MEASLES VIRUS IMMUNITY LEVEL STUDY IN PARTICULAR POPULATION GROUPS OF THE REPUBLIC OF GUINEA WITHIN THE FRAMEWORK OF GLOBAL MEASLES ELIMINATION PROGRAM. REPORT 1
- Authors: Popova A.Y.1, Bichurina M.A.2, Lavrentyeva I.N.2, Zheleznova N.V.2, Antipova A.Y.2, Shcherbakova S.A.3, Boiro M.Y.4, Totolian A.A.2
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Affiliations:
- Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor), Mosсow, Russian Federation
- St. Petersburg Pasteur Institute, St. Petersburg, Russian Federation
- Russian Scientific and Research Antiplague Insititute “Mikrob”, Saratov, Russian Federation
- Institute of Applied Biology in Guinea, Kindia, Republic of Guinea
- Issue: Vol 6, No 4 (2016)
- Pages: 353-358
- Section: ORIGINAL ARTICLES
- Submitted: 05.01.2017
- Accepted: 05.01.2017
- Published: 06.12.2016
- URL: https://iimmun.ru/iimm/article/view/447
- DOI: https://doi.org/10.15789/2220-7619-2016-4-353-358
- ID: 447
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Abstract
Measles remains one of the main reasons for child mortality in developing countries and periodically leads to the emergence of large outbreaks in different countries. This problem became especially urgent after WHO accepted the strategic plan to fight against measles. The plan has set the goal to decrease measles on a global scale. In 2010–2011 the large outbreaks of measles were registered on the African continent: in the Democratic Republic of Congo in the south of Africa, in Nigeria and in some other African countries. In the Republic of Guinea vaccination against measles is carried out singly to children aged 9 months. In 2014–2015 the increase of measles incidence was noted. Materials and methods. Using ELISA 22 blood serum samples of healthy adult Guineans aged 24–71 and 136 blood serum samples received from children and adults — the patients of hospital in the town of Kindi (Republic of Guinea) have been examined. The clinical samples were received in 2015–2016. The following test systems were used: the test systems produced by Euroimmun Medizinische Labordiagnostika AG (Germany): «Anti-Measles Virus ELISA (IGM)», «Anti-Measles Virus ELISA (IgG)»; «Avidity: Anti-Measles Virus ELISA (IgG)», and also ELISA Vector-Best IgM-measles test system (Russia). Results and discussion. Only one out of 22 examined healthy individuals hasn’t revealed IgG-antibodies to measles virus. The quantitative titre test of IgG-antibodies, and also their avidity among other 21 individuals testify experiencing measles in the recent or remote past. Having examined 116 blood serum samples of hospital patients in Kindi for IgM-measles-antibodies, the measles case with a 2.5-year-old child has been retrospectively revealed. Having examined 130 blood serum samples for IgG-antibodies to measles virus, 12.3% of seronegative to measles individuals have been revealed. All examined individuals aged 23 and older were seropositive to measles virus, and 60% of them had high antibody titres. The antibodies to measles virus were absent or were defined in low titres among 76.2% of people under 22, which can demonstrate violations of planned child vaccination due to the Ebola outbreak. In order to decrease the risk of emergence of large measles outbreaks in the areas, free from Ebola virus transmission, WHO recommends to conduct mass anti-measles vaccination campaigns.
About the authors
A. Yu. Popova
Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor), Mosсow, Russian Federation
Author for correspondence.
Email: pasteur.lawr@mail.ru
Chief State Sanitary Physician of the Russian Federation, Head of Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor)
РоссияM. A. Bichurina
St. Petersburg Pasteur Institute, St. Petersburg, Russian Federation
Email: pasteur.lawr@mail.ru
PhD, MD (Medicine), Head of the Virology Laboratory by Elimination Measles and Rubella
РоссияI. N. Lavrentyeva
St. Petersburg Pasteur Institute, St. Petersburg, Russian Federation
Email: pasteur.lawr@mail.ru
PhD, MD (Medicine), Head of the Laboratory of Experimental Virology
РоссияN. V. Zheleznova
St. Petersburg Pasteur Institute, St. Petersburg, Russian Federation
Email: pasteur.lawr@mail.ru
PhD (Biology), Leading Reseacher, Laboratory of Viral Hepatitis
РоссияA. Yu. Antipova
St. Petersburg Pasteur Institute, St. Petersburg, Russian Federation
Email: pasteur.lawr@mail.ru
PhD (Biology), Researcher, Laboratory of Experimental Virology
РоссияS. A. Shcherbakova
Russian Scientific and Research Antiplague Insititute “Mikrob”, Saratov, Russian Federation
Email: pasteur.lawr@mail.ru
hD, MD (Biology), Deputy Director for Scientific and Experimental Work, Federal State Institute of Healthcare, Russian Scientific and Research Antiplague Insititute “Mikrob”
РоссияM. Y. Boiro
Institute of Applied Biology in Guinea, Kindia, Republic of Guinea
Email: pasteur.lawr@mail.ru
Professor, General Director, Institute of Applied Biology in Guinea
ГвинеяA. A. Totolian
St. Petersburg Pasteur Institute, St. Petersburg, Russian Federation
Email: pasteur.lawr@mail.ru
RAS Full Member, PhD, MD (Medicine), Professor, Head of the Laboratory of Molecular Immunology, Director of St. Petersburg Pasteur Institute
РоссияReferences
- Бичурина М.А., Железнова Н.В., Лялина Л.В., Антипова А.Ю., Тимофеева Е.В. Успехи и проблемы на этапе сертификации территорий Северо-Западного федерального округа на отсутствие эндемичной кори // Инфекция и иммунитет. 2012. Т. 2, № 1–2. С. 503–504. [Bichurina M.A., Zheleznova N.V., Lyalina L.V., Antipova A.Yu., Timofeeva E.V. Successes and challenges in the process of certifying areas of the North-Western federal district for the absence of endemic meas les. Infektsiya i immunitet = Russian Journal of Infection and Immunity, 2012, vol. 2, no. 1–2, pp. 503–504. (In Russ.)]
- Бичурина М.А., Тимофеева Е.В., Железнова Н.В., Игнатьева Н.А., Шульга С.В., Лялина Л.В., Дегтярев О.В. Вспышка кори в детской больнице Санкт-Петербурга в 2012 году // Журнал инфектологии. 2013. Т. 5, № 2. С. 96–102. [Bichurina M.A., Timofeeva E.V., Zheleznova N.V., Ignatieva N.A., Shulga S.V., Lyalina L.V., Degtyarev O.V. Measles outbreak in the Children’s Hospital in Saint-Petersburg, 2012. Zhurnal infektologii = Journal of Infectology, 2013, vol. 5, no. 2, pp. 96–102. (In Russ.)]
- Национальная программа элиминации кори к 2010 году. Приказ МЗ РФ № 270 от 19.08.2002. [National programme for the elimination of measles by 2010. Ministry of health order No. 270 (19.08.2002).]
- Онищенко Г.Г., Ежлова Е.Б., Лазикова Г.Ф., Мельникова А.А., Ватолина А.А., Тихонова Н.Т., Герасимова А.Г. Реализация программы ликвидации кори в Российской Федерации // Журнал микробиологии, эпидемиологии и иммунобиологии. 2011. № 4. С. 51–56. [Onischenko G.G., Ezhlova E.B., Lazikova G.F., Melnikova A.A., Vatolina A.A., Tikhonova N.T., Gerasimova A.G. Implementation of measles elimination program in Russian Federation. Zhurnal mikrobiologii, epidemiologii i immunobiologii = Journal of Microbiology Epidemiology and Immunobiology, 2011, no. 4, pp. 51–56. (In Russ.)]
- Тихонова Н.Т., Ежова Е.Б., Герасимова А.Г., Цвиркун О.В., Мамаева Т.А., Наумова М.А. Проблемы элиминации кори в Российской Федерации // Инфекция и иммунитет. 2012. Т. 2, № 1–2. С. 522–523. [Problems of measles elimination in the Russian Federation. Infektsiya i immunitet = Russian Journal of Infection and Immunity, 2012, vol. 2, no. 1–2, pp. 522–523. (In Russ.)]
- Элиминация кори и краснухи и предупреждение врожденной краснушной инфекции. Стратегический план Европейского региона ВОЗ 2005–2010 гг. ВОЗ, 2005. 31 с. [Eliminatsiya kori i krasnukhi i preduprezhdenie vrozhdennoi krasnushnoi infektsii. Strategicheskii plan Evropeiskogo regiona VOZ 2005–2010 gg. [Eliminating measles and rubella and preventing congenital rubella infection: WHO European Region strategic plan 2005–2010]. WHO, 2005. 31 p.]
- CDC. Measles outbreak. Hennepin County, Minnesota MMWR Weekly. 2011, vol. 60, no. 13, p. 421.
- Global distribution of the measles and rubella genotypes – update. Wkly Epidemiol. Rec., 2006, vol. 81, pp. 469–480.
- Kutty P., Rota J., Bellini W., Redd S.B., Barskey A., Wallace G. CDC. Manual for the surveillance of vaccine-preventable diseases. May 20, 2011.
- WHO vaccine-preventable diseases: monitoring system. 2016 global summary. URL: http://apps.who.int/immunization_monitoring/ globalsummary/countries?countrycriteria%5Bcountry%5D%5B%5D=RUS (10 october 2016)