HIV INFECTION STAGE, ANTIRETROVIRAL THERAPY SCHEME AND PATIENT IMMUNE STATUS INFLUENCE ON HIV/TB CO-INFECTION OUTCOME

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Abstract

Retrospective research of 381 clinical records is conducted to study HIV infection influence on stationary stage of tuberculosis treatment outcome in HIV-TB co-infected patients. All cases were divided depending on a hospitalization outcome on favorable and adverse. At most of patients tuberculosis of respiratory organs met. Immunological researches were conducted, the stage of HIV infection was registered and the issue of purpose of anti-retroviral therapy was resolved. Besides, as indirect signs of an immunodeficiency at the patients with a combination of tuberculosis and HIV infection who were on hospitalization the indicators received when carrying out clinical laboratory trials were analyzed: absolute and relative quantity of lymphocytes according to the general blood test, the contents the globulin fractions and circulating immune complexes concentration according to the clinical chemistry blood test. At an assessment of results in both groups of research more than at a half of patients existence of HIV infection at late stages that speaks about late identification and neglect of an immunodeficiency was revealed. At patients with tuberculosis of lungs in combination with HIV infection at a failure statistically significant decrease in an immunoregulatory index is revealed. It is interesting that the level of CD4 lymphocytes and a stage of HIV infection had no impact on the co-infection’s outcome. However, existence of virus loa ding more than 100 000 copies/ml reduced probability favorable an outcome of treatment of tuberculosis at the patient with HIV infection. Timely purpose of anti-retroviral therapy at patients with co-infection increased chances of treatment of tuberculosis at patients with an immunodeficiency. Frequency of adverse side effect of antiviral therapy met equally often at patients in both groups. Thus, patients at any stages of HIV infection with any forms of tuberculosis, including generalized, had a chance to have a favorable outcome of a disease. We consider the reasonable recommendation about carrying out anti-retroviral therapy of patients by all with a combination of tuberculosis and HIV infection, irrespective of the HIV infection stage.

About the authors

A. V. Mordyk

Omsk State Medical University, Omsk, Russian Federation

Author for correspondence.
Email: amordik@mail.ru

PhD, MD (Medicine), Associate Professor, Head of Phthisiology and Phthisiosurgery Department, Omsk State Medical University, Omsk, Russian Federation 644050, Russian Federation, Omsk, Himikov str., 8A, Phone: +7 (3812) 40-45-15 (office)

Russian Federation

S. V. Sitnikova

Omsk State Medical University, Omsk, Russian Federation

Email: fake@neicon.ru

PhD Candidate, Phthisiology and Phtisiosurgery Department, Omsk State Medical University, Omsk, Russian Federation

Russian Federation

L. V. Puzyreva

Omsk State Medical University, Omsk, Russian Federation

Email: fake@neicon.ru

PhD (Medicine), Assistant Professor, Phthisiology and Phthisiosurgery Department, Omsk State Medical University, 
Omsk, Russian Federation

Russian Federation

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Copyright (c) 2016 Mordyk A.V., Sitnikova S.V., Puzyreva L.V.

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