Comparison of the Level of Vitamin D in Preterm Infected and Uninfected Infants


Introduction: Despite the substantial progress in intensive cares, sepsis is still an  important cause of neonatal  mortality. Given the role of vitamin D in infection control; therfore,  this study was conducted to compare vitamin D level in infected and uninfected preterm infants.

Materials and Methods: This cross-sectional study was carried out on 87 preterm infants(45 infected infants and 42 uninfected infants) hospitalized in Mashhad Ghaem Hospital,Iran, during  2015-2017.  . The subjects were  selected by  using convenience sampling. . The infected infants (n=45) included babies with clinical and laboratory findings compatible with infection and/or positive blood or cerebrospinal fluid cultures.  The serum levels vitamin D were measured in  all infants. A researcher-made questionnaire containing demographic, clinical and laboratory features of infants was used. In addition, independent t-test and  chi-square test  were applied. SPSS  was used to perform the statistical data analysis. .

Results: 83% of infants had Vitamin D deficiency  34.5%, 26.4%, and 21.8% of whom exhibited  severe (less than 10ngml), moderate (10.1-20ngml), mild deficiency (20.1-30ngml), respectively. The mean vitamin D level  of infants was 23.31±9.40ng/ml in the control group and 11.02±8.64ng/ml in the case group (P=0.000). In the case group, the mean vitamin D was 8.14±5.53ngml in early sepsis and 12.62±9.75ngml in late-onset sepsis (P=0.121). 95% of infected infants and 71% of uninfected infants had vitamin D less than 30ngml (P=0.003).

Conclusion: Vitamin D deficiency is very common in preterm infants. Serum vitamin D levels in infants with sepsis  were lower  than those  in uninfected infants. Therefore,  the correction  of Vitamin D deficiency may  contribute to  better control of neonatal infection.

About the authors

Hassan Boskabadi


Maryam Zakerihamidi

Iran, Islamic Republic of

Raheleh Faramarzi

Author for correspondence.


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