Comparison of the Level of Vitamin D in Preterm Infected and Uninfected Infants
- Authors: Boskabadi H., Zakerihamidi M., Faramarzi R.
- Section: ORIGINAL ARTICLES
- URL: https://iimmun.ru/iimm/article/view/8050
- DOI: https://doi.org/10.15789/2220-7619-COT-8050
- ID: 8050
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Abstract
Introduction: Despite the substantial progress in intensive cares, sepsis is still an important cause of neonatal mortality. Given the role of vitamin D in infection control; therfore, this study was conducted to compare vitamin D level in infected and uninfected preterm infants.
Materials and Methods: This cross-sectional study was carried out on 87 preterm infants(45 infected infants and 42 uninfected infants) hospitalized in Mashhad Ghaem Hospital,Iran, during 2015-2017. . The subjects were selected by using convenience sampling. . The infected infants (n=45) included babies with clinical and laboratory findings compatible with infection and/or positive blood or cerebrospinal fluid cultures. The serum levels vitamin D were measured in all infants. A researcher-made questionnaire containing demographic, clinical and laboratory features of infants was used. In addition, independent t-test and chi-square test were applied. SPSS was used to perform the statistical data analysis. .
Results: 83% of infants had Vitamin D deficiency 34.5%, 26.4%, and 21.8% of whom exhibited severe (less than 10ngml), moderate (10.1-20ngml), mild deficiency (20.1-30ngml), respectively. The mean vitamin D level of infants was 23.31±9.40ng/ml in the control group and 11.02±8.64ng/ml in the case group (P=0.000). In the case group, the mean vitamin D was 8.14±5.53ngml in early sepsis and 12.62±9.75ngml in late-onset sepsis (P=0.121). 95% of infected infants and 71% of uninfected infants had vitamin D less than 30ngml (P=0.003).
Conclusion: Vitamin D deficiency is very common in preterm infants. Serum vitamin D levels in infants with sepsis were lower than those in uninfected infants. Therefore, the correction of Vitamin D deficiency may contribute to better control of neonatal infection.
Keywords
About the authors
Hassan Boskabadi
Email: boskabadih@mums.ac.ir
Maryam Zakerihamidi
Email: maryamzakerihamidi@yahoo.co.nz
Iran, Islamic Republic of
Raheleh Faramarzi
Author for correspondence.
Email: faramarzir@mums.ac.ir
References
- Alves, F. S., Freitas, F. G. R., Bafi, A. T., Azevedo, L. C. P., Machadom F. R. 2015. Serum concentrations of vitamin D and organ dysfunction in patients with severe sepsis and septic shock. Rev. Bras. Ter. Intensiva., 27, 4, 376-377.
- Aydemir, G., Cekmez, F., Kalkan, G., Fidanci, MK., Kaya, G., Karaoglu, A., Meral, C., Arzıman, İ., Karademir, F., Ayar, G., Gunduz, RC. 2014. High serum 25-hydroxyvitamin D levels are associated with pediatric sepsis. Tohoku. J. Exp. Med., 234, 4, 295-298.
- Aydogmus, S. Kelekci, S. Aydogmus, H. Eriş, S. Desdicioğlu, R. Yilmaz, B. Sağlam, G. 2015. High prevalence of vitamin D deficiency among pregnant women in a Turkish population and impact on perinatal outcomes. The Journal of Maternal-Fetal & Neonatal Medicine., 13, 28(15), 1828-32.
- Baeke, F., Takiishi, T., Korf H., Gysemans, C., Mathieu, C. 2010. Vitamin D: modulator of the immune system. Curr. Opin. Pharmacol., 10, 4, 482-496.
- Belderbos, ME. Houben, ML. Wilbrink, B. Lentjes, E. Bloemen, EM. Kimpen, JL. Rovers, M. Bont L. 2011. Cord blood vitamin D deficiency is associated with respiratory syncytial virus bronchiolitis. Pediatr., 127, 6, e1513-e1520.
- Boskabadi H, Zakerihamidi M. Evaluate the diagnosis of neonatal sepsis by measuring interleukins: A systematic review. Pediatrics & Neonatology. 2018;59(4):329-38.
- Boskabadi, H. Moudi, A.,Parvini, Z. Barati, T. 2012. Evaluation of the cause and related factors of neonatal mortality in Qaem hospital 1388-89. Iran. J. Obstet. Gynecol. Infertil., 14, 7,21-6.
- Boskabadi, H. Maamouri, G. Kalani-Moghaddam, F. Nakhaei, MHA. Zakerihamidi, M. Rakhshanizadeh, F. 2020. Comparison of umbilical cord serum vitamin D levels between infants with transient tachypnea of the newborn and those without respiratory distress. Arch Iran Med.,23(8), 530-5.
- Boskabadi, H. Moradi, A. Zakerihamidi, M. 2022. Evaluation of maternal and infantile levels of vitamin D in preterm infants. Curr Pediatr Rev., 18(1), 47-52.
- Boskabadi, H. Rakhshanizadeh, F. Maryam, Z. 2022. Comparison of vitamin D levels between mothers and infants with and without prolonged membrane rupture. Инфекция и иммунитет, 2(3), 556-62.
- Cameron, C. Dallaire, F. Vézina, C. Muckle, G. Bruneau, S. Ayotte, P. Dewailly, E. 2008. Neonatal vitamin A deficiency and its impact on acute respiratory infections among preschool Inuit children. Can. J. Public. Health., 99,2,102-106.
- Cetinkaya, M. Cekmez, F. Buyukkale, G. Erener-Ercan, T. Demir, FE. Tunc, T. Aydın, FN. Aydemir, G. 2015. Lower vitamin D levels are associated with increased risk of early-onset neonatal sepsis in term infants. J. Perinatol., 35, 1, 39-45.
- Choi, R. Kim, S. Yoo, H. Cho, YY. Kim, SW. Chung, JH. Oh, SY. Lee, SY. 2015. High prevalence of vitamin D deficiency in pregnant Korean women: the first trimester and the winter season as risk factors for vitamin D deficiency. Nutrients., 7,5,3427-3448.
- Clancy, N. Onwuneme, C. Carroll, A. McCarthy, R. , MJ. Murphy, N. Molloy, EJ. 2013. Vitamin D and neonatal immune function. J. Matern. Fetal. Neonatal. Med., 26, 7,639-646.
- Delrue, C. Speeckaert, R. Delanghe, JR. Speeckaert, MM. 2023. Vitamin D Deficiency: An Underestimated Factor in Sepsis?. Int. J. Mol. Sci., 2, 24(3):2924-2925.
- Ginde, A. A. Camargo, Jr C. A. Shapiro, N. I. 2011. Vitamin D insufficiency and sepsis severity in emergency department patients with suspected infection. Acad. Emerg. Med., 18, 5,551-554.
- Holick, M. F. 2007. Vitamin D deficiency. N. Engl. J. Med., 357,3,266-281.
- Hwalla, N. Al Dhaheri, AS. Radwan, H. Alfawaz, HA. Fouda, MA. Al-Daghri, NM. Zaghloul, S. Blumberg, JB. 2017. The Prevalence of Micronutrient Deficiencies and Inadequacies in the Middle East and Approaches to Interventions. Nutrients., 3,9(3):229.
- Javadi-Nia, S. Noorbakhsh, S. Izadi, A. Shokrollahi, M. R. Asgarian, R. Tabatabaei, A. 2014. Vitamin A, D and zinc serum levels in children with and without acute respiratory tract infection in two university hospitals. Tehran. University. Medical. Journal., 71,12.
- Kanth, S. Reddy, K. Abhishek, G. 2016. Association between vitamin D levels and early onset sepsis in infants: a prospective observational study. Int. J. Contemp. Pediatr., 3,4, 1189-1192.
- Karatekin, G. Kaya, A. , Ö. , H. Nuhoğlu, A. 2009. Association of subclinical vitamin D deficiency in newborns with acute lower respiratory infection and their mothers. Eur. J. Clin. Nutr., 63, 4, 473-477.
- Kempker, J. A. Han, J. E. Tangpricha V. Ziegler, T. R. Martin, G. S. 2012. Vitamin D and sepsis: an emerging relationship. Dermatoendocrinol., 4,2,101-108.
- Lee, CJ. Buznyk, O. Kuffova, L. Rajendran, V. Forrester, JV. Phopase, J. Islam, MM. Skog, M. Ahlqvist, J. Griffith, M. 2014. Cathelicidin LL-37 and HSV-1 corneal infection: peptide versus gene therapy. Transl. Vis. Sci. Technol., 3,3,4-4.
- Mookherjee, N.Rehaume, L. M. Hancock, R. E. 2007. Cathelicidins and functional analogues as antisepsis molecules. Expert. Opin. Ther. Targets., 11,8,993-1004.
- Nair, V. Soraisham, A. S. 2013. Probiotics and prebiotics: role in prevention of nosocomial sepsis in preterm infants. Int. J. Pediatr., 2013.
- Nelson, C. D. Reinhardt, T. A. Beitz, D. C. Lippolis, J. D. 2010. In vivo activation of the intracrine vitamin D pathway in innate immune cells and mammary tissue during a bacterial infection. PLoS. One., 5, 11.
- Nijnik, A. Hancock, R. E. 2009. The roles of cathelicidin LL-37 in immune defences and novel clinical applications. Curr. Opin. Hematol., 16, 1, 41-47.
- Park, S.-H. Lee, G.-M. Moon, J.-E. Kim, H.-M. 2015. Severe vitamin D deficiency in preterm infants: maternal and neonatal clinical features. Korean. J. Pediatr., 58, 11, 427-428.
- Pourbadakhshan, N. Boskabadi, H. Nakhaei, MHA. Darabi, A. Sani, MR. 2023. The Effect of Maternal Vitamin D Intake on the Incidence of Nonspecific Respiratory Distress in Infants: A Randomized Clinical Trial. Clinical and Experimental Obstetrics & Gynecology.,50(4),78.
- Rech, M. A. Hunsaker, T. Rodriguez, J. 2014. Deficiency in 25-hydroxyvitamin D and 30-day mortality in patients with severe sepsis and septic shock. Am. J. Crit. Care., 23, 5, e72-e79.
- Schroth, R. J. Lavelle, C. Tate, R. Bruce, S. Billings, R. J. Moffatt, M. E. 2014. Prenatal vitamin D and dental caries in infants. Pediatr., 133, 5, e1277-e1284.
- Shah, S. S. H. Saleem, M. Mehmood, T. Ahmed, T. 2015. Frequency and outcome of necrotizing enterocolitis in preterm neonates. J. Ayub. Med. Coll. Abbottabad., 27, 1,85-87.
- Singh, G. Singh, G. Brar, H. Malik, S. 2016. Vitamin D levels in preterm and term neonates at birth. Int. J. Contemp. Pediatr., 4, 1, 48-52.
- Sivanandan, S. Soraisham, A. S. Swarnam, K. 2011. Choice and duration of antimicrobial therapy for neonatal sepsis and meningitis. Int. J. Pediatr., 2011.
- Sun, J. Zhang, YG. 2022. Vitamin D Receptor Influences Intestinal Barriers in Health and Disease. Cells., 27,11(7), 1129.
- Watkins, R. R. Yamshchikov, A. V. Lemonovich, T. L. Salata, R. A. 2011. The role of vitamin D deficiency in sepsis and potential therapeutic implications. J. Infect., 63, 5, 321-326.
- Workneh, Bitew Z. Worku, T. Alemu A. 2020. Effects of vitamin D on neonatal sepsis: A systematic review and meta-analysis. Food. Sci. Nutr., 10, 9(1):375-388.
- Delrue, C. Speeckaert, R. Delanghe, JR. Speeckaert, MM. 2023. Vitamin D Deficiency: An Underestimated Factor in Sepsis?. Int. J. Mol. Sci., 2, 24(3):2924-2925.
- Zisi, D. Challa, A. Makis, A. 2019. The association between vitamin D status and infectious diseases of the respiratory system in infancy and childhood. Hormones, 18, 353–363.
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