POLYMORPHISM OF DNA REPAIR SYSTEM PROTEIN GENES AND ITS ASSOCIATION WITH CHRONIC VIRAL HEPATITIS C



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Abstract

Abstract

Hepatitis C is an infectious disease that causes liver inflammation and often leads to a chronic process. The genes encoding proteins involved in DNA repair systems participate in developing immune responses and inflammation, making them promising candidates for studying genetic predisposition to a wide range of common diseases, including infections. However, this group of genes is rarely studied to assess their role in genetic susceptibility to infectious diseases.

In the present study, we investigated a role for polymorphisms in DNA repair system protein genes (ATM (rs189037 and rs1801516), NBN (rs709816 and rs1805800), MRE11 (rs473297), TP53BP1 (rs560191), MLH1 (rs1799977), PMS2 (rs1805321)) in the pathogenesis of chronic hepatitis C. As a result, associations were found both between some studied markers (rs1805321 in the PMS2 gene and rs1801516 in the ATM gene) and chronic hepatitis C as well as relations of various quantitative traits and the polymorphisms of these genes.

For example, variability in blood biochemical parameters (levels of cholesterol, glucose, iron, prothrombin index values, and thymol test results) was shown to depend on genotypes of two markers in the NBN gene (rs709816 and rs1805800). Clinical and morphological indicators are associated with variants in the NBN (rs1805800), MRE11 (rs473297), and PMS2 (rs1805321) genes. The absolute and relative levels of neutrophils are influenced by rs1805800 (NBN), rs473297 (MRE11), and rs1799977 (MLH1), whereas lymphocyte counts are affected by both markers in the NBN gene, rs473297 (MRE11), rs1799977 (MLH1), and rs1805321 (PMS2).

The lowest post-treatment IgG levels are observed in carriers of rarer genotypes in rs1805800 and rs709816 in NBN gene. Thus, our study demonstrates an impact of the studied genes on the pathogenesis of chronic hepatitis C, although the mechanism underlying such associations is not always clear. Nevertheless, our findings suggest about pleiotropic effects of DNA repair protein genes and their involvement in developing chronic hepatitis C.

About the authors

Nadezhda P. Babushkina

Research Institute of Medical Genetics, Tomsk National Research Medical Center

Email: nad.babushkina@medgenetics.ru
ORCID iD: 0000-0001-6133-8986
SPIN-code: 4639-1490
Scopus Author ID: 39961071300
ResearcherId: B-3106-2014

PhD in Biology, Senior Researcher, Population Genetics Laboratory, Research Institute of Medical Genetics, Tomsk National Research Medical Center

Россия

Valentina Evgenievna Shavrak

Research Institute of Medical Genetics, Tomsk National Research Medical Center

Email: laminatria21@gmail.com

Junior Researcher, Laboratory of Genomics of Orphan Diseases

Россия, Ushaiki River Embankment, 10; 634050, Tomsk, Russia

Шкштф Alexandrovna Goncharova

Research Institute of Medical Genetics, Tomsk National Research Medical Center

Email: irina.goncharova@medgenetics.ru
ORCID iD: 0000-0002-9527-7015
SPIN-code: 9399-9766
Scopus Author ID: 7003515492
ResearcherId: A-7918-2014

PhD in Biology, Researcher, Population Genetics Laboratory

Россия, Ushaiki River Embankment, 10; 634050, Tomsk, Russia

Ekaterina V. Beloborodova

Siberian State Medical University

Author for correspondence.
Email: beloborodova.ev@ssmu.ru
ORCID iD: 0000-0002-8776-5924
SPIN-code: 3905-2439
Scopus Author ID: 8914650400
ResearcherId: P-7915-2016

Professor, Department of Hospital Therapy with a course of rehabilitation, physiotherapy and sports medicine

Россия, 2 Moskovsky trakt, 634050, Tomsk

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