COMPARE THE LEVEL OF SQUAMOUS CELL CARCINOMA ANTIGEN IN SERUM AND LOCAL IMMUNITY OF THE REPRODUCTIVE TRACT IN WOMEN WITH INVASIVE FORM OF CERVICAL CANCER

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Abstract

Abstract. Cervical cancer continues to take a leading position in the structure of cancer pathology in women. This situation calls for the search for new diagnostic criteria for prognosis of the disease. The study found that tumor marker SCCA is immunologically dependent and its detection should be carried out in conjunction with immunological parameters of cervical mucus. This is important not only for diagnosis but also for monitoring of anticancer therapy conducted to determine prognosis of the disease and preclinical detection recurrence of cervical cancer.

About the authors

I. L. Baturina

State Educational Institution of Higher Professional Education «South Ural Medical University» of Ministry of Health of the Russian Federation, Chelyabinsk

Author for correspondence.
Email: irisha_baturina@mail.ru

Researcher, Research Institute of Immunology

454000, Russian Federation, Chelyabinsk, Salavat Yulaev str., 26-168

 

Russian Federation

I. U. Orner

State Educational Institution of Higher Professional Education «South Ural Medical University» of Ministry of Health of the Russian Federation, Chelyabinsk

Email: irisha_baturina@mail.ru
Researcher, Research Institute of Immunology Russian Federation

M. A. Zotova

State Educational Institution of Higher Professional Education «South Ural Medical University» of Ministry of Health of the Russian Federation, Chelyabinsk

Email: irisha_baturina@mail.ru
Researcher, Research Institute of Immunology Russian Federation

O. S. Abramovskih

State Educational Institution of Higher Professional Education «South Ural Medical University» of Ministry of Health of the Russian Federation, Chelyabinsk

Email: irisha_baturina@mail.ru
Professor, Department of Microbiology, Immunology, Virology and Clinical Laboratory Diagnostics Russian Federation

K. V. Nikushkina

State Educational Institution of Higher Professional Education «South Ural Medical University» of Ministry of Health of the Russian Federation, Chelyabinsk

Email: irisha_baturina@mail.ru
Leading Researcher, Research Institute of Immunology Russian Federation

L. F. Telesheva

State Educational Institution of Higher Professional Education «South Ural Medical University» of Ministry of Health of the Russian Federation, Chelyabinsk

Email: irisha_baturina@mail.ru
Professor, Department of Microbiology, Immunology, Virology and Clinical Laboratory Diagnostics, Vice-Rector for Research Russian Federation

References

  1. Дубовецкая О.Б. Диагностический алгоритм использования серологического опухолевого маркера SCC у больных раком шейки матки: дис. ... канд. мед. наук. — М., 2005. — 123 с. Dubovetskaia O.B. Diagnosticheskii algoritm ispol’zovaniia serologicheskogo opukholevogo markera SCC u bol’nykh rakom sheiki matki: dis. kand. med. nauk [Diagnostic algorithm of using serologic tumor marker SCC in patients with cervical cancer: cand. med. sci. diss.]. Moscow, 2005, 123 p.
  2. Евстигнеева Л.А., Бахидзе Е.В., Семиглазов В.В. Иммунологический статус у больных карциномой in situ и инвазивным раком шейки матки // Материалы V съезда онкологов и радиологов СНГ (Ташкент, 14–16 мая 2008 г.). — Ташкент, 2008. — С. 93. Evstigneeva L.A., Bakhidze E.V., Semiglazov V.V. Immunologicheskii status u bol’nykh kartsinomoi in situ i invazivnym rakom sheiki matki [Immunological status of patients with carcinoma in situ and invasive cervical cancer]. Materialy V s”ezda onkologov i radiologov SNG (Tashkent, 14–16 maia 2008 goda) [Materials of the V Congress of oncologists and radiologists CIS (Tashkent, 14–16 May 2008)]. Tashkent, 2008, p. 93.
  3. Мальцева В.Н. Респираторный взрыв и особенности его регуляции в периферических нейтрофилах при росте опухоли in vivo: дис. ... канд. биол. наук. — Пущино, 2007. — 138 с. Mal’tseva V.N. Respiratornyi vzryv i osobennosti ego reguliatsii v perifericheskikh neitrofilakh pri roste opukholi in vivo: dis. kand. biol. nauk [Respiratory burst and particularly its regulation in peripheral neutrophils in tumor growth in vivo: cand. biol. sci. diss.]. Pushchino, 2007, 138 p.
  4. Русскова А.Н. Новые сведения об иммуносупрессии // Междунар. журн. эксперим. образования. — 2010. — № 8. — С. 47–49. Russkova A.N. Novye svedeniia ob immunosupressii [New information about immunosuppression]. Mezhdunarodnyi zhurnal eksperimental’nogo obrazovaniia — International Journal of Experimental Education, 2010, no. 8, pp. 47–49.
  5. Borras G., Molina R., Xercavins J., Ballesta A., Iglesias X. Squamous cell carcinoma antigen in cervical cancer. Eur. Gynaecol. Oncol., 1999, vol. 13, no. 5, pp. 414–418.
  6. Davelaar E.M., van de Lande J., von Mensdorff-Pouilly S., Blankenstein M.A., Verheijen R.H., Kenemans P. A combination of serum tumor markers identifies high risk patients with early-stage squamous cervical cancer. Tumour. Biol., 2008, vol. 29, no. 1, pp. 9–17.
  7. Ogino I., Nakayama H., Okamoto N., Kitamura T., Inoue T. The role of pretreatment squamous cell carcinoma antigen level in locally advanced squamous cell carcinoma of the uterine cervix treated by radiotherapy. Int. J. Gynecol. Cancer, 2006, vol. 16, no. 3, pp. 1094–1100.

Copyright (c) 2014 Baturina I.L., Orner I.U., Zotova M.A., Abramovskih O.S., Nikushkina K.V., Telesheva L.F.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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