Clinical characteristics and Laboratory tests in full-term Neonates with Sepsis in Vietnam National Children's Hospital
- Authors: Nguyen T.1, Nguyen T.T.2, Dang T.2, Nguyen B.2, Truong T.3, Le T.4, Le N.2
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Affiliations:
- Vietnam National Children's Hospital, Hanoi City, Vietnam Hanoi Medical University, Hanoi City, Vietnam
- Vietnam National Children's Hospital, Hanoi City, Vietnam
- Prof.,Ph.D at Emergency Department at Vietnam National Children's Hospital
- Vietnam National Children's Hospital
- Section: INFECTIOUS IMMUNOLOGY AT THE PRESENT STAGE
- URL: https://iimmun.ru/iimm/article/view/1861
- DOI: https://doi.org/10.15789/2220-7619-CCA-1861
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Abstract
ABSTRACT
Background: Sepsis is a life-threatening condition responding to an infectious agent causes damage to organs. Sepsis causes serious consequences in neonates due to high rates of mortality and sequelae and disability. Vietnam is a country in Southeast Asia, where the rate of infectious diseases is high in the world with high rates of infection, disability and mortality, as well as a middle-income country with a stratification health care system.
Aim: Evaluate the clinical and laboratory characteristics of patients at the Vietnam National Children’s Hospital.
Material and methods: A descriptive study was conducted on 85 full-term infants admitted to Vietnam National Children's Hospital in the period from 12/2019 to 4/2021.
Results: Common clinical symptoms in neonates with sepsis included poor feeding (89.4 %), respiratory failure (69.4 %), fever (51.8 %), tachycardia (52.8 %), shock (25 %). Anemic patients account for a high rate (72.9 %). Patients with increased white blood count accounted for 41.2 %, newborns with low white blood count accounted for 15.4 %. There were 49.6 % patients with low thrombocytopenia. Most patients had elevated CRP (88.3%). The mean value of nCD64 was 10167.1 ± 6136.9 molecules bound/cell, mHLA-DR was 9898.4 ± 14173.9 molecules bound/cell, Sepsis Index was 274.6 ± 287.5.
Conclusions: We recorded differences in clinical characteristics and Laboratory tests in full-term Neonates with Sepsis in National Children's Hospital. Of which, nCD64, mHLA-DR and Sepsis Index should be further investigated and referred as a prospective routine biomarker in diagnosis of neonatal sepsis.
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About the authors
Thanh Binh Nguyen
Vietnam National Children's Hospital, Hanoi City, VietnamHanoi Medical University, Hanoi City, Vietnam
Email: nguyenthingoctu.nhp@gmail.com
Ph.D., MD, Deputy head of hematology department at Vietnam National Children's Hospital
Viet Nam
Tu Thi Ngoc Nguyen
Vietnam National Children's Hospital, Hanoi City, Vietnam
Email: nguyenthingoctu.nhp@gmail.com
ORCID iD: 0000-0001-7317-8182
Ph.D, MD at General department at Vietnam National Children's Hospital
Viet Nam
Thi Ha Dang
Vietnam National Children's Hospital, Hanoi City, Vietnam
Email: nguyenthingoctu.nhp@gmail.com
MD at hematology department at Vietnam National Children's Hospital
Viet Nam
Bao Ngoc Nguyen
Vietnam National Children's Hospital, Hanoi City, Vietnam
Email: nguyenthingoctu.nhp@gmail.com
MD at hematology department at Vietnam National Children's Hospital
Viet Nam
Thi Mai Hong Truong
Prof.,Ph.D at Emergency Department at Vietnam National Children's Hospital
Email: nguyenthingoctu.nhp@gmail.com
Viet Nam
Thi Ha Le
Vietnam National Children's Hospital
Email: nguyenthingoctu.nhp@gmail.com
Manager of Neonatal center at Vietnam National Children's Hospital
Viet Nam
Ngoc Duy Le
Vietnam National Children's Hospital, Hanoi City, Vietnam
Author for correspondence.
Email: nguyenthingoctu.nhp@gmail.com
Head of Emergency Department at Vietnam National Children's Hospital
Viet Nam
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