Clinical characteristics and Laboratory tests in full-term Neonates with Sepsis in Vietnam National Children's Hospital

ABSTRACT

Background: Sepsis is a life-threatening condition responding to an infectious agent causes damage to organs. Sepsis causes serious consequences in neonates due to high rates of mortality and sequelae and disability. Vietnam is a country in Southeast Asia, where the rate of infectious diseases is high in the world with high rates of infection, disability and mortality, as well as a middle-income country with a stratification health care system.

Aim: Evaluate the clinical and laboratory characteristics of patients at the Vietnam National Children’s Hospital.

Material and methods: A descriptive study was conducted on 85 full-term infants admitted to Vietnam National Children's Hospital in the period from 12/2019 to 4/2021.

Results: Common clinical symptoms in neonates with sepsis included poor feeding (89.4 %), respiratory failure (69.4 %), fever (51.8 %), tachycardia (52.8 %), shock (25 %). Anemic patients account for a high rate (72.9 %). Patients with increased white blood count accounted for 41.2 %, newborns with low white blood count accounted for 15.4 %. There were 49.6 % patients with low thrombocytopenia. Most patients had elevated CRP (88.3%). The mean value of nCD64 was 10167.1 ± 6136.9 molecules bound/cell, mHLA-DR was 9898.4 ± 14173.9 molecules bound/cell, Sepsis Index was 274.6 ± 287.5.

Conclusions: We recorded differences in clinical characteristics and Laboratory tests in full-term Neonates with Sepsis in National Children's Hospital. Of which, nCD64, mHLA-DR and Sepsis Index should be further investigated and referred as a prospective routine biomarker in diagnosis of neonatal sepsis.