORCID iD: 0000-0002-4561-6517

PhD (Biology), Researcher

Novosibirsk 

Russian Federation

E. A. Prokopyeva

Federal Research Center of Fundamental and Translational Medicine 

Email: e.prokopeva@g.nsu.ru
ORCID iD: 0000-0002-5349-8362

PhD (Biology), Senior Researcher

Novosibirsk 

Russian Federation

Т. A. Murashkina

Federal Research Center of Fundamental and Translational Medicine 

Email: murashkinatatiana89@gmail.com

Junior Researcher

Novosibirsk 

Russian Federation

E. A. Kazachkova

Federal Research Center of Fundamental and Translational Medicine 

Email: evgesha_c@mail.ru

Junior Researcher

Novosibirsk 

Russian Federation

А. Yu. Alekseev

Federal Research Center of Fundamental and Translational Medicine 

Email: al-alexok@ngs.ru

PhD (Biology), Senior Researcher, Head of the Laboratory of Experimental Modelling and Pathogenesis of Infectious Diseases

Novosibirsk 

Russian Federation

D. M. Danilenko

Smorodintsev Research Institute of Influenza

Email: daria.baibus@gmail.com
ORCID iD: 0000-0001-6174-0836

PhD (Biology), Deputy Director for Science Work, Head of the Department of Etiology and Epidemiology

St. Petersburg

Russian Federation

A. B. Komissarov

Smorodintsev Research Institute of Influenza

Email: andrey.komissarov@influenza.spb.ru
ORCID iD: 0000-0003-1733-1255

Head of the Laboratory of Molecular Virology

St. Petersburg 

Russian Federation

K. A. Stolyarov

Smorodintsev Research Institute of Influenza

Email: kirill@influenza.spb.ru
ORCID iD: 0000-0002-1765-2799

Leading Programmist

St. Petersburg 

Russian Federation

A. V. Fadeev

Smorodintsev Research Institute of Influenza

Email: afadeew@gmail.com
ORCID iD: 0000-0003-3558-3261

Researcher

St. Petersburg 

Russian Federation

A. A. Sominina

Smorodintsev Research Institute of Influenza

Email: anna.sominina@influenza.spb.ru
ORCID iD: 0000-0001-9671-0629

PhD (Medicine), Professor, Honoured Scientist of the Russian Federation, Head of the Laboratory for Studying Risk Factors of Influenza and Acute Respiratory Infections

St. Petersburg 

Russian Federation

А. M. Shestopalov

Federal Research Center of Fundamental and Translational Medicine 

Email: shestopalov2@ngs.ru

PhD, MD (Biology), Professor, Head of the Department of Experimental Modelling and Pathogenesis of Infectious Diseases

Novosibirsk 

Russian Federation

K. A. Sharshov

Federal Research Center of Fundamental and Translational Medicine 

Email: sharshov@yandex.ru
ORCID iD: 0000-0002-3946-9872

PhD (Biology), Senior Researcher, Head of the Laboratory of Developing and Drug Testing

Novosibirsk 

Russian Federation

References

  1. Львов Н.И., Писарева М.М., Мальцев О.В., Бузицкая Ж.В., Афанасьева В.С., Михайлова М.А., Го А., Янина М.А., Резниченко Н.А., Грудинин М.П., Жданов К.В., Лобзин Ю.В. Особенности этиологической структуры ОРВИ в отдельных возрастных и профессиональных группах населения Санкт-Петербурга в эпидемический сезон 2013–2014 гг. // Журнал инфектологии. 2014. Т. 6, № 3, C. 62–70. [Lvov N.I., Pisareva M.M., Maltsev O.V., Buzitskaya J.V., Afanasieva V.S., Mikhailova M.A., Go A., Yanina M.A., Reznichenko N.A., Grudinin M.P., Zhdanov K.V., Lobzin Y.V. The features of ARVD etiological structure in different age and professional population groups in Saint-Petersburg during 2013–2014 epidemic season. Zhurnal infektologii = Journal of Infectology, 2014, vol. 6, no. 3, pp. 62–70. (In Russ.)] doi: 10.22625/2072-6732-2014-6-3-62-70
  2. Роспотребнадзор. Итоги прошлого эпидсезона гриппа (2018–2019 гг.) и прогноз на новый сезон 2019–2020 гг. [Russian Federal Service on Surveillance for Consumer Rights Protection and Human Well-being (Rospotrebnadzor). About the results of the epidemic season of influenza (2018–2019), forecast for the 2019–2020 epidemic season. (In Russ.)] URL: http://41.rospotrebnadzor.ru/content/itogi-proshlogo-epidsezona-grippa-2018-2019-gg-i-prognoz-na-novyy-sezon-2019-2020-gg (12.02.2021)
  3. Asha K., Kumar B. Emerging influenza D virus threat: what we know so far! J. Clin. Med., 2019, vol. 8, no. 2: 192. doi: 10.3390/jcm8020192
  4. Baselga-Moreno V., Trushakova S., McNeil S., Sominina A., Nunes M.C., Draganescu A., Unal S., Koul P., Kyncl J., Zhang T., Kuatbayeva A., Ben-Salah A., Burtseva E., Puig-Barberà J., Díez-Domingo J. for the Global Influenza Hospital Surveillance Network (GIHSN). Influenza epidemiology and influenza vaccine effectiveness during the 2016–2017 season in the Global Influenza Hospital Surveillance Network (GIHSN). BMC Public Health, 2019, no. 19: 487. doi: 10.1186/s12889-019-6713-5
  5. Dong W., Chen Q., Hu Y., He D., Liu J., Yan H. Epidemiological and clinical characteristics of respiratory viral infections in children in Shanghai, China. Arch. Virol., 2016, no. 161, pp. 1907–1913. doi: 10.1007/s00705-016-2866-z
  6. Feng L., Li Z., Zhao S., Nair H., Lai S., Xu W., Li M., Wu J., Ren L., Liu W., Yuan Z., Chen Y., Wang X., Zhao Z., Zhang H., Li F., Ye X., Li S., Feikin D., Yu H., Yang W. Viral etiologies of hospitalized acute lower respiratory infection patients in China, 2009–2013. PLoS One, 2014, vol. 9, no. 6: e99419. doi: 10.1371/journal.pone.0099419
  7. Global Influenza Hospital Surveillance Network. The Global Influenza Hospital Surveillance Network (GIHSN). GIHSN, 2018. 11 p.
  8. Ju X., Fang Q., Zhang J., Xu A., Liang L., Ke C. Viral etiology of influenza-like illnesses in Huizhou, China, from 2011 to 2013. Arch. Virol., 2014, vol. 159, no. 8, pp. 2003–2010. doi: 10.1007/s00705-014-2035-1
  9. Kurskaya O., Ryabichenko T., Leonova N., Shi W., Bi H., Sharshov K., Kazachkova E., Sobolev I., Prokopyeva E., Kartseva T., Alekseev A., Shestopalov A. Viral etiology of acute respiratory infections in hospitalized children in Novosibirsk City, Russia (2013–2017). PLoS One, 2018, vol. 13, no. 9: e0200117. doi: 10.1371/journal.pone.0200117
  10. McCauley J.W., Hongo S., Kaverin N.V., Kochs G., Lamb R.A., Matrosovich M.N., Perez D.R., Palese P., Presti R.M., Rimstad E. Virus taxonomy. In: Classification and nomenclature of viruses: ninth report of the international committee on taxonomy of viruses. Ed. by King A.M.Q., Lefkowitz E., Adams M.J., Carstens E.B. San Diego: Elsevier Academic Press, 2012, pp. 749–761.
  11. Ortiz J.R., Neuzil K.M., Shay D.K., Rue T.C., Neradilek M.B., Zhou H., Seymour C.W., Hooper L.G., Cheng P.Y., Goss C.H., Cooke C.R. The burden of influenza-associated critical illness hospitalizations. Crit. Care Med., 2014, vol. 42, no. 11, pp. 2325– 2332. doi: 10.1097/ccm.0000000000000545
  12. Puig-Barberà J., Mira-Iglesias A., Burtseva E., Cowling B.J., Serhat U., Ruiz-Palacios G.M., Launay O., Kyncl J., Koul P., Siqueira M.M., Sominina A.; Global Influenza Hospital Surveillance. Network Influenza epidemiology and influenza vaccine effectiveness during the 2015–2016 season: results from the Global Influenza Hospital Surveillance Network. BMC Infect. Dis., 2019, vol. 19: 415. doi: 10.1186/s12879-019-4017-0
  13. Puig-Barberà J., Tormos A., Sominina A., Burtseva E., Launay O., Ciblak M.A., Natividad-Sancho A., Buigues-Vila A., Martínez-Úbeda S., Mahé C.; GIHSN Group. First-year results of the Global Influenza Hospital Surveillance Network: 2012– 2013 Northern hemisphere influenza season. BMC Public Health, 2014, vol. 14: 564. doi: 10.1186/1471-2458-14-564
  14. Puig-Barberà J., Tormos A., Trushakova A., Sominina A., Pisareva M., Ciblak M.A., Badur S., Yu H., Cowling B.J., Burtseva E., on behalf of the GIHSN Group. The Global Influenza Hospital Surveillance Network (GIHSN): a new platform to describe the epidemiology of severe influenza. Influenza Other Respir. Viruses, 2015, vol. 9, no. 6, pp. 277–286. doi: 10.1111/irv.12335
  15. WHO. Guidelines for pharmacological management of pandemic influenza A (H1N1) 2009 and other influenza viruses. Revised February 2010. Part I. Recommendations. WHO, 2010. 32 p.
  16. WIC, WHO CC for Reference and Research on Influenza, FCI. Report prepared for the WHO annual consultation on the composition of influenza vaccines for the Southern Hemisphere 2020. 23rd – 26th September 2019. WIC, WHO CC for Reference and Research on Influenza, FCI, 2019. 149 p.
  17. Zhou B., Lin X., Wang W., Halpin R.A., Bera J., Stockwell T.B., Barr I.G., Wentworth D.E. Universal Influenza B virus genomic amplification facilitates sequencing, diagnostics, and reverse genetics. J. Clin. Microbiol., 2014, vol. 52, no. 5, pp. 1330–1337. doi: 10.1128/jcm.03265-13

Supplementary files

There are no supplementary files to display.


Copyright (c) 2021 Kurskaya O.G., Anoshina A.V., Leonova N.V., Simkina O.A., Komissarova T.V., Esikova E.Y., Pozdnyakova L.L., Sobolev I.A., Prokopyeva E.A., Murashkina Т.A., Kazachkova E.A., Alekseev А.Y., Danilenko D.M., Komissarov A.B., Stolyarov K.A., Fadeev A.V., Sominina A.A., Shestopalov А.M., Sharshov K.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies