THE FEATURES OF HUMORAL IMMUNE RESPONSE FOR ANTIGENS OF OPPORTUNISTIC MICROORGANISMS IN CASE OF PHARYNX TONSILS HYPERTROPHY IN INFANTS AND PRESCHOOL CHILDREN

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Abstract

Abstract. Features of IgG and IgE immune response for opportunistic microbes of pharynx biotope in children with pharyngeal lymphoid hypertrophy and recurrent acute respiratory infections have been studied (base group). The ob tained data were compared with similar results for healthy children. It was shown that in children of base group in biotope of pharynx prevailed S. pyogenes, S. pneumoniae, S. mutans, P. vulgaris and C. albicans. It was demonstarted that in children of base group the IgG immune response was mainly induced by S. pyogenes, S. pneumoniae, B. catharrhalis and H. influenzae; and the IgE immune response — by S. pyogenes, S. pneumoniae, S. aureus and H. influenzae. The role of polyclonal induction of immune response to S. pneumoniae in pathogenesis of pharyngeal lymphoid hypertrophy and recurrent acute respiratory infections in children of early and preschool age has been detected. 

About the authors

E. V. Shabaldina

Federal State Budgetary Educational Institution of the highest vocational training Kemerovo State Medical Academy
of Ministry of Health of Russia

Email: weit2007@yandex.ru
PhD (Medicine), Associate Professor, Chief, Department of Otorhinolaryngology and Clinical Immunology Russian Federation

A. V. Shabaldin

Federal State Budgetary Educational Institution of the highest vocational training Kemerovo State Medical Academy
of Ministry of Health of Russia;
Federal State Budgetary Institution «Research Institute for Complex Issues of Cardiovascular Diseases» under
the Siberian Branch of the Russian Academy of Medical Sciences

Author for correspondence.
Email: weit2007@yandex.ru

PhD, MD (Medicine), Assistant Professor, Department of Otorhinolaryngology and Clinical Immunology, Kemerovo State Medical Academy; Leading Research Associate, Department of an Experimental and Clinical Cardiology, Research Institute for Complex Issues 
of Cardiovascular Diseases, RAMS, Siberian Branch

650029, Russian Federation, Kemerovo, Voroshilova str., 22а

Russian Federation

G. V. Lisachenko

Federal State Budgetary Educational Institution of the highest vocational training Kemerovo State Medical Academy
of Ministry of Health of Russia

Email: weit2007@yandex.ru
PhD, MD (Medicine), Professor, Department of Pathophysiology Russian Federation

M. V. Drozdova

Saint-Petersburg Research Institute of Ear, Throat, Nose and Speech the Ministry of Health of Russia

Email: weit2007@yandex.ru
PhD, MD (Medicine), Chief, Children’s Otorhinolaryngology Department Russian Federation

S. V. Riazantsev

Saint-Petersburg Research Institute of Ear, Throat, Nose and Speech the Ministry of Health of Russia

Email: weit2007@yandex.ru
PhD, MD (Medicine), Professor, Deputy Director Russian Federation

A. S. Simbirtsev

Saint-Petersburg State Federal Scientific Research Institute of especially pure biological products of Federal Medical Biological agency

Email: weit2007@yandex.ru
PhD, MD (Medicine), Professor, Director Russian Federation

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Copyright (c) 2014 Shabaldina E.V., Shabaldin A.V., Lisachenko G.V., Drozdova M.V., Riazantsev S.V., Simbirtsev A.S.

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