RUBELLA VIRUS AND ITS TERATOGENIC ACTION. PATHOGENESIS, CLINICAL COURSE, DIAGNOSTICS AND PREVENTION OF CONGENITAL RUBELLA SYNDROME. ARTICLE 1. RUBELLA VIRUS: MOLECULAR–BIOLOGICAL CHARACTERISTICS

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Abstract. This review summarizes data about rubella virus and its teratogenic action, congenital rubella syndrome (CRS), modern methods of diagnostics and prevention of infection. The current article provide information concerning modern knowledge about structural and functional organization of Rubella virus (genius Rubivirus, family Togaviridae), stages of viral reproduction.

About the authors

A. J. Antipova

ФГУН «Санкт-Петербургский научно-исследовательский институт эпидемиологии и микробиологии имени Пастера» Роспотребнадзора, Санкт-Петербург

Author for correspondence.
Email: anti130403@mail.ru

младший научный сотрудник лаборатории детских вирусных инфекций

197101, Санкт-Петербург, ул. Мира, 14

Russian Federation

References

  1. Анджапаридзе О.Г., Червонский Г.И. Краснуха. — Москва, 1975. — 102 с.
  2. Вирусология: пер. с англ. / Под ред. Б. Филда, Д. Найпа. — М.: Мир, 1989. — Т. 2. — 494 c.
  3. Гайдамович С.Я., Логинова Н.В. Общая и частная вирусология / Под ред. В.М. Жданова, С.Я. Гайдамович — М.: Медицина, 1986. — Т. 2. — С. 49–95.
  4. Лаврентьева И.Н. Штамм «Орлов-Д» для получения живой аттенуированной вакцины против краснухи: Дис. ... д-ра мед. наук. — СПб., 2009. — 328 с.
  5. Львов Д.К., Урываев Л.В. Тогавирусы (Togaviridae) // Медицинская вирусология: Руководство; под ред. Д.К. Львова. — М.: ООО «Медицинс кое информационное агентство», 2008. — С. 217–224.
  6. Львов Д.К., Урываев Л.В. Краснуха // Медицинская вирусология: Руководство; под. ред. Д.К. Львова. — М: ООО «Медицинское информационное агенство», 2008. — 447–450 с.
  7. Семериков В.В., Лаврентьева И.Н., Таточенко В.К., Нисевич Л.Л., Фельдблюм И.В., Краснуха. — Пермь–СПб.–М.: ИПК «Звезда», 2002. — 175 с.
  8. Atreya C.D., Kulkarni S., Mohan K.V. Rubella virus P90 associated with cytokinesis regulatory protein Citron-k kinase and the viral infection and constitutive expression of 90 protein both induce cell cycle arrest following S phase in the cell culture // Arch. Virol. — 2004. — Vol. 149, N 4. — P. 779–789.
  9. Bardeletti G., Tektoff J., Gautheron D. Rubella Virus maturation and production in two host cell systems // Intervirology. — 1979. — Vol. 11, N 2. — P. 97–103.
  10. Baron M.D., Ebel T., Suomalainen M. Intracellular transport of rubella virus structural proteins expressed from cloned cDNA // J. Gen. Virol. — 1992. — Vol. 73. — P. 1073–1086.
  11. Baron M.D., Forsell K. Oligomerization of the structural proteins of rubella virus // Virology. — 1991. — Vol. 185. — P. 811–819.
  12. Beatch M.D., Hobman T.C. Rubella virus capsid associates with host cell protein p32 and localizes to mitochondria // J. Virol. — 2000. — Vol. 74, N 12. — P. 5569–5576.
  13. Chaye H.H., Mauracher C.A., Tingle A.J., Gillam S. Cellular and humoral immune responses to rubella virus structural proteins E1, E2 and C // J. Clin. Virol. —1992. — Vol. 30, N 9. — P. 2323–2329.
  14. Chaye H.H., Chong P., Tripet B., Brush B., Gillam S. Localization of the virus neutralizing and hemagglutinin epitopes of E1 glycoprotein of rubella virus // Virology. — 1992. — Vol. 189. — P. 483–492.
  15. Chen M.H. Rubella v 15. virus capcid protein modulates viral genome replication and virus infectivity // J. Virol. — 2004. — Vol. 78, N 8. — P. 4314–4322.
  16. Clark D.M., Loo T.W., McDonald H., Gillam S. Expression of rubella virus cDNA coding for the structural proteins // Gene. — 1988. — Vol. 65. — P. 23–30.
  17. Clarke D.M., Loo T.W., Hui I., Chong P., Gillam S. Nucleotide sequence and in vitro expression of rubella virus 24S subgenomic messenger RNA encoding the structural proteins E1, E2 and C // Nucleic Acids Research. — 1987. — Vol. 15, N 7. — P. 3041–3056.
  18. Claus C., Hofmann J., Überla K., Liebert U.G. Rubella virus pseudotypes and cell-cell fusion assay as tools for functional analysis of the rubella virus E2 and E1 envelope glycoproteins // J. Gen. Virol. — 2006. — Vol. 87. — P. 3029–3037.
  19. Corboba P., Grutadauria S., Cuffini C., Zapata M. Neutralizing monoclonal antibody to the E1 glycoprotein epitopeof rubella virus mediates virus arrest in vero cells // Viral. Immunol. — 2000. — Vol. 13, N 1. — P. 83–92.
  20. Dominguez C., Wang C.Y., Frey T.K. Sequence of the genome RNA of Rubella virus: evidence for genetic rearrangement during togavirus evolution // Virology. — 1990. — N 177. — P. 225–238.
  21. Duncan R., Esmaili A., Law L., Bertholet S., Hobman T., Nakhasi H. RUBV capsid protein induces apoptosis in transfected RK 13 cells // Virology. — 2000. — Vol. 275. — P. 20–29.
  22. Fontana J., López-Iglesias C., Tzenh W.-P., Frey T.K., Fernández J.J., Risco C. Three-dimensional structure of Rubella virus factories // Virology. — 2010. — Vol. 405, N 2. — P. 579–591.
  23. Forng R.J., Frey T.K. Identification of the Rubella virus nonstructural proteins // Virology. — 1995. — Vol. 206. — P. 843–853.
  24. Forng R.J., Atreya C.D. Mutations in the retinoblastoma protein-binding LXCXE motif of rubella virus putative replicase affect virus replication // J. Gen. Virol. — 1999. — Vol. 80. — P. 327–332.
  25. Frey T.K. Molecular biology of RUBV // Adv. Virus Res. — 1994. — Vol. 44. — P. 69–160.
  26. Frey T.K., Marr L.D. Sequence of the region coding for virions proteins C and E2 and the carboxy terminus of the nonstructural proteins of rubella virus: comparison with alphaviruses // Gene. — 1988. — Vol. 62. — P. 85–99.
  27. Fundamental virology // Chief Edition B.N. Fields, D.M. Knipe. — N.Y., 1989. — Vol. 2. — P. 344–346.
  28. Garbutt M., Law L.M., Chan H., Horban T.C. Role of rubella virus domains in assembly of virus-like particles // J. Virol. — 1999. — Vol. 73. — P. 3524–3533.
  29. Hobman T.C., Gillam S. In vitro and in vivo expression of rubella virus glycoprotein E2: the signal peptide is contained in the C-terminal region of capsid protein // Virology. — 1989. — Vol. 173. — P. 241–250.
  30. Horban T.C., Lundstrem M.L., Gillam S. Processing and intracellular transport of rubella virus structure protein in COS cells // Virology. — 1990. — Vol. 78. — P. 122–123.
  31. Kujala P. Intracellular distribution of rubella virus nonstructural protein 150 // J. Virol. — 1999. — Vol. 73, N 9. — P. 7805–7811.
  32. Lee J.Y., Marshall J.A., Bowden D.S. Localization of rubella virus core particles in vero cells // Virology. — 1999. — Vol. 265, N. 1. — Р. 110–119.
  33. Lee J.-Y., Bowden D.S. Rubella virus replication and links to teratogenicity // Clin. Microbiol. Rev. — 2000. — Vol. 13, N 4. — P. 571–587.
  34. Liang Y., Giilam S. Mutational analysis of the rubella virus nonstructural polyprotein and its cleavage products in virus replication and RNA synthesis // J. Virol. — 2000. — Vol. 74, N 11. — P. 5133–5141.
  35. Liang Y., Yao J., Gillam S. Rubella virus nonstructural protein protease domains involved in trans- and cyscleavage activities // J. Virol. — 2000. — Vol. 74, N 12. — P. 5412–5423.
  36. Liu Z.Y., Qui Z., Lim K.T., Chong P., Gillam S. Identification of domains in RUBV genomic RNA and capsid protein necessary for scecific interaction// J. Virol. — 1996. — Vol. 70. — P. 2184–2190.
  37. Marr L.D., Sanchez A., Frey T.K. Efficient in vitro translation and processing of rubella virus structural proteins in the presence of microsomes // Virology. — 1991. — Vol. 180. — P. 400–405.
  38. Marr L.D., Wang C.-J., Frey T.K. Expression of the rubella virus nonstructural protein ORF and demonstration of proteolytic processing // Virology. — 1994. — Vol. 198. — P. 586–592.
  39. Mastromarino P., Cioe L., Rieti S., Orsi N. Role of membrane phospholipids and glycolipids in the Vero cellssurface receptor for rubella virus // Med. Microbiol. Immunol. — 1990. — Vol. 179. — P. 105–114.
  40. Mauracher C.A., Gillam S., Shukin R., Tingle A.J. pH-dependent solubility shift of rubella virus capsid protein // Virology. — 1991. — Vol. 181. – P. 773–777.
  41. Menser M.A., Harley J.D., Hertzberg R., Dorman D.C., Murphy A.M. Persistence of virus in lens for three years after prenatal rubella // Lancet. — 1967. — Vol. 2, N 7512. — P. 387–388.
  42. Menser M.A., Forrest J.M. Rubella — high incidence of defect in children concidered normal at birth // JAMA. — 1974. — Vol. 1. — P. 123–126.
  43. Modin J.E., Brandling-Bennet A.D. Surveillance of Congenital Rubella Syndrom 1969–1973// Rev. Infect. Dis. — 1974. — Vol. 130. — P. 316–318.
  44. Nakhasi H.L., Zheng D., Hewlett K., Liu T. RUBV replication: effect on interferon and actinomycin D // Virus Res. — 1988. — Vol. 10. — P. 1–15.
  45. Oker-Blom C., Petterson R.F., Summers M.D. Baculovirus polyhedron promoter-directed expression of rubella virus envelope glycoproteins, E1 and E2, in Spodoptera frugiperda cells // Virology. — 1989. — Vol. 172, N 1. — P. 82–91.
  46. Oker-Blom C., Ulmanen I., Kääriäinen L., Pettersson R.F. Rubella virus 40S genome RNA specifies a 24S subgenomic mRNA that encodes for a precursor to structural proteins// J. Virol. — 1984. — Vol. 49. — P. 403–408.
  47. Oker-Blom C. The gene order for rubella virus structural proteins is NH2-C-E2-E1-COOH // J. Virol. — 1984. — Vol. 51. — P. 354–358.
  48. Petruzziello R., Orsi N., Macchia S., Rieti S.W., Frey T.K., Mastromarino P. Pathway of rubella virus infectious entry into Vero cells //J. Gen. Virol. — 1996. — Vol. 77. — P. 303–308.
  49. Peuvot J.A., Schanck L., Linds L., Brasseur R. Are the fussion processes involved in birth, life and death of he cell depending on tilted insertion of peptides into membranes? // J. Theoretic Biol. — 1999. — Vol. 198, N 2. — P. 173–181.
  50. Suomalainen M.H., Garoff H., Baron M.D. The E2 signal sequence of rubella virus remains part of the capsid protein and confers membrane association in vitro // J. Virol. — 1990. — Vol. 64. — P. 5500–5509.
  51. Terry G.M., Ho-Terry L., Rees K.R. Localization of rubella E1 epitopes // Arch. Virol. — 1988. — Vol. 98. — P. 189–197.
  52. Tzeng W.P., Frey T.K. C-E1 fusion protein synthesized by rubella virus DI RNAs maintained during serial passage // Virology. — 2006. — Vol. 356, N 1–2. — P. 198–207.
  53. Tzeng W.P., Frey T.K. Rubella virus capsid protein modulation of viral genomic and subgenomic RNA synthesis // Virology. — 2005. — Vol. 337, N 2. — P. 327–334.
  54. Vaheri A., Sedwick W.D., Plotkin S.A. Grown of the rubella virus in BHK 21 cells. 1. Virus production and infectivity assays // Prok. Soc. Exp. Biol. (N.Y.). — 1967. — Vol. 125. — P. 1086–1092.
  55. Webster W.S. Teratogen update: congenital rubella // Teratology. — 1998. — Vol. 58. — P. 13–23.
  56. WHO. Standardization of the nomenclature for genetic characteristics of wild-type rubella viruses // Wkly Epidemiol. Rec. — 2005. — Vol. 80. — P. 126–132.
  57. Yao J., Gillam S. A single-amino-acid substitution of a tyrosine residue in the rubella virus E1 cytoplasmic domain blocks virus release // J. Virol. — 2000. — Vol. 74, N 7. — Р. 3029–3036.
  58. Yao J., Gillam S. Mutational analysis, using a fulllength rubella virus CAN clone, of rubella virus E1 transmembrane and cytoplasmic domains required virus release // J. Virol. — 1999. — Vol. 73. — P. 4622–4630.
  59. Zheng D.-P., Katow Sh., Abernathy E.S., Song Ki-J., Xu W.-B., Yarulin V., Desjatskova R.G., Aboudy Y., Enders G., Croxson M. Global distribution of Rubella virus genotypes // Emerg. Infect. Dis. — 2003. — Vol. 9, N 12. — Р. 1523–1530.
  60. Zheng D.-P. Update of standard nomenclature for wild-type rubella viruses, 2007 // Wkly Epidemiol. Rec. — 2007. — Vol. 82, N 4. — P. 216–222.
  61. Zhou Y. Genomic analysis of diverse rubella virus genotypes / J. Gen. Virol. — 2007. — Vol. 88. — P. 932–941.
  62. http://www.ictvonline.org/virusTaxonomy.asp?version=2009

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