HEMATOLOGICAL PARAMETERS IN HEPATOCELLULAR CARCINOMA & MICRORNA-223 GENE ASSOCIATED WITH HEPATITIS VIRUS IN LOCAL AREA



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Abstract

Background and Objective: Hepatocyte function may be altered by chronic HBV and HCV infections through similar mechanisms that influence the onset of hepatocellular cancer. This current work points to examine the function of microRNA-223 in Iraqi hepatocellular carcinoma (HCC) patients induced by hepatitis virus. microRNA-223 served as calibrator to explores its evaluate disease progression and diagnosis. Materials and method: Blood samples were then drawn from 20 people (males and females and different ages), some of them were latterly diagnosed with HCC. these blood samples were used later for molecular study to find target gene expression. Results: The importance of HCV, HB V, and liver cancer was examined in this study, along with the drop in research and studies conducted in Iraq. Those who got treatment had somewhat higher levels of microRNA-223 countenance, whereas those who were diagnosed early and did not get treatment had lower levels. MicroRNA-223 appearance stages were meaningfully lower in the first phase of hepatitis samples than in standard samples (P < 0.0001), which may indicate that microRNA-223 can be used as a biomarker to monitor conduct effectiveness. It is recommended that more research done in this area to help in diagnosis. Conclusion: MicroRNAs are an essential tool for early diagnosis and for monitoring the onset and progression of disease due to their great specificity and  reliability. all results hat HCC patients with HBV and HCV expressed muR-223 at lower levels than healthy controls. Some hematological and parameters differed significantly from those in the control group.

About the authors

Mohammed Salih Al-Janaby

University of Anbar, Al-Anbar, Iraq

Email: sci_mohammedsalih@uoanbar.edu.iq

Position: Academic teaching

academic title: Assistant Professor

academic degree : Ph.D.

Department of Biotechnology, College of Science, University of Anbar, Al-Anbar, Iraq;

Ирак

Rafat Hamdi Abdujaleel

University of Anbar, Al-Anbar, Iraq

Email: sc.r_alhadithi@uoanbar.edu.iq

Position: Academic teaching

academic title: Lecturer

academic degree : Ph.D.

Department of Biotechnology, College of Science, University of Anbar, Al-Anbar, Iraq;

Ирак

Mohammed Ayyed Najm

Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq

Email: dr.mohammed.ayyed@ibnsina.edu.iq

Position: Academic teaching

academic title: Assistant Professor

academic degree : Ph.D.

Department of Pharmacology, College of Medicine, Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq;

Ирак

Rana Talib Mohsen

University of Anbar, Al-Anbar, Iraq

Email: Rana2011@uoanbar.edu.iq

Position: Academic teaching

academic title: Assistant Professor

academic degree: Ph.D.

Department of Biotechnology, College of Science, University of Anbar, Al-Anbar, Iraq;

Ирак

Anmar Kamil Alalwani

University of Anbar, Al-Anbar, Iraq

Author for correspondence.
Email: anmar_kamil@uoanbar.edu.iq

Position: Academic teaching

academic title: Assistant Lecturer

academic degree master

Department of Biotechnology, College of Science, University of Anbar, Al-Anbar, Iraq;

Ирак

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