Clinical characteristics and Laboratory tests in full-term Neonates with Sepsis in Vietnam National Children's Hospital


Cite item

Abstract

ABSTRACT

Background: Sepsis is a life-threatening condition responding to an infectious agent causes damage to organs. Sepsis causes serious consequences in neonates due to high rates of mortality and sequelae and disability. Vietnam is a country in Southeast Asia, where the rate of infectious diseases is high in the world with high rates of infection, disability and mortality, as well as a middle-income country with a stratification health care system.

Aim: Evaluate the clinical and laboratory characteristics of patients at the Vietnam National Children’s Hospital.

Material and methods: A descriptive study was conducted on 85 full-term infants admitted to Vietnam National Children's Hospital in the period from 12/2019 to 4/2021.

Results: Common clinical symptoms in neonates with sepsis included poor feeding (89.4 %), respiratory failure (69.4 %), fever (51.8 %), tachycardia (52.8 %), shock (25 %). Anemic patients account for a high rate (72.9 %). Patients with increased white blood count accounted for 41.2 %, newborns with low white blood count accounted for 15.4 %. There were 49.6 % patients with low thrombocytopenia. Most patients had elevated CRP (88.3%). The mean value of nCD64 was 10167.1 ± 6136.9 molecules bound/cell, mHLA-DR was 9898.4 ± 14173.9 molecules bound/cell, Sepsis Index was 274.6 ± 287.5.

Conclusions: We recorded differences in clinical characteristics and Laboratory tests in full-term Neonates with Sepsis in National Children's Hospital. Of which, nCD64, mHLA-DR and Sepsis Index should be further investigated and referred as a prospective routine biomarker in diagnosis of neonatal sepsis.

 

About the authors

Thanh Binh Nguyen

Vietnam National Children's Hospital, Hanoi City, Vietnam
Hanoi Medical University, Hanoi City, Vietnam

Email: nguyenthingoctu.nhp@gmail.com

Ph.D., MD, Deputy head of hematology department at Vietnam National Children's Hospital

 

Viet Nam

Tu Thi Ngoc Nguyen

Vietnam National Children's Hospital, Hanoi City, Vietnam

Email: nguyenthingoctu.nhp@gmail.com
ORCID iD: 0000-0001-7317-8182

Ph.D, MD at General department at Vietnam National Children's Hospital

 

Viet Nam

Thi Ha Dang

Vietnam National Children's Hospital, Hanoi City, Vietnam

Email: nguyenthingoctu.nhp@gmail.com

MD at hematology department at Vietnam National Children's Hospital

 

Viet Nam

Bao Ngoc Nguyen

Vietnam National Children's Hospital, Hanoi City, Vietnam

Email: nguyenthingoctu.nhp@gmail.com

MD at hematology department at Vietnam National Children's Hospital

 

Viet Nam

Thi Mai Hong Truong

Prof.,Ph.D at Emergency Department at Vietnam National Children's Hospital

Email: nguyenthingoctu.nhp@gmail.com
Viet Nam

Thi Ha Le

Vietnam National Children's Hospital

Email: nguyenthingoctu.nhp@gmail.com

Manager of Neonatal center at Vietnam National Children's Hospital

 

Viet Nam

Ngoc Duy Le

Vietnam National Children's Hospital, Hanoi City, Vietnam

Author for correspondence.
Email: nguyenthingoctu.nhp@gmail.com

Head of Emergency Department at Vietnam National Children's Hospital

 

Viet Nam

Supplementary files

There are no supplementary files to display.


Copyright (c) Nguyen T.T.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 64788 от 02.02.2016.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies