Etiology of influenza-like illnesses in the population of Novosibirsk city in the 2018–2019 epidemic season
- Authors: Kurskaya O.G.1, Anoshina A.V.2, Leonova N.V.2, Simkina O.A.3, Komissarova T.V.3, Esikova E.Y.4, Pozdnyakova L.L.4, Sobolev I.A.5, Prokopyeva E.A.5, Murashkina Т.A.5, Kazachkova E.A.5, Alekseev А.Y.5, Danilenko D.M.6, Komissarov A.B.6, Stolyarov K.A.6, Fadeev A.V.6, Sominina A.A.6, Shestopalov А.M.5, Sharshov K.A.5
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Affiliations:
- Federal Research Center of Fundamental and Translational Medicine
- Novosibirsk Children’s Municipal Clinical Hospital No. 6
- Novosibirsk Children’s Municipal Clinical Hospital No. 3
- Novosibirsk Municipal Infectious Clinical Hospital No. 1
- Federal Research Center of Fundamental and Translational Medicine
- Smorodintsev Research Institute of Influenza
- Issue: Vol 11, No 4 (2021)
- Pages: 723-736
- Section: ORIGINAL ARTICLES
- Submitted: 03.04.2020
- Accepted: 26.05.2020
- Published: 13.05.2021
- URL: https://iimmun.ru/iimm/article/view/1439
- DOI: https://doi.org/10.15789/2220-7619-EOI-1439
- ID: 1439
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Abstract
Influenza and other acute respiratory viral infections lead to a substantial incidence of severe cases and hospitalizations and so remain a global health problem. Within the frame of the Global Influenza Hospital Surveillance Network (GIHSN), we assessed the contribution of influenza and other respiratory viruses to severe cases of influenzalike diseases in patients hospitalized to the Novosibirsk infectious hospitals in the years 2018–2019. We analyzed 484 nasopharyngeal swabs collected from patients admitted to the hospitals with acute respiratory infections (ARI) using real-time polymerase chain reaction commercial kits. We confirmed viral etiology of ARI in 69.8% cases. Influenza viruses were detected in 47.1% cases, wherein concomitant circulation of influenza A(H1N1)pdm09 and A(H3N2) viruses was observed in 20.7% and 26% of patients, respectively, whereas influenza B virus was detected only in one sample. All analyzed influenza A viruses were antigenically similar to vaccine strains. Genetically, the Novosibirsk strains were closely related to influenza A viruses distributed in Russia and worldwide. Influenza A(H1N1)pdm09 virus was detected in all patients aged 0 to 14 years and required intensive care. Other respiratory viruses were detected in 36.4% of children and 5.8% of adults, and 8.3% of children had viral coinfection, whereas no cases of coinfection were detected in adults. The most common viruses in children were metapneumovirus — 12.8%, rhinovirus — 9.3% and respiratory syncytial virus — 8.0%. In adults, metapneumovirus, adenovirus, parainfluenza virus and rhinovirus were detected with a detection rate no exceeding 2%. In this study, we found no differences in the detection rate of the influenza virus due to concomitant chronic diseases, pregnancy, or smoking habits. At the same time, the detection rate of other respiratory viruses in non-smokers vs. smokers was significantly lower than in smokers and former smokers (26.15%, 66.67% and 62.50%, respectively). In addition, the level of detection of respiratory viruses in children with vs. without chronic pathology was significantly higher (55.3% and 38.7%, respectively). Thus, our and similar studies are important for monitoring and control of the infection.
About the authors
O. G. Kurskaya
Federal Research Center of Fundamental and Translational Medicine
Author for correspondence.
Email: kurskaya_og@mail.ru
ORCID iD: 0000-0002-1931-2026
Olga G. Kurskaya, PhD (Medicine), Senior Researcher, Department of Experimental Modelling and Pathogenesis of Infectious Diseases
630117, Novosibirsk, Timakov str., 2
Phone: +7 913 741-23-46 (mobile)
РоссияA. V. Anoshina
Novosibirsk Children’s Municipal Clinical Hospital No. 6
Email: anzhelika.anoshina2010@yandex.ru
PhD (Medicine), Head of the Department of Infectious Diseases
Novosibirsk
РоссияN. V. Leonova
Novosibirsk Children’s Municipal Clinical Hospital No. 6
Email: mbuz_dgb6@mail.ru
Head Physician
Novosibirsk
РоссияO. A. Simkina
Novosibirsk Children’s Municipal Clinical Hospital No. 3
Email: olgasimkina83@yandex.ru
Epidemiologist
Novosibirsk
РоссияT. V. Komissarova
Novosibirsk Children’s Municipal Clinical Hospital No. 3
Email: dgkb3@nso.ru
PhD (Medicine), Head Physician
Novosibirsk
РоссияE. Yu. Esikova
Novosibirsk Municipal Infectious Clinical Hospital No. 1
Email: elenaesikov@yandex.ru
Infectologist
Novosibirsk
РоссияL. L. Pozdnyakova
Novosibirsk Municipal Infectious Clinical Hospital No. 1
Email: gikb1@nso.ru
PhD (Medicine), Honored Physician of the Russian Federation, Head Physician
Novosibirsk
РоссияI. A. Sobolev
Federal Research Center of Fundamental and Translational Medicine
Email: sobolev_i@hotmail.com
ORCID iD: 0000-0002-4561-6517
PhD (Biology), Researcher
Novosibirsk
РоссияE. A. Prokopyeva
Federal Research Center of Fundamental and Translational Medicine
Email: e.prokopeva@g.nsu.ru
ORCID iD: 0000-0002-5349-8362
PhD (Biology), Senior Researcher
Novosibirsk
РоссияТ. A. Murashkina
Federal Research Center of Fundamental and Translational Medicine
Email: murashkinatatiana89@gmail.com
Junior Researcher
Novosibirsk
РоссияE. A. Kazachkova
Federal Research Center of Fundamental and Translational Medicine
Email: evgesha_c@mail.ru
Junior Researcher
Novosibirsk
РоссияА. Yu. Alekseev
Federal Research Center of Fundamental and Translational Medicine
Email: al-alexok@ngs.ru
PhD (Biology), Senior Researcher, Head of the Laboratory of Experimental Modelling and Pathogenesis of Infectious Diseases
Novosibirsk
РоссияD. M. Danilenko
Smorodintsev Research Institute of Influenza
Email: daria.baibus@gmail.com
ORCID iD: 0000-0001-6174-0836
PhD (Biology), Deputy Director for Science Work, Head of the Department of Etiology and Epidemiology
St. Petersburg
РоссияA. B. Komissarov
Smorodintsev Research Institute of Influenza
Email: andrey.komissarov@influenza.spb.ru
ORCID iD: 0000-0003-1733-1255
Head of the Laboratory of Molecular Virology
St. Petersburg
РоссияK. A. Stolyarov
Smorodintsev Research Institute of Influenza
Email: kirill@influenza.spb.ru
ORCID iD: 0000-0002-1765-2799
Leading Programmist
St. Petersburg
РоссияA. V. Fadeev
Smorodintsev Research Institute of Influenza
Email: afadeew@gmail.com
ORCID iD: 0000-0003-3558-3261
Researcher
St. Petersburg
РоссияA. A. Sominina
Smorodintsev Research Institute of Influenza
Email: anna.sominina@influenza.spb.ru
ORCID iD: 0000-0001-9671-0629
PhD (Medicine), Professor, Honoured Scientist of the Russian Federation, Head of the Laboratory for Studying Risk Factors of Influenza and Acute Respiratory Infections
St. Petersburg
РоссияА. M. Shestopalov
Federal Research Center of Fundamental and Translational Medicine
Email: shestopalov2@ngs.ru
PhD, MD (Biology), Professor, Head of the Department of Experimental Modelling and Pathogenesis of Infectious Diseases
Novosibirsk
РоссияK. A. Sharshov
Federal Research Center of Fundamental and Translational Medicine
Email: sharshov@yandex.ru
ORCID iD: 0000-0002-3946-9872
PhD (Biology), Senior Researcher, Head of the Laboratory of Developing and Drug Testing
Novosibirsk
РоссияReferences
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