АПОПТОЗ И ИНФЕКЦИОННЫЕ БОЛЕЗНИ

Обложка
  • Авторы: Сомова Л.М.1, Беседнова Н.Н.2, Плехова Н.Г.2
  • Учреждения:
    1. ФГБУ НИИ эпидемиологии и микробиологии имени Г.П. Сомова СО РАМН, г. Владивосток, Россия 690087, Россия, г. Владивосток, ул. Сельская, 1, ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН. Тел./факс: 8 (423) 244-14-38
    2. ФГБУ НИИ эпидемиологии и микробиологии имени Г.П. Сомова СО РАМН, г. Владивосток, Россия
  • Выпуск: Том 4, № 4 (2014)
  • Страницы: 303-318
  • Раздел: ОБЗОРЫ
  • Дата подачи: 03.02.2015
  • Дата принятия к публикации: 03.02.2015
  • Дата публикации: 03.12.2014
  • URL: https://iimmun.ru/iimm/article/view/241
  • DOI: https://doi.org/10.15789/2220-7619-2014-4-303-318
  • ID: 241


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Аннотация

Апоптоз как иммуномодулирующая форма клеточной гибели играет стабилизирующую роль в поддержании оптимального количества клеток в организме. Биологическая сущность гибели клеток при инфекционной патологии освещена недостаточно, а понятие об отрицательном и положительном значении апоптоза в патогенезе болезней представлено неоднозначно. В обзоре основное внимание сосредоточено на классичес ком каспаза-зависимом апоптозе клеток врожденного и адаптивного иммунитета, реактивность которых связана c инициацией и исходом инфекционных процессов. Ряд возбудителей бактериальных и вирусных инфекций способны быть триггерами или ингибиторами апоптоза в эукариотической клетке хозяина, избегая действия факторов иммунной системы. При тяжелых инфекциях, протекающих с развитием сепсиса, фатальное значение имеет массивная апоптотическая потеря лимфоцитов в органах иммунной системы, что приводит к иммунодефицитному состоянию и у многих пациентов соответствует премортальному уменьшению циркулирующих лимфоцитов. Дальнейшие исследования по идентификации молекулярных элементов, с помощью которых патогенные агенты вызывают клеточную гибель, обеспечат разработку новых терапевтических подходов, включая ингибирование апоптоза, для предотвращения прогрессирования тяжелых инфекций.

Об авторах

Л. М. Сомова

ФГБУ НИИ эпидемиологии и микробиологии имени Г.П. Сомова СО РАМН, г. Владивосток, Россия 690087, Россия, г. Владивосток, ул. Сельская, 1, ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН. Тел./факс: 8 (423) 244-14-38

Автор, ответственный за переписку.
Email: l_somova@mail.ru

д.м.н., профессор, директор ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН, г. Владивосток, Россия

Россия

Н. Н. Беседнова

ФГБУ НИИ эпидемиологии и микробиологии имени Г.П. Сомова СО РАМН, г. Владивосток, Россия

Email: fake@neicon.ru

д.м.н., академик РАН, ведущий научный сотрудник ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН, г. Владивосток, Россия

Россия

Н. Г. Плехова

ФГБУ НИИ эпидемиологии и микробиологии имени Г.П. Сомова СО РАМН, г. Владивосток, Россия

Email: fake@neicon.ru

д.б.н., зав. лабораторией клеточной биологии и патогистологии ФГБУ НИИЭМ им. Г.П. Сомова СО РАМН, г. Владивосток, Россия

Россия

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