CLINICAL AND VIROLOGICAL CHARACTERISTICS OF DISEASES ASSOCIATED WITH THE KAPOSI SARCOMA VIRUS

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Abstract

Abstract. The paper presents literature data and results of own studies on the Kaposi's sarcoma herpesvirus (KSHV) and its association with Kaposi's sarcoma (KS), the primary effusion lymphoma (PEL) and multicentric Kastleman disease (MCD). The obtained data show that all 3 main clinical forms of KS, diagnosed in Russia, are significantly associated with KSHV, though not always in 100% of cases. Distinct groups of persons with high prevalence of virus infection have been detected among patients with other forms of cancer and non-cancer diseases that may represent a risk factor for development of KS. It was found that the prostate, especially in patients with carcinoma of the prostate and KS could be an important localization of virus and intimate contact with these patients should be limited. For the first time in Russia HIV-negative case of PEL associated with KSHV had been diagnosed and studied in details. It was also demonstrated that isolates of KSHV, circulating in the country, belong to the two major genetic subgroups of the virus (A and C), a widely represented in the European countries and in the United States, which indicates a common origin of the virus in these countries. The current methodologies of KS’ treatment are also presented.

About the authors

V. E. Gurtsevich

ГУ Российский онкологический научный центр им. Н.Н. Блохина РАМН, Москва

Author for correspondence.
Email: gurtsevitch@crc.umos.ru

д.м.н., профессор, зав. лабораторией вирусного канцерогенеза

115478, Москва, Каширское ш., 24

Russian Federation

L. S. Yakovleva

ГУ Российский онкологический научный центр им. Н.Н. Блохина РАМН, Москва

Email: gurtsevitch@crc.umos.ru
Russian Federation

S. A. Galetskiy

ГУ Российский онкологический научный центр им. Н.Н. Блохина РАМН, Москва

Email: gurtsevitch@crc.umos.ru
Russian Federation

T. A. Afanasieva

ГУ Российский онкологический научный центр им. Н.Н. Блохина РАМН, Москва

Email: gurtsevitch@crc.umos.ru
Russian Federation

N. B. Senjuta

ГУ Российский онкологический научный центр им. Н.Н. Блохина РАМН, Москва

Email: gurtsevitch@crc.umos.ru
Russian Federation

V. N. Stepina

ГУ Российский онкологический научный центр им. Н.Н. Блохина РАМН, Москва

Email: gurtsevitch@crc.umos.ru
Russian Federation

E. L. Kadyrova

ГУ Российский онкологический научный центр им. Н.Н. Блохина РАМН, Москва

Email: gurtsevitch@crc.umos.ru
Russian Federation

D. A. Shirokov

ГУ Российский онкологический научный центр им. Н.Н. Блохина РАМН, Москва

Email: gurtsevitch@crc.umos.ru
Russian Federation

M. M. Anokhina

ГУ Российский онкологический научный центр им. Н.Н. Блохина РАМН, Москва

Email: gurtsevitch@crc.umos.ru
Russian Federation

T. T Kondratieva

ГУ Российский онкологический научный центр им. Н.Н. Блохина РАМН, Москва

Email: gurtsevitch@crc.umos.ru
Russian Federation

N. N. Tupitsin

ГУ Российский онкологический научный центр им. Н.Н. Блохина РАМН, Москва

Email: gurtsevitch@crc.umos.ru
Russian Federation

A. Zhessan

Институт Пастера, Париж

Email: gurtsevitch@crc.umos.ru
France

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Copyright (c) 2014 Gurtsevich V.E., Yakovleva L.S., Galetskiy S.A., Afanasieva T.A., Senjuta N.B., Stepina V.N., Kadyrova E.L., Shirokov D.A., Anokhina M.M., Kondratieva T.T., Tupitsin N.N., Zhessan A.

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