FEATURES OF THE MICROBIOME OF THE UPPER RESPIRATORY TRACT IN CHILDREN WITH RECURRENT RESPIRATORY DISEASES

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Abstract

Studies of the metagenome of the upper respiratory tract in children showed the presence of five major bacterial phyla: Proteobacteria, Firmicutes, Bacteroidetes, Actinobacteria and Fusobacteria. Were revealed population differences in the distribution of weights of the above listed phyla, but subject to the dominance of the Firmicutes. Proved the role of environmental factors and time of year for representation in these biotopes of the phyla: Firmicutes, Proteobacteria, Bacteroidetes. Recurrent respiratory infections, hypertrophy of the tonsils of the lymphoid pharyngeal ring, secretory middle ear infections in children is associated with carriage of Haemophilus (H.) parainfluenzae, H. paraphrohaemolyticus, Gemella (G.) haemolysans, G. morbillorum, G. sanguinis, Streptococcus (S.) pneumoniae, S. pseudopneumoniae, S. intermedius, S. agalactiae.

 

About the authors

A. V. Shabaldin

Kemerovo State Medical Academy of Ministry of Health of Russia, Kemerovo;
Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo

Author for correspondence.
Email: weit2007@ya.ru
PhD, MD (Medicine), Leading Researcher, Laboratory of Cell Technologies, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation; Professor of Department of Otolaryngology and Clinical Immunology, Kemerovo State Medical Academy Russian Federation

E. V. Shabaldina

Kemerovo State Medical Academy of Ministry of Health of Russia, Kemerovo

Email: weit2007@ya.ru
PhD, MD (Medicine), Associate Professor, Head of the Department of Otorhinolaryngology and Clinical Immunology, Kemerovo State Medical Academy Russian Federation

A. S. Simbirtsev

State Research Institute of Highly Pure Biopreparations FMBA of Russia, St. Petersburg

Email: weit2007@ya.ru
RAS Corresponding Member, PhD, MD (Biology), Professor, Deputy Director on Science of State Research Institute of Highly Pure Biopreparations Russian Federation

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