THE CHANGES OF OF CELLULAR IMMUNITY PARAMETERS IN PATIENTS WITH PREINVASIVE AND MICROINVASIVE CERVICAL CANCER BEFORE AND AFTER TREATMENT

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Abstract

Abstract. The comparative study of immunocompetent cells’ phenotype was performed in patients with the preinvasive and microinvasive cervical cancer before and after the treatment. Besides, the study of importance of selected cellular immunity indices as a predicitive factors of effective surgical treatment in a combination with immunotherapy (the study group) in comparison with a surgical treatment only (the control group) have been conducted. The true numerical normalization of subpopulation composition of peripheral blood lymphocyte has been determined including the expression level of suppressor lymphocytes molecular markers (FOXP3 и TGF-β1) and the expression level of CD95-marker in a study group in comparison with a control group. Moreover, true decrease of HPV (human papillomavirus) — positive patients (1.7%) and the absence of E7 oncoprotein in the study group have been discovered.

About the authors

P. I. Kovchur

Federal state-financed educational institution of high professional education «Petrozavodsk State University», Petrozavodsk

Author for correspondence.
Email: pkovchur@mail.ru

PhD (Medicine), Associate Professor, Department of Radiation Diagnosics, Therapy, Oncology, Tuberculosis and Urology

185910, Russian Federation, Petrozavodsk, Lenina pr., 33

 

Russian Federation

E. V. Bahidze

Federal state-financed institution «N.N. Petrov Research Institute of Oncology» of Russian Ministry of Health, St. Petersburg

Email: pkovchur@mail.ru
PhD, MD (Medicine), Leading Researcher, Department of Oncogynecology Russian Federation

A. V. Yastrebova

Federal state-financed educational institution of high professional education «Petrozavodsk State University», Petrozavodsk

Email: pkovchur@mail.ru
Assistant Professor, Department of Radiation Diagnosics, Therapy, Oncology, Tuberculosis and Urology Russian Federation

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