MYCOBACTERIUM TUBERCULOSIS VIRULENCE

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Abstract

This review presents recent data on the genetic determinants and the virulence factors of Mycobacterium tuberculosis (MBT). The mechanisms of adaptation of the pathogen in the host organism and alterative manifestations are described as well as the relationship of virulence, drug resistance and the genetic affiliation of MBT are analyzed in the
article. It was demonstrated the clinical and prognostic significance of Mycobacterium tuberculosis virulence. The cyclic changes in MBT virulence coincide with the rise and fall of the incidence of tuberculosis has been established. Some virulence factors are targets to create fundamentally new anti-TB drugs.

About the authors

B. I. Vishnevskiy

St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg, Russian Federation 194064, Russian Federation, St. Petersburg, olitekhnicheskaya str., 32, St. Petersburg Research Institute of Phthisiopulmonology.
Phone: +7 (812) 297-16-26. Fax: +7 (812) 237-16-26

Author for correspondence.
Email: bivish@rambler.ru

PhD, MD (Medicine), Professor, Head Researcher of St. Petersburg Research Institute Phthisiopulmonology, St. Petersburg, Russian Federation

Russian Federation

O. A. Manicheva

St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg, Russian Federation

Email: fake@neicon.ru

PhD, MD (Biology), Leading Researcher of St. Petersburg Research Institute Phthisiopulmonology, St. Petersburg, Russian Federation

Russian Federation

P. K. Yablonskiy

St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg, Russian Federation

Email: fake@neicon.ru

PhD, MD (Medicine), Professor, Director of St. Petersburg Research Institute Phthisiopulmonology, St. Petersburg, Russian Federation

Russian Federation

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