ASSOCIATION OF TREM-1 GENE POLYMORPHISMS WITH INFECTIVE ENDOCARDITIS

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Abstract

Infective endocarditis (IE) is a septic inflammation of endocardium, which generally involves the lining of the heart chambers and heart valves. The development of IE depends in many respects on how properly and efficiently the immune system responds to the occurrence of an infection. Innate immunity, which carries out the response to a transient bacteremia, is genetically determined in a large extent. Pattern recognition receptors, which identify pathogenand danger-associated molecular patterns, are the main effectors of innate immune response; one of these receptors is triggering receptor expressed on myeloid cells-1 (TREM-1). We hypothesized that inherited variation in TREM-1 gene may affect individual susceptibility to IE. The distribution of genotypes and alleles of rs1817537, rs3804277, rs6910730, rs7768162, rs2234246, rs4711668, rs9471535, and rs2234237 gene polymorphisms was investigated in 110 Caucasian (Russian) subjects with IE and 300 age-, sex-, and ethnicity-matched healthy blood donors. Odds ratios with 95% confidence intervals were calculated. We found that rs1817537 polymorphism was associated with decreased IE risk (OR = 0.60; 95%CI = 0.37–0.99; р = 0.046, dominant model); however, this was not significant after an adjustment for multiple comparisons. Therefore, we observed no statistically significant association between the investigated polymorphisms within TREM-1 gene and IE. Further in-depth investigations in this field are necessary to shed the light on the impact of inherited variation within innate immune response genes on the development of IE. 

About the authors

A. V. Ponasenko

Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation

Author for correspondence.
Email: avapanass@mail.ru

PhD (Medicine), Head of the Laboratory for Genomic Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation

Russian Federation

A. G. Kutikhin

Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation

Email: fake@neicon.ru

Junior Researcher, Laboratory for Genomic Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation

Russian Federation

M. V. Khutornaya

Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation

Email: fake@neicon.ru

Junior Researcher, Laboratory for Genomic Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation

Russian Federation

A. E. Yuzhalin

Oxford Institute for Radiation Oncology, Oxford, UK

Email: fake@neicon.ru

PhD Candidate, Department of Oncology, CRUK and MRC Oxford Institute for Radiation Oncology, Oxford,  Great Britain

United Kingdom

N. V. Rutkovskaya

Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation

Email: fake@neicon.ru

PhD (Medicine), Senior Researcher, Laboratory for Bioprosthetic Heart Valves, Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russian Federation

Russian Federation

A. S. Golovkin

Federal North-West Medical Research Centre, St. Petersburg, Russian Federation

Email: fake@neicon.ru

PhD, MD (Medicine), Senior Researcher, Institute of Molecular Biology and Genetics, Federal Almazov North-West Medical Research Centre, St. Petersburg, Russian Federation

Russian Federation

References

  1. Тюрин В.П. Инфекционные эндокардиты: руководство. М.: ГОЭТАР-Медиа, 2012 368 с. [Tyurin V.P. Infektsionnye endokardity: rukovodstvo. [Infectious endocarditis: guidelines] Moscow: GEOTAR-Media, 2012. 368 p.]
  2. Baddley J.W., Benjamin D.K. Jr, Patel M., Miró J., Athan E., Barsic B., Bouza E., Clara L., Elliott T., Kanafani Z., Klein J., Lerakis S., Levine D., Spelman D., Rubinstein E., Tornos P., Morris A.J., Pappas P., Fowler V.G. Jr, Chu V.H., Cabell C.; International collaboration on endocarditis-prospective cohort study group (ICE-PCS). Candida infective endocarditis. Eur. J. Clin. Microbiol. Infect. Dis., 2008, vol. 27, no. 7, pp. 519–529. doi: 10.1007/s10096-008-0466-x
  3. Baddour L.M., Wilson W.R., Bayer A.S., Fowler V.G. Jr, Bolger A.F., Levison M.E., Ferrieri P., Gerber M.A., Tani L.Y., Gewitz M.H., Tong D.C., Steckelberg J.M., Baltimore R.S., Shulman S.T., Burns J.C., Falace D.A., Newburger J.W., Pallasch T.J., Takahashi M., Taubert K.A. Infective endocarditis. Diagnosis, antimicrobial therapy, and management of complications. Circulation, 2005, no. 111, рр. 394–434. doi: 10.1161/circulationaha.105.165564
  4. Chen Q., Zhou H., Wu S., Wang H., Lv C., Cheng B., Xie G., Fang X. Lack of association between TREM-1 gene polymorphisms and severe sepsis in a chinese han population. Hum. Immunol., 2008, vol. 69, no. 3, pp. 220–226. doi: 10.1016/j.humimm.2008.01.013
  5. Chu V.H., Cabell C.H., Benjamin D.K. Jr, Kuniholm E.F., Fowler V.G. Jr, Engemann J., Sexton D.J., Corey G.R., Wang A. Early predictors of in-hospital death in infective endocarditis. Circulation, 2004, vol. 109, no. 14, pp. 1745–1749. doi: 10.1161/01.CIR.0000124719.61827.7F
  6. Dower K., Ellis D.K., Saraf K., Jelinsky S.A., Lin L.L. Innate immune responses to TREM-1 activation: overlap, divergence, and positive and negative cross-talk with bacterial lipopolysaccharide. J. Immunol., 2008, vol. 180, no. 5, pp. 3520–3534. doi: 10.4049/jimmunol.180.5.3520
  7. Ford J.W., McVicar D.W. TREM and TREM-like receptors in inflammation and disease. Curr. Opin. Immunol., 2009, vol. 21, no. 1, pp. 38–46. doi: 10.1016/j.coi.2009.01.009
  8. Izumi K., Hisata Y., Hazama S. A rare case of infective endocarditis complicated by Trichosporonasahii fungemia treated by surgery. Ann. Thorac. Cardiovasc. Surg., 2009., vol. 15, no. 5, pp. 350–353
  9. Jung E.S., Kim S.W., Moon C.M., Shin D.J., Son N.H., Kim E.S., Lee H.J., Hong S.P., Kim T.I., Kim W.H., Cheon J.H. Relationships between genetic polymorphisms of triggering receptor expressed on myeloid cells-1 and inflammatory bowel diseases in the korean population. Life Sci., 2011, vol. 89, no. 9–10, pp. 289–294. doi: 10.1016/j.lfs.2011.06.018
  10. Karchmer A.W. Infective endocarditis. In: Harrison’s principles of internal medicine. Eds. Longo D.L., Fauci A.S., Kasper D.L., Hauser S.L., Jameson J.L., Loscalzo J.; 18th ed. New York: McGraw-Hill, 2012.
  11. Molloy E.J. Triggering receptor expressed on myeloid cells (TREM) family and the application of its antagonists. Recent Pat. Antiinfect. Drug. Discov., 2009, vol. 4, no. 1, pp. 51–56. doi: 10.2174/157489109787236292
  12. Nathan C., Ding A. TREM-1: a new regulator of innate immunity in sepsis syndrome. Nat. Med., 2001, vol. 7, no. 5, pp. 530–532. doi: 10.1038/87846
  13. Rivera-Chávez F.A., Huebinger R.M., Burris A., Liu M.M., Minei J.P., Hunt J.L., Arnoldo B.D., Barber R.C. A TREM 1 polymorphism A/T within the exon 2 is associated with pneumonia in burn-injured patients. ISRN Inflamm., 2013. doi: 10.1155/2013/431739
  14. San Román J.A., López J., Vilacosta I., Luaces M., Sarriá C., Revilla A., Ronderos R., Stoermann W., Gómez I., Fernández-Avilés F. Prognostic stratification of patients with left-sided endocarditis determined at admission. Am. J. Med., 2007, vol. 120, no. 4, pp. 1–7. doi: 10.1016/j.amjmed.2006.05.071
  15. Solé X., Guinó E., Valls J., Iniesta R., Moreno V. SNPStats: a web tool for the analysis of association studies. Bioinformatics, 2006, vol. 22, no. 15, pp. 1928–1929. doi: 10.1093/bioinformatics/btl268
  16. Su L., Liu C., Li C., Jiang Z., Xiao K., Zhang X., Li M., Yan P., Feng D., Xie L. Dynamic changes in serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and its gene polymorphisms are associated with sepsis prognosis. Inflammation, 2012, vol. 35, no. 6, pp. 1833–1843. doi: 10.1007/s10753-012-9504-z
  17. Wang A., Athan E., Pappas P.A., Fowler V.G. Jr, Olaison L., Paré C., Almirante B., Muñoz P., Rizzi M., Naber C., Logar M., Tattevin P., Iarussi D.L., Selton-Suty C., Jones S.B., Casabé J., Morris A., Corey G.R., Cabell C.H. International collaboration on endocarditis-prospective cohort study investigators. Contemporary clinical profile and outcome of prosthetic valve endocarditis. JAMA, 2007, vol. 297, no. 12, pp. 1354–1361. doi: 10.1001/jama.297.12.1354
  18. Yuzhalin A.E., Kutikhin A.G. Integrative systems of genomic risk markers for cancer and other diseases: future of predictive medicine. Cancer Manag. Res., 2012, vol. 4, pp. 131–135. doi: 10.2147/CMAR.S30855

Copyright (c) 2016 Ponasenko A.V., Kutikhin A.G., Khutornaya M.V., Yuzhalin A.E., Rutkovskaya N.V., Golovkin A.S.

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