IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH MONOINFECTION BY HUMAN PAPILLOMAVIRUS AND IN PATIENTS CO-INFECTED BY PAPILLOMAVIRUS AND UROGENITAL PATHOGENS

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Abstract

Aim of this study was to investigate the characteristics of cellular and humoral immunity and functional activity of neutrophilic granulocytes in women with monoinfection by human papillomavirus and combination of human papillomavirus (HPVI) and urogenital pathogens (UGI). It was established that more serious disorders in the immune system in women were revealed in case of mixed HPVI and UGI in compare with case of monoinfection by human papillomavirus. Only in patients with combined HPVI and UGI the content of total lymphocytes, T-cells and cytotoxic T lymphocytes was reduced. In patients with combined HPVI and UGI the humoral immunity was characterised by increased concentration of IgM, its level of relative synthesis and content of circulating immune complexes. Independently of the infection type in women the reduction of CD4+ lymphocytes, NK-cells, increased number of γδТ-lymphocytes, as well as increase the functional activity of blood neutrophils have been detected. However, in case of combined HPVI and UGI an inhibitory effect on the reserve capacities of phagocytic cells was revealed.

About the authors

A. A. Savchenko

Institute of Medical Problems of the North, Siberian Division, Russian Academy of Medical Sciences, Krasnoyarsk

Author for correspondence.
Email: aasavchenko@yandex.ru

д.м.н., профессор, руководитель лаборатории молекулярно-клеточной физиологии и патологии
ФГБУ НИИ медицинских проблем Севера СО РАМН

Russian Federation

V. B. Tshai

Krasnoyarsk State Medical University named after Prof. V.F. Voyno-Yasenetsky of Ministry of Health of the Russian Federation, Krasnoyarsk

Email: fake@neicon.ru

д.м.н., профессор, зав. кафедрой перинатологии, акушерства и гинекологии лечебного факультета ГБОУ ВПО Красноярский государственный медицинский университет имени проф. В.Ф. Войно-Ясенецкого МЗ РФ

Russian Federation

K. Y. Kruglova

Institute of Medical Problems of the North, Siberian Division, Russian Academy of Medical Sciences, Krasnoyarsk

Krasnoyarsk State Medical University named after Prof. V.F. Voyno-Yasenetsky of Ministry of Health of the Russian Federation, Krasnoyarsk

Email: fake@neicon.ru

ассистент кафедры перинатологии, акушерства и гинекологии лечебного факультета ГБОУ ВПО Красноярский государственный медицинский университет имени проф. В.Ф. Войно-Ясенецкого МЗ РФ

Russian Federation

A. G. Borisov

Institute of Medical Problems of the North, Siberian Division, Russian Academy of Medical Sciences, Krasnoyarsk

Email: fake@neicon.ru

к.м.н., ведущий научный сотрудник лаборатории молекулярно-клеточной физиологии и патологии
ФГБУ НИИ медицинских проблем Севера СО РАМН

Russian Federation

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Copyright (c) 2014 Savchenko A.A., Tshai V.B., Kruglova K.Y., Borisov A.G.

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