THE CHARACTERIZATION OF PROAPOPTOTIC ACTIVITY OF LIPOPOLYSACCHARIDE IN ISOLATED SUBPOPULATIONS OF HUMAN T-LYMPHOCYTES

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  • Authors: Filatova E.N.1, Anisenkova E.V.2, Presnyakova N.B.2, Neumoina N.V.2, Sycheva T.D.3, Utkin O.V.3
  • Affiliations:
    1. Blokhina Research Institute of Epidemiology and Microbiology of Federal Service on Surveillance for Consumer Rights Protection and Human Welfare, Nizhny Novgorod, Russian Federation 603950, Russian Federation, Nizhni Novgorod, Malaya Yamskaya str., 71, Nizhny Novgorod State Medical Academy. Phone: +7 (831) 469-79-46, +7 (906) 368-37-22. Fax: +7 (831) 469-79-20.
    2. Blokhina Research Institute of Epidemiology and Microbiology of Federal Service on Surveillance for Consumer Rights Protection and Human Welfare, Nizhny Novgorod, Russian Federation
    3. Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russian Federation
  • Issue: Vol 4, No 4 (2014)
  • Pages: 347-352
  • Section: ORIGINAL ARTICLES
  • URL: https://iimmun.ru/iimm/article/view/245
  • DOI: https://doi.org/10.15789/2220-7619-2014-4-347-352

Cite item

Abstract

Lipopolysaccharide (LPS) is used as activator and inductor of immune cells apoptosis in case of infectious processes modeling. It is not clear if LPS is direct inductor of apoptosis in human T-cells. The subpopulations of effector and naive CD4+ T-helper and CD8+ cytotoxic T lymphocytes of human peripheric blood were isolated and cultivated in presence of LPS. It has been shown that LPS was inductor of apoptosis in studying T-cells populations.

About the authors

E. N. Filatova

Blokhina Research Institute of Epidemiology and Microbiology of Federal Service on Surveillance for Consumer Rights Protection and Human Welfare, Nizhny Novgorod, Russian Federation 603950, Russian Federation, Nizhni Novgorod, Malaya Yamskaya str., 71, Nizhny Novgorod State Medical Academy. Phone: +7 (831) 469-79-46, +7 (906) 368-37-22. Fax: +7 (831) 469-79-20.

Author for correspondence.
Email: el.filatova83@gmail.com

PhD (Biology), Leading Researcher, Laboratory of Molecular Biology and Biotechnology of Blokhina Research Institute of Epidemiology and Microbiology of Federal Service on Surveillance for Consumer Rights Protection and Human Welfare, Nizhny Novgorod, Russian Federation

Russian Federation

E. V. Anisenkova

Blokhina Research Institute of Epidemiology and Microbiology of Federal Service on Surveillance for Consumer Rights Protection
and Human Welfare, Nizhny Novgorod, Russian Federation

Email: fake@neicon.ru

Junior Researcher Laboratory of Molecular Biology and Biotechnology of Blokhina Research Institute of Epidemiology and Microbiology of Federal Service on Surveillance for Consumer Rights Protection and Human Welfare, Nizhny Novgorod, Russian Federation

Russian Federation

N. B. Presnyakova

Blokhina Research Institute of Epidemiology and Microbiology of Federal Service on Surveillance for Consumer Rights Protection
and Human Welfare, Nizhny Novgorod, Russian Federation

Email: fake@neicon.ru

Researcher Scientist Laboratory of Molecular Biology and Biotechnology of Blokhina Research Institute of Epidemiology and Microbiology of Federal Service on Surveillance for Consumer Rights Protection and Human Welfare, Nizhny Novgorod, Russian Federation

Russian Federation

N. V. Neumoina

Blokhina Research Institute of Epidemiology and Microbiology of Federal Service on Surveillance for Consumer Rights Protection
and Human Welfare, Nizhny Novgorod, Russian Federation

Email: fake@neicon.ru

PhD (Medicine), Medical Director, Clinic of Inflectious Deseases of Blokhina Research Institute of Epidemiology and Microbiology of Federal Service on Surveillance for Consumer Rights Protection and Human Welfare, Nizhny Novgorod, Russian Federation

Russian Federation

T. D. Sycheva

Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russian Federation

Email: fake@neicon.ru

Resident Physician, Department of Children Deseases of Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russian Federation

Russian Federation

O. V. Utkin

Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russian Federation

Email: fake@neicon.ru

PhD (Biology), Head of Laboratory of Molecular Biology
and Biotechnology of Blokhina Research Institute of Epidemiology and Microbiology of Federal Service on Surveillance for Consumer Rights Protection and Human Welfare, Assistant Professor of the Department of Microbiology and Immunology of Nizhny Novgorod State Medical Academy, Nizhny Novgorod, Russian Federation

Russian Federation

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Copyright (c) 2015 Filatova E.N., Anisenkova E.V., Presnyakova N.B., Neumoina N.V., Sycheva T.D., Utkin O.V.

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