Russian Journal of Infection and ImmunityRussian Journal of Infection and ImmunityИнфекция и иммунитет2220-76192313-7398SPb RAACI805010.15789/2220-7619-COT-8050ORIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИResearch ArticleComparison of the level of vitamin D in preterm infected and uninfected infantsСравнение уровня витамина D у недоношенных инфицированных и неинфицированных новорожденныхZakerihamidiMaryamЗакерихамидиМарьям
Iran, Islamic Republic of

Associate Professor of Reproductive Health, Department of Midwifery, School of Medical Sciences

доктор философии (репродуктивное здоровье), доцент кафедры репродуктивного здоровья кафедры акушерства факультета медицинских наук

maryamzakerihamidi@yahoo.co.nzBoskabadiHassanБоскабадиХасан
Iran, Islamic Republic of

Professor, Department of Pediatrics, Faculty of Medicine

профессор кафедры педиатрии, факультет медицины

boskabadih@mums.ac.irFaramarziRahelehФарамарзиРахеле
Iran, Islamic Republic of

Assistant Professor, Department of Pediatrics, Faculty of Medicine

доцент кафедры педиатрии, факультет медицины

faramarzir@mums.ac.irMashhad University of Medical SciencesМешхедский университет медицинских наук03072023241020231347547601903202323062023Copyright ©; 2023, Zakerihamidi M., Boskabadi H., Faramarzi R.Copyright ©; 2023, Закерихамиди М., Боскабади Х., Фарамарзи Р.2023Zakerihamidi M., Boskabadi H., Faramarzi R.Закерихамиди М., Боскабади Х., Фарамарзи Р.https://creativecommons.org/licenses/by/4.0https://iimmun.ru/iimm/article/view/8050

Introduction. Despite the substantial progress in intensive cares, sepsis is still an important cause of neonatal mortality. Given the role of vitamin D in infection control, this study was conducted to compare vitamin D level in infected and uninfected preterm infants. Materials and methods. This cross-sectional study was carried out on 87 preterm infants (45 infected infants and 42 uninfected infants) hospitalized in Mashhad Ghaem Hospital, Iran, during 2015–2017. The subjects were selected by using convenience sampling. The infected infants (n = 45) included babies with clinical and laboratory findings compatible with infection and/or positive blood or cerebrospinal fluid cultures. The serum levels vitamin D were measured in all infants. A researcher-made questionnaire containing demographic, clinical and laboratory features of infants was used. In addition, independent t-test and chi-square test were applied. SPSS was used to perform the statistical data analysis. Results. 83% of infants had vitamin D deficiency 34.5%, 26.4%, and 21.8% of whom exhibited severe (less than 10 ng/ml), moderate (10.1–20 ng/ml), mild deficiency (20.1–30 ng/ml), respectively. The mean vitamin D level of infants was 23.31±9.40 ng/ml in the control group and 11.02±8.64 ng/ml in the case group (p = 0.000). In the case group, the mean vitamin D was 8.14±5.53 ng/ml in early sepsis and 12.62±9.75 ng/ml in late-onset sepsis (p = 0.121). 95% of infected infants and 71% of uninfected infants had vitamin D less than 30 ng/ml (p = 0.003). Conclusion. Vitamin D deficiency is very common in preterm infants. Serum vitamin D levels in infants with sepsis were lower than those in uninfected infants. Therefore, the correction of vitamin D deficiency may contribute to better control of neonatal infection.

Введение. Несмотря на значительный прогресс в области интенсивной терапии, сепсис по-прежнему остается одной из основных причин неонатальной смертности. Поскольку уровень витамина D влияет на тяжесть течения инфекций, в настоящем исследовании было проведено сравнение уровня витамина D у инфицированных и неинфицированных недоношенных детей.

Материалы и методы. Проведено поперечное исследование 87 недоношенных новорожденных (45 инфицированных и 42 неинфицированных младенца), госпитализированных в больницу Мешхед Гаем, Иран, в период с 2015 по 2017 г. Отбор пациентов осуществлялся методом случайной выборки. В группу инфицированных (n = 45) были включены младенцы с клиническими и лабораторными данными, соответствующими инфекции, и/или положительными высевами крови или спинномозговой жидкости. Уровни витамина D в сыворотке крови определяли у всех младенцев. Была использована разработанная нами анкета, содержащая демографические, клинические и лабораторные данные младенцев. Cтатистическая обработка данных проводилась в программе SPSS и включала оценку независимого t-критерия и критерия хи-квадрат.

Результаты. У 83% младенцев был выявлен дефицит витамина D, при этом у 34,5, 26,4 и 21,8% установлена тяжелая (менее 10 нг/мл), умеренная (10,1–20 нг/мл) и легкая степень дефицита (20,1–30 нг/мл) соответственно. Средний уровень содержания витамина D у младенцев составил 23,31±9,40 нг/мл в контрольной группе и 11,02±8,64 нг/мл в основной (p = 0,000). При раннем и позднем сепсисе в основной группе средний уровень витамина D составил 8,14±5,53 и 12,62±9,75 нг/мл (p = 0,121) соответственно. У 95% инфицированных и 71% неинфицированных младенцев уровень витамина D был менее 30 нг/мл (p = 0,003).

Выводы. Дефицит витамина D встречается у недоношенных детей довольно часто. Уровень витамина D в сыворотке крови у недоношенных новорожденных с сепсисом был ниже, чем у неинфицированных. Следовательно, коррекция дефицита витамина D может препятствовать развитию тяжелых форм неонатальной инфекции.

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